A5029103272- Enzyme Structure and Function
- Erythrocyte Function and Pathophysiology
- Contact Dermatitis and Allergies
- Metal complexes synthesis and properties
- Protein purification and stability
- Protein Structure and Dynamics
- Parasitic Infections and Diagnostics
- Toxin Mechanisms and Immunotoxins
- Porphyrin Metabolism and Disorders
- Glycosylation and Glycoproteins Research
- Food Allergy and Anaphylaxis Research
- Transgenic Plants and Applications
- Biomedical Research and Pathophysiology
- Coccidia and coccidiosis research
- Reproductive tract infections research
- S100 Proteins and Annexins
- Cancer-related gene regulation
- Connexins and lens biology
- Calpain Protease Function and Regulation
- Cell death mechanisms and regulation
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Venomous Animal Envenomation and Studies
- Regulation of Appetite and Obesity
- Cancer therapeutics and mechanisms
Instituto Politécnico Nacional
2013-2024
The dimeric nature of triosephosphate isomerases (TIMs) is maintained by an extensive surface area interface more than 1600 Å2. TIMs from Trichomonas vaginalis (TvTIM) are held in their state two mechanisms: a ball and socket interaction residue 45 one subunit that fits into the hydrophobic pocket complementary swapping loop 3 between subunits. TvTIMs differ other unfolding energetics. In energy necessary to unfold monomer greater dissociate dimer. Herein we found character I45 controls...
Enolase, which catalyses the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate, is an important enzyme in classic glycolysis pathway cells. Enolase highly conserved organisms from bacteria humans, indicating its importance Thus, enolase a good target for developing new drugs. In last decade, functions this have been found. Helicobacter pylori common human pathogen that causes gastric diseases and even cancer. study, sequence H. (HpEno) was analysed; conservation (at least partial)...
In plants, the ancestral cyanobacterial triosephosphate isomerase (TPI) was replaced by a duplicated version of cytosolic TPI. This isoform acquired transit peptide for chloroplast localization and functions in Calvin-Benson cycle. To gain insight into reasons this gene replacement we characterized TPI from photosynthetic bacteria Synechocystis (SyTPI). SyTPI presents typical enzyme kinetics profiles assembles as homodimer composed two subunits that arrange (-)8 fold. We found oxidizing...
The leptin-leptin receptor complex is at the very core of energy homeostasis and immune system regulation, among many other functions. In this work, we built homology models leptin binding domain (LBD) from humans mice. Docking analyses were used to obtain coordinates native leptin-LBD complexes a mixed heterodimer formed by human mouse LBD. Molecular dynamics (MD) simulations performed using all (monomers heterodimers) as initial GROMACS program. overall structural dynamical behaviors are...
Abstract The high expression of anti‐apoptotic Bcl‐2 protein in cancer cells can confer resistance to apoptosis, allowing evade cell death signals and continue proliferating. Therefore, has become a crucial target for therapy. In this work, we looked new drugs targeting that induce apoptosis improve treatment effectiveness like chemotherapy. silico approaches, such as molecular docking, were used identify potential by screening the Enamine collection (HLL‐460) against two conformations...
Abstract Voltage-gated sodium channels (Na V ) are pivotal proteins responsible for initiating and transmitting action potentials. Emerging evidence suggests that proteolytic cleavage of by calpains is in diverse physiological scenarios, including ischemia, brain injury, neuropathic pain associated with diabetes. Despite this significance, the precise mechanism which recognize channels, especially given multiple calpain isoforms expressed neurons, remains elusive. In work, we show...
Introducción: El factor de transferencia (FT) es el extracto dializable leucocitos con propiedades inmunidad celular. Su uso se ha extendido en tratamiento una amplia gama padecimientos inmunológicos, infecciosos y como coadyuvante oncológicos. A pesar ello, no conocen completamente aspectos importantes su perfil proteico, concentraciones componentes mecanismos acción.Objetivos: Analizar los perfiles proteicos diferentes factores comercializados México.Métodos: Se obtuvieron analizaron 6 FT...
Human alpha-L-iduronidase (IDUA) is a 653 amino acid protein involved in the sequential degradation of glycos-amino-glycans (GAG), heparan sulfate (HS), and dermatan (DS). Some variants IDUA gene produce deficient enzyme that causes un-degraded DS HS to accumulate multiple tissues, leading an organ dysfunction known as muco-poly-saccharidosis type I (MPS I). Molecular catalytic activity assays new or rare do not predict phenotype patient will develop. Therefore, it interest describe...