A5059969550- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Lipid Membrane Structure and Behavior
- Nanoplatforms for cancer theranostics
- Mesoporous Materials and Catalysis
- Surfactants and Colloidal Systems
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Advanced Drug Delivery Systems
- Ocular and Laser Science Research
- Analytical Chemistry and Sensors
- Hydrogels: synthesis, properties, applications
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Chromatography
- Advanced Nanomaterials in Catalysis
- Diatoms and Algae Research
- biodegradable polymer synthesis and properties
- Extracellular vesicles in disease
- Retinal Diseases and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Silicon Nanostructures and Photoluminescence
- Ionic liquids properties and applications
- Aerogels and thermal insulation
Institut Charles Gerhardt Montpellier
2014-2024
École Nationale Supérieure de Chimie de Montpellier
2013-2024
Centre National de la Recherche Scientifique
2013-2024
Université de Montpellier
2013-2024
Institut de Chimie
2011-2022
Centre Occitanie-Montpellier
2016-2020
Institut des Biomolécules Max Mousseron
2017
Laboratoire des Matériaux Avancés
2017
Catalyse
2004-2017
École Normale Supérieure - PSL
2005-2015
Ibuprofen (an anti-inflammatory drug that is a crystalline solid at ambient temperature) has been encapsulated in MCM-41 silica matrices with different pore diameters (35 and 116 Å). Its behavior investigated by magic angle spinning (MAS) 1H, 13C, 29Si solid-state NMR spectroscopy low temperature. This study reveals an original physical state of the such materials. At temperature, ibuprofen not (crystalline or amorphous) extremely mobile inside pores, higher mobility largest pores (116 The...
Ionogels containing imidazolium ibuprofenate have been shown to be an efficient drug releasing system with kinetics controlled by the nature of silica wall.
Chitosan/silica hybrids were synthesized and shaped as microspheres, which may or not present a core/shell structure, depending on the experimental conditions. The core is constituted by homogeneous hybrid, while shell pure silica. amino groups of biopolymer are still accessible active sites for heterogeneous catalysis.
Abstract A thermoresponsive hydrogel, poly( N ‐isopropylacrylamide) (poly(NIPAM)), is synthesized in situ within an oxidized porous Si template, and the nanocomposite material characterized. Infiltration of hydrogel into interconnecting nanoscale pores SiO 2 host confirmed by scanning electron microscopy. The optical reflectivity spectrum hybrid displays Fabry–Pérot fringes characteristic thin film interference, enabling direct, real‐time observation volume phase transition confined...
Magnetic mesoporous silica nanoparticles (M-MSNs) represent promising targeting tools for theranostics. Engineering the interaction of (NPs) with biological systems requires an understanding protein corona formation around as this drives fate nanocarriers. We investigated behavior proteins in contact M-MSNs by high-throughput comparative proteomics, using human and bovine sera fluids, order to assess adsorption dynamics these media. Using system biology tools, especially protein–protein...
Interfacial tension, electrical conductivity, NMR self-diffusion and DLS experiments have been used to investigate the self-aggregation in water of ionic liquids associating an ibuprofenate anion 1-alkyl-3-methylimidazolium [CnMIm]+ (n = 4, 6, 8) cations. Despite short alkyl chain on imidazolium cations ≤ 8), these exhibit particularly low Critical Aggregation Concentrations (CAC), significantly lower than their parent chloride salts. This behaviour is attributed formation catanionic pairs...
Aggregates formed in an aqueous medium by three ionic liquids CnMImIbu made up of 1-alkyl-3-methyl-imidazolium cation (n = 4, 6, 8) and ibuprofenate anion are investigated. Dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), (1)H nuclear magnetic resonance measurements, atom-scale molecular dynamics simulations used to shed on the main interactions governing formation aggregates their composition. At high concentration, mixed micelles with a composition...
Checking the dosage! Carrying a drug adsorbed on mesoporous silica material may become standard to deliver drugs. But how can you be sure that is safely tucked inside channels (see graphic)? The authors tackle this tricky problem.
A new supra-organized hybrid material obtained in aqueous medium via anionic exchange of self-assembled unilamellar liposomes with the nitrate ions present interlayers layered double hydroxides (LDH) is fully characterized. This presents original properties linked to simultaneous presence a phospholipid bilayer derived from liposomes, still used as vectors for lipophilic drugs, and LDH, which protects brings about pH sensitivity. The rate controlled added amount liposomes. TGA, XRD, TEM...
Numerous bacterial toxins can cross biological membranes to reach the cytosol of mammalian cells, where they exert their cytotoxic effects. Our model toxin, adenylate cyclase (CyaA) from Bordetella pertussis, is able invade eukaryotic cells by translocating its catalytic domain directly across plasma membrane target cells. To characterize original translocation process, we designed an in vitro assay based on a biomimetic which tethered lipid bilayer (tBLM) assembled amine-gold surface...
A non-steroidal anti-inflammatory drug (ibuprofen) has been anchored inside the mesoporous channels of MCM-41-type silica and on a gel surface. The relevant anchoring procedure through an ester function investigated. It uses epoxide ring opening 3-glycidoxypropylsilane grafted surface by carboxylic-group-containing ibuprofen. control modification efficiency was achieved comparison spectroscopic data with those obtained using homogeneous counterparts. use nanostructured allowed accurate...