A5030304038- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Alcoholism and Thiamine Deficiency
- Diabetes and associated disorders
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Metabolism and Genetic Disorders
- Eicosanoids and Hypertension Pharmacology
- Advanced Glycation End Products research
- Pharmacological Effects and Assays
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
- Natural Antidiabetic Agents Studies
- Environmental and Ecological Studies
- Lipid metabolism and biosynthesis
- Gut microbiota and health
- Microtubule and mitosis dynamics
- Carbohydrate Chemistry and Synthesis
- Meat and Animal Product Quality
The University of Queensland
2009-2024
Brisbane School of Theology
2018
Southend University Hospital NHS Foundation Trust
2008
University of Nebraska Medical Center
2001-2005
King's College London
2001-2005
Tampere University
1996-2005
Seinäjoki University of Applied Sciences
2005
Tampere University Hospital
2005
Southend Hospital
2004
Etelä-Pohjanmaan Sairaanhoitopiiri
2003
Malondialdehyde and acetaldehyde react together with proteins form hybrid protein conjugates designated as MAA adducts, which have been detected in livers of ethanol-fed animals. Our previous studies shown that adducts are comprised two distinct products. One adduct is composed molecules malondialdehyde one molecule was identified the 4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde derivative an amino group (MDHDC adduct). The other a 1:1 2-formyl-3-(alkylamino)butanal (FAAB In this study,...
We have developed a novel functional nucleic acid aptamer to amyloid-β peptide 1–40 (Aβ<sub>1–40</sub>) and investigated its potential detect Aβ fragments in neuropathologically confirmed Alzheimer brain hippocampus tissues samples.
Abstract. Several recent reports have shown that antibodies reactive with acetaldehyde (AcH)‐modified epitopes are present in alcoholics. However, similar also been found patients nonalcoholic liver disease and control subjects. In each of these studies total immunoglobulin binding to the AcH‐modified proteins was measured, no attempt being made identify classes involved. study we employed an enzyme‐linked immunosorbent assay (ELISA) assess involved this response, using plasma samples from...
Elevated concentrations of plasma tumour necrosis factor (TNF)‐α, interleukin (IL)‐1 and IL‐6 have been detected in patients with alcoholic hepatitis implicated the pathogenesis hepatocyte necrosis. The present study used a rat model to conduct detailed histological biochemical examination expression various pro‐inflammatory cytokines associated liver pathology ethanol‐potentiated lipopolysaccharide (LPS)‐induced injury. Male Wistar rats were pair‐fed either control or ethanol‐containing...
Journal Article ETHANOL INDUCES THE PRODUCTION OF ANTIBODIES TO ACETALDEHYDE-MODIFIED EPITOPES IN RATS Get access SIMON WORRALL, WORRALL * Alcohol Research Unit, Department of Biochemistry, University QueenslandSt. Lucia, Qld. 4067, Australia To whom all correpondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHN DE JERSEY, JERSEY BRIAN C. SHANLEY, SHANLEY PETER A. WILCE and Alcoholism, Volume 24, Issue 3, 1989, Pages 217–223,...
This article presents the proceedings of a symposium presented at ISBRA 12th World Congress on Biomedical Alcohol Research, held in Heidelberg/Mannheim, Germany, September 29 through October 2, 2004. The organizers were Simon Worrall and Victor Preedy, was chaired by Onni Niemelä Geoffrey Thiele. presentations scheduled for this (1) Adduct chemistry mechanisms adduct formation, Thomas L. Freeman; (2) Malondialdehyde‐acetaldehyde adducts: 2004 update, Thiele; (3) formation liver, Worrall; (4)...
Several studies have recently shown the presence of antibodies against acetaldehyde-modifications in sera alcoholic patients. To assess specificity this immune response, plasma immunoreactivity with proteins modified vitro by acetaldehyde was measured using an enzyme-linked immunosorbent assay 97 patients varying degrees liver disease, 35 non-alcoholic diseases and 33 control subjects who were social drinkers. All three groups showed some response acetaldehyde-modified epitopes. The highest...
Obesity has emerged as a major public health challenge in the 21st century, contributing to rising prevalence of metabolic syndrome (MetS), cluster interrelated risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and dyslipidaemia. In this review, we will explore important aspects regulation dynamics lipoprotein metabolism see how they underlie each these risks. Additionally, highlight role ferroptosis, an iron-dependent...
This article represents the proceedings of a workshop at 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Geoffrey M. Thiele and Simon Worrall. presentations (1) chemistry malondialdehyde‐acetaldehyde (MAA) adducts, by Dean J. Tuma; (2) formation clearance MAA adducts ethanol‐fed rats, Worrall; (3) Immune responses to may play role development alcoholic liver disease, Lynell W. Klassen; (4) Unique biological MAA‐modified proteins that and/or progression Thiele; (5) MAA‐adducted bovine...
To date, no study has investigated the effects of bupropion (BP) in renal-impaired humans. This aims to identify pharmacokinetics BP and metabolites haemodialysis patients who smoke, determine whether affects metabolite clearance, suggest dose haemodialysis. The two its major metabolites, hydroxybupropion (HB) threohydrobupropion (TB) were studied 8 smokers with ESRD receiving Following a single oral 150 mg hydrochloride sustained-release, blood samples taken over 7 days, which assayed using...
This article represents the proceedings of a symposium at 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Victor R. Preedy and Junko Adachi. presentations (1) Alcoholic myopathy: Past, present future, by Timothy J. Peters Preedy; (2) Protein adducts type I II fiber‐predominant muscles ethanol‐fed rat, Simon Worrall, Seppo Parkkila, Onni Niemela; (3) Hydroperoxides changes alcoholic myopathy, Adachi, Migiwa Asamo, Yasuhino Ueno; (4) A close association between testicular atrophy,...
Acetaldehyde, the main metabolite of ethanol, is a highly reactive species that reacts with macromolecules to produce unstable and stable adducts. Acetaldehyde‐modifled proteins are immunogenic have been detected in liver blood alcoholics. Furthermore, antibodies acetaldehyde‐modified plasma social drinkers However, class distribution immunoglobulins modified was different two groups, being predominantly immunoglobulin (Ig)M drinkers, but IgM IgA In this study, we demonstrate heavy (alcohol...
Background Chronic alcoholic myopathy is characterised by reduced muscle strength and structural changes including a decrease in the diameter of Type II (glycolytic, fast‐twitch, anaerobic) fibres. In contrast, I fibres (oxidative, slow‐twitch, aerobic) are relatively protected. It possible that adduct formation with reactive metabolites ethanol may be contributory process. Materials Methods We analysed skeletal muscles from rats fed nutritional‐complete liquid diets containing as 35% total...
Previous studies have shown that acetaldehyde (AcH)-modified proteins are formed in the liver and blood of rats fed ethanol-containing diets. In this study we report application ELISA techniques to subcellular distribution turnover AcH-modified ethanol-fed control rats. Modified were found mitochondrial, crude membrane cytosolic fractions, as well plasma from No adducts detected by our assay haemolysates same animals. The rate decline after cessation ethanol feeding was also examined. with a...