A5007667206- Immunotherapy and Immune Responses
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Dendrimers and Hyperbranched Polymers
- Cell Adhesion Molecules Research
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Solar-Powered Water Purification Methods
- Caveolin-1 and cellular processes
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
University of Twente
2021-2024
Abstract Alternatively-activated, M2-like tumor-associated macrophages (TAM) strongly contribute to tumor growth, invasiveness and metastasis. Technologies disable the pro-tumorigenic function of these TAMs are high interest immunotherapy research. Here we show that by designing engineered nanoliposomes bio-mimicking peroxidated phospholipids recognised internalised scavenger receptors, can be targeted. Incorporation possessing a terminal carboxylate group at sn-2 position into nanoliposome...
Abstract Since tumor stroma poses as a barrier to achieve efficacy of nanomedicines, it is essential evaluate nano-chemotherapeutics in stroma-mimicking 3D models that reliably predict their behavior regarding these hurdles limiting efficacy. In this study, we evaluated the effect paclitaxel-loaded polymeric micelles (PTX-PMCs) and nanoparticles (PTX-PNPs) stroma–mimicking vitro model. PTX-PMCs (77 nm) based on amphiphilic block copolymer mPEG-b-p(HPMAm-Bz) PTX-PNPs (159...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor type with low patient survival due to the efficacy of current treatment options. Cancer-associated fibroblasts (CAFs) in microenvironment (TME) create dense fibrotic environment around cells, preventing therapies from reaching their target. Novel 3D vitro models are needed that mimic this barrier for development biologically relevant environment. Here, novel PDAC microtissues (µtissues) consisting pancreatic cancer cell...
Although, extracellular vesicles (EVs) appear as future promising therapeutics, their in vivo instability after administration remains an important barrier to development. While many groups have evaluated EV surface modification strategies add a targeting group control biodistribution, far fewer focused on stabilization obtain "stealth" allogenic EVs. This aspect is fundamental prerequisite for development nano therapeutics. Here, we explored lipid anchorage the membrane of PEG alternative,...