A5085622092- Connective Tissue Growth Factor Research
- Pancreatitis Pathology and Treatment
- Noise Effects and Management
- Epigenetics and DNA Methylation
- Hearing Loss and Rehabilitation
- Connective tissue disorders research
- Parvovirus B19 Infection Studies
- Maternal and Perinatal Health Interventions
- Congenital Anomalies and Fetal Surgery
- Acoustic Wave Phenomena Research
- Prenatal Screening and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Digestive system and related health
- Fibroblast Growth Factor Research
- Reproductive Health and Contraception
- Vehicle Noise and Vibration Control
- Cancer Cells and Metastasis
- Diet, Metabolism, and Disease
- Viral Infectious Diseases and Gene Expression in Insects
- Maternal Mental Health During Pregnancy and Postpartum
- Genetics, Bioinformatics, and Biomedical Research
- Cancer-related gene regulation
University of California, Los Angeles
2012-2022
UCLA Jonsson Comprehensive Cancer Center
2016
Broad Center
2016
CCN2/Connective Tissue Growth Factor (CTGF) is a matricellular protein that regulates cell adhesion, migration, and survival. CCN2 best known for its ability to promote fibrosis by mediating the of transforming growth factor β (TGFβ) induce excess extracellular matrix production. In addition role in pathological processes, required chondrogenesis. also highly expressed during development endothelial cells, suggesting angiogenesis. The potential angiogenesis unclear, however, as both pro-...
The objective of the study was to investigate if hypoxia-inducible factor (HIF)-1α and connective tissue growth (CCN2) form a regulatory network in hypoxic nucleus pulposus (NP) cells. A decrease CCN2 expression proximal promoter activity observed NP cells after culture. Analysis both human mouse promoters using JASPAR core database revealed presence putative hypoxia response elements. Transfection experiments showed that activities decreases HIF-1α-dependent fashion. Interestingly, deletion...
CCN2 (connective tissue growth factor (CTGF/CCN2)) is a matricellular protein that utilizes integrins to regulate cell proliferation, migration and survival. The loss of leads perinatal lethality resulting from severe chondrodysplasia. Upon closer inspection Ccn2 mutant mice, we observed defects in extracellular matrix (ECM) organization hypothesized the chondrodysplasia caused by might be associated with defective chondrocyte plate chondrocytes exhibited enlarged endoplasmic reticula (ER),...
Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1-null mutation are resistant hypercholesterolemia compared wild-type C57BL/6J through enhanced cholesterol conversion acids. To further characterize role metabolism, we generated Diet1−/− on genetic background. had elevated levels, reduced Fgf15 expression, and increased gastrointestinal motility luminal water...
Background: Noise sensitivity moderates the association between environmental noise exposure and annoyance health outcomes. Methods: In normally hearing adults, we measured in three ways: using questionnaire, a 3-point self-rating, loudness discomfort level (LDL; mean reported for tone bursts). We then presented recordings of 15-second 80 dBLAeq aeroplane overflight participants rated they experienced. Results: The measures were not well correlated with each other, only overall LDL was...
Abstract Purpose To report the rate of fetal anomalies detected on anatomy ultrasound in pregnant patients who underwent IVF with preimplantation genetic testing for aneuploidy (PGT-A) compared to conceived following unscreened embryos and age-matched natural conceptions. Methods Retrospective cohort study at a single maternal-fetal medicine practice. Patients singleton pregnancies had mid-trimester between January 2017 December 2018 were screened inclusion. A total 712 after or without...
Abstract Objective To assess patient and provider perspectives on the acceptability of reproductive goals assessment in public mental health clinics inform potential tailoring for these settings. Data Sources Study Setting Primary qualitative data from patients providers at four an urban system serving individuals with chronic illness (collected November 2020–October 2021). Design This was exploratory study (English‐speaking women age, primarily Black or Latina) (psychiatrists,...
It is not clear how the distribution of noise sound-energy over time influences people. We compared perceived loudness, annoyance and ability to perform a cognitive task in people exposed recordings aircraft noise, presented either as single 15-second overflight at 80 dB LeqA15seconds or four overflights 60 LeqA15seconds. Levels were chosen on basis that an increase 10 doubles thus stimuli might be expected seem loud stimulus dB. Participants performed engaging mental arithmetic during half...