A5010927128- Renin-Angiotensin System Studies
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- GDF15 and Related Biomarkers
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Cardiac Fibrosis and Remodeling
- Cardiac Health and Mental Health
- Birth, Development, and Health
- Potassium and Related Disorders
- Cardiovascular and exercise physiology
- Genetic Associations and Epidemiology
- Eicosanoids and Hypertension Pharmacology
- Nutrition, Genetics, and Disease
- Nuclear Receptors and Signaling
- Atrial Fibrillation Management and Outcomes
- Membrane-based Ion Separation Techniques
- Cardiovascular Health and Disease Prevention
- Cardiovascular Effects of Exercise
Sapienza University of Rome
2013-2024
Istituto Neurologico Mediterraneo
2012-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2024
Azienda Ospedaliera Sant'Andrea
2007-2024
Istituti di Ricovero e Cura a Carattere Scientifico
1994-2024
CTO Andrea Alesini
2020
Centro Cardiologico Monzino
2013
University of Milan
2013
William Harvey Research Institute
2013
Rutgers New Jersey Medical School
2013
Background and Purpose— A precise definition of genetic factors responsible for common forms stroke is still lacking. The purpose the present study was to investigate contributory role genes encoding atrial natriuretic peptide ( ANP ) type receptor NPRA in humans’ susceptibility develop ischemic stroke. Methods— Allele genotype frequencies were characterized an Italian case-control with patients affected by vascular disease or risk factors. Subjects recruited from island Sardinia (206 cases,...
To investigate whether the response of salt-regulating hormones to volume expansion is impaired in obese subjects, we assessed effects saline load (0.25 mL/kg.min.120 min) 9 young, healthy, normotensive subjects (body mass index, > 30 kg/m2) and 10 lean control < 25 matched for age, gender, height, mean blood pressure. Hematocrit, plasma renin activity (PRA), aldosterone (PA), atrial natriuretic factor (ANF), urinary sodium excretion (UNaV) were evaluated. Saline increased ANF levels...
Background:Previous studies have shown that metabolic syndrome (MS) is associated with an increased susceptibility to develop cardiovascular damage (CD). Experimental evidence indicates inflammation and fibrosis could play a critical role in the development of CD hypertension. This issue has not been clarified yet patients MS. The aim our study was investigate relationship between markers hypertensive without
The stroke-prone spontaneously hypertensive rat (SHRsp) represents an animal model of increased susceptibility to high-salt diet-induced cerebral and renal vascular injuries. High blood pressure genetic factors are viewed as major contributing factors. In high-salt-loaded SHRsp stroke-resistant SHR animals, we determined levels, degree kidney lesions, uncoupling protein 2 (UCP2) gene expression levels along with rattus norvegicus (rno)-microRNA (miR) 24 34a expression, nuclear factor-κB...
Background —Recent evidence from an animal model of stroke, the stroke-prone spontaneously hypertensive rat, implicated gene encoding atrial natriuretic peptide ( ANP ) as a possible candidate contributing to likelihood experiencing stroke. The purpose present study was investigate role in pathogenesis cerebrovascular accidents humans. Methods and Results —We investigated 2 previously known markers at , G1837A T2238C for their association with occurrence This largest matched case-controlled...
While hypertension is a major risk factor for stroke, it not its sole determinant. Despite similar blood pressures, spontaneously hypertensive rats (SHR) do share the predisposition to cerebrovascular disease typical of stroke-prone (SHRSP). We investigated vascular function in male SHR and SHRSP as well SHRSP/SHR-F2 hybrid animals. Animals were maintained on appropriate dietary regimen necessary manifestation stroke. Among animals, group stroke-resistant selected. Blood pressure was all...
To investigate whether the response of atrial natriuretic factor (ANF) to volume expansion is impaired in early stages dilated cardiomyopathy, effects saline load (SL; 0.25 ml/kg.min for 120 min) were assessed 12 patients with cardiomyopathy and asymptomatic mildly symptomatic heart failure (HF) nine normal subjects (N). SL increased plasma ANF levels N (from 14.3 +/- 2 19.5 3 26 4 pg/ml, at 60 min, respectively, P less than 0.001), but not HF 42.9 9 45.9 43.9 8 pg/ml). Left ventricular...
Reversible Cryoactivationof Human Prorenin hamster ovary cells transfected with a vector containing cDNA for preprorenin and was purified by affinity chromatography (26).It gift from the Upjohn Company.Prorenin concentration determined standardization against human renal renin after trypsin activation (described below); 1 Goldblatt unit (GU) of generates 120 pg angiotensin I/h substrate (angiotensinogen) at K,,,.A stock solution (determined to have prorenin 115 GU/ml) in 50 mM Tris-C1, pH...
Objective The platelet GPIIIa plays a pivotal role in aggregation. Previous studies showed an association between the PlA1/A2 polymorphism and coronary thrombosis, while there is only contrasting evidence about its stroke. We explored possibility that this represents risk factor for stroke hypertensive patients. Methods studied two populations. In loco, we genotyped 140 control individuals 28 patients with ischemic Furthermore, performed analysis of previously published data 451 Sardinian...