Diffusion-ordered spectroscopy (DOSY) NMR was successfully used to characterize amphiphilic block copolymers. A triblock copolymer prepared by ring-opening polymerisation of a lactide using poly(ethylene glycol) as the initiator. The DOSY experiment is revealed be useful analytical method prove formation According map, PLA and PEG blocks exhibited same diffusion coefficient 5.623 × 10−10 m2 s−1, consistent with an efficient lactide. determination critical micelle concentration (CMC)...

Amphiphilic and cationic PCL-based degradable polyester was synthesized by copper-catalyzed azide-alkyne cycloaddition (CuAAC).

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTSupramolecular Catalysis of Olefin [2 + 2] PhotodimerizationDario M. Bassani, Vincent Darcos, Sarah Mahony, and Jean-Pierre DesvergneView Author Information Laboratoire de Chimie Organique et Organométallique CNRS UMR 5802 Université Bordeaux 1 33405 Talence Cedex, France Cite this: J. Am. Chem. Soc. 2000, 122, 36, 8795–8796Publication Date (Web):August 24, 2000Publication History Received12 June 2000Published online24 August inissue...

Abstract The use of DMSO as solvent for transition metal mediated living radical polymerization was investigated using copper (I) bromide/N‐( n ‐propyl)‐2‐pyridyl‐methanimine catalyst system and ethyl‐2‐bromoisobutyrate initiator. best conditions in different methacrylates (MMA, BMA, DMAEMA, HEMA) were determined. In all cases, the measured number‐average molar mass product increased linearly with monomer conversion agreement theoretical M low polydispersity products (1.16 < PDI 1.4)...

A new functional lactone, α-iodo-ε-caprolactone (αIεCL), was synthesized from ε-caprolactone by anionic activation using a non-nucleophilic strong base (lithium diisopropylamide) followed an electrophilic substitution with iodine chloride. Ring-opening (co)polymerizations of the resulting monomer were carried out tin 2-ethylhexanoate as catalyst in toluene at 100 °C. Homopolymerization αIεCL achieved, and poly(αIεCL) fully characterized SEC, (1) H NMR elemental analysis. Random...

Well-defined graft copolymers were obtained using a copper-catalysed azide–alkyne Huisgen's cycloaddition click reaction from both biocompatible and non-toxic poly(ε-caprolactone) poly(2-methyl-2-oxazoline) homopolymers. Resulting amphiphilic proved to form micelles that could be used as potential drug carriers.

Silicate-based bioactive glass nano/microspheres hold significant promise for bone substitution by facilitating osteointegration through the release of biologically active ions and formation a biomimetic apatite layer. Cu-doping enhances properties such as pro-angiogenic antibacterial behavior. While sol-gel methods usually yield homogeneous spherical particles pure silica or binary glasses, synthesizing poorly aggregated Cu-doped ternary nano/microparticles without secondary CuO crystalline...

A first generation phosphorus-containing dendrimer with twelve terminal benzyl dithiobenzoate functions was designed and subsequently used as a multifunctional agent to derive hybrid star copolymers consisting of dendritic core surrounded by polystyrene branches reversible addition-fragmentation chain transfer (RAFT).

A new functional dilactone, 3-(2-propynyl)-1,4-dioxane-2,5-dione (4), was synthesized from ethyl glyoxalate and propargyl bromide via a 4-step reaction sequence. Ring-opening (co)polymerisation of the alkyne-functionalised monomer 4 with L-lactide carried out in dichloromethane at 30 °C using N,N-dimethylaminopyridine as catalyst benzyl alcohol an initiator. The resulting copolyesters were characterized by 1H NMR, size exclusion chromatography (SEC) MALDI-TOF spectroscopy. Azide...

A straightforward approach based on thiol–ene click chemistry was used to prepare novel functional polyesters containing amino groups. First, a series of well-defined alkene-functional poly(ε-caprolactone)s were prepared by ring-opening polymerization α-allyl-ε-caprolactone with ε-caprolactone in toluene and bulk using tin 2-ethylhexanoate as catalyst. These fully characterized 1H NMR, GPC, MALDI-TOF MS. The resulting random copolyesters obtained wide range molar masses from 3000 50 000 g...

Cancer vaccines are considered to be a promising tool for cancer immunotherapy. However, well-designed vaccine should combine tumor-associated antigen (TAA) with the most effective immunomodulatory agents and/or delivery system provoke intense immune responses against TAA. In present study, we introduced new approach by conjugating molecule LD-indolicidin hydrophilic chain end of polymeric emulsifier poly(ethylene glycol)-polylactide (PEG-PLA), allowing located close surface resulting...

ABSTRACT Novel thermo‐responsive poly( N ‐isopropylacrylamide)‐ block ‐poly( l ‐lactide)‐ ‐isopropylacylamide) (PNIPAAm‐ b ‐PLLA‐ ‐PNIPAAm) triblock copolymers were successfully prepared by atom transfer radical polymerization of NIPAAm with Br‐PLLA‐Br macroinitiator, using a CuCl/tris(2‐dimethylaminoethyl) amine (Me 6 TREN) complex as catalyst at 25 °C in , ‐dimethylformamide/water mixture. The molecular weight the ranges from 18,000 to 38,000 g mol −1 and dispersity 1.10 1.28. Micelles are...

Thermo-responsive P(NIPAAm-<italic>co</italic>-DMAAm)-<italic>b</italic>-PLLA-<italic>b</italic>-P(NIPAAm-<italic>co</italic>-DMAAm) triblock copolymers are synthesized <italic>via</italic> combination of ring-opening polymerization and atom transfer radical polymerization.

Abstract Novel 5‐ Z ‐amino‐δ‐valerolactone (5‐NHZ‐VL) was synthesized with an aim to prepare degradable polyesters and copolyesters having amino pendant groups. Following a straightforward efficient synthetic pathway, 5‐NHZ‐VL obtained in only two steps up 50% yield. The monomer fully characterized by 1 H NMR, 13 C ESI mass spectrometry, HPLC. Various conventional conditions were tested for this lactone ring‐opening polymerization led the novel corresponding poly(5‐NHZ‐VL) ( M n = 7000...

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying IL nature content leading to controlled release.

Hydrophobic macromolecular contrast agents (MMCAs) are highly desirable to provide safe and efficient magnetic resonance (MR) visibility implantable medical devices. In this study, we report on the synthesis evaluation of novel biodegradable poly(ε-caprolactone)-based MMCAs. Poly(α-propargyl-ε-caprolactone-co-ε-caprolactone)s containing 2, 5, 10 mol % propargyl groups have been prepared by ring-opening copolymerization ε-caprolactone corresponding propargylated lactone. parallel, a diazido...

Abstract In situ Fourier transform near infrared (FTNIR) spectroscopy was successfully used to monitor monomer conversion during copper mediated living radical polymerization with N ‐( n ‐propyl)‐2‐pyridylmethanimine as a ligand. The of vinyl protons in methacrylic monomers (methyl methacrylate, butyl and ‐hydroxysuccinimide methacrylate) methylene the polymer monitored an inert fiber‐optic probe. monitoring poly(butyl methacrylate‐ b ‐methyl ‐butyl triblock copolymer has also been reported...