Angiogenic magnetic hydrogels are attractive for tissue engineering applications because their integrated properties can improve angiogenesis while providing guidance and stimulation healing. In this study, we synthesized nanoparticles (MNPs) with curcumin as an angiogenic agent, referred to CMNPs, via a one-pot coprecipitation method. We dispersed CMNPs in hyaluronic acid (HyA) create hydrogels. showed slightly reduced average diameter compared that of MNPs content 11.91%. exhibited...

Demineralized bone matrix (DBM) has been widely used as an allogeneic alternative to autologous graft for repair. However, more extensive use of DBM is limited due its particulate nature after demineralization and rapid particle dispersion following irrigation, resulting in unpredictable osteoinductivity. Here, a new design injectable hydrogel carriers that combine self-healing ability osteogenic properties based on the self-assembly guanidinylated hyaluronic acid silica-rich nanoclays...

Piezoelectric materials are promising for biomedical applications because they can provide mechanical or electrical stimulations via converse direct piezoelectric effects. The have been proven to be beneficial cell proliferation and tissue regeneration. Recent reports showed that doping different contents of reduced graphene oxide (rGO) polyaniline (PANi) into biodegradable polyhydroxybutyrate (PHB) enhanced their response, showing potential applications. In this study, we aim determine the...

Abstract Exosomes derived from mesenchymal stem cells are an active area of research due to their therapeutic potential in treating osteoporosis. To further harness performance modulating bone resorption, equipped exosomes with osteoclast‐targeting moieties on surface as well chemokine receptor antagonists blocking osteoclast recruitment. Phosphatidylserine (PS), a membrane lipid exerting immunosuppressive and phagocytic signals, is incorporated the exosome mimetics (EMs) achieve marked...

It is highly desirable for bone tissue engineering scaffolds to have significant osteogenic properties and capability improve cell growth thus enhance regeneration. In this study, a poly(l-lactic acid) (PLLA) nanofiber scaffold-immobilized peptide (OGP) was prepared via polydopamine (PDA) coating. X-ray photoelectron spectroscopy (XPS), contact angle measurement, scanning electron microscopy (SEM) were used determine the OGP immobilization, hydrophilicity surface roughness of samples. The...

Polymer/ceramic nanocomposites integrated the advantages of both polymers and ceramics for a wide range biomedical applications, such as bone tissue repair. Here, we reported triphasic poly(lactic-co-glycolic acid) (PLGA, LA/GA = 90:10) with improved dispersion hydroxyapatite (HA) magnesium oxide (MgO) nanoparticles using process that benefits ultrasonic energy dual asymmetric centrifugal mixing. We characterized microstructure composition evaluated effects HA/MgO ratios on degradation...

Magnesium–zinc–calcium (Mg–Zn–Ca) alloys have attracted increasing attention for biomedical implant applications, especially bone repair, because of their biocompatibility, biodegradability, and similar mechanical properties to human bone. The objectives this study were characterize Mg–2 wt % Zn–0.5 Ca (named ZC21) alloy pins microstructurally mechanically, determine degradation interactions with host cells pathogenic bacteria in vitro vivo comparison the previously studied Mg–4 Zn–1...

This article reports tunable crosslinking, reversible phase transition, and three-dimensional printing (3DP) of hyaluronic acid (HyA) hydrogels via dynamic coordination Fe3+ ions with their innate carboxyl groups for the first time. The concentrations H+ reaction time determine ratios mono-, bi-, tridentate coordination, leading to low-to-high crosslinking densities solid-liquid transition HyA hydrogels. At monodentate-dominant liquid have low (HyA_L). mixed bonding, solid medium (HyA_M)....

Although a demineralized bone matrix (DBM) is often used as an alternative to autologous graft, its clinical application still hampered by easy dispersion of DBM particles and insufficient osteoinductivity in the defect site. Herein, we designed self-healing hydrogel for that can rapidly restore structural integrity after damage based on amino-rich black phosphorus (BP) nanosheets aldehyde-functionalized hyaluronic acid (AHA). Given increased expression morphogenetic protein (BMP)...

On-demand, ultrahigh precision delivery of molecules and cells assisted by scaffold is a pivotal theme in the field controlled release, but it remains extremely challenging for ceramic-based macroporous scaffolds that are prevalently used regenerative medicine. Sea sponges (Phylum Porifera), whose bodies possess hierarchical pores or channels organic/inorganic composite structures, can delicately control water intake/circulation therefore achieve high mass transportation food, oxygen,...

The fabrication strategies of three-dimensional porous biomaterials have been extensively studied and well established in the past few decades, yet biocompatibility versatility architecture preparation is still lacking. Herewith, we present a novel green 3D foam technique for both soft hard engineering. By utilizing gelatinization retrogradation properties starches, stabilized constructs made various building blocks, from living cells to ceramic particles, were created first time. In tissue...

Biodegradable polymer-based nanocomposite coatings provide multiple advantages to modulate the corrosion resistance and cytocompatibility of magnesium (Mg) alloys for biomedical applications. poly(glycerol sebacate) (PGS) is a promising candidate used medical implant In this study, we synthesized new PGS system consisting hydroxyapatite (HA) oxide (MgO) nanoparticles developed spray coating process produce layer on pretreated Mg substrates, which improved adhesion at interface their with...

Abstract Transparent cranial window to the brain is highly desirable for therapies because such implant would allow continuous monitoring of disorders and long‐term delivery photodynamic therapy into without repeated surgeries opening skull. Nanostructured yttria‐stabilized zirconia (YSZ) a potential candidate application its promising mechanical optical properties. In this study, new process using aerosol spray pyrolysis was established synthesizing 6–7 nm YSZ nanopowders with precisely...

Cells encapsulation by biomaterials has been widely studied as a strategy of building tissue construct in engineering. Conventional cells using hydrogels often needs the polymerization process or relatively complex molding process. In this study, we developed facile for situ fabrication biodegradable cell-laden starch foams. By utilizing unique gelatinization property starch, foams with tunable architecture were rapidly prepared green and biological-friendly The bubble size stiffness could...

Hepatocellular carcinoma (HCC), which is the third leading cause of cancer-related mortality in world, presents a significant medical challenge. Triptolide (TP) has been identified as an effective therapeutic drug for HCC. However, its precise mechanism still unknown. Understanding action TP against HCC crucial implementation field treatment. We hypothesize that anti-HCC actions might be related to modulation lipid metabolism given role plays promoting progression In this work, we first...

On-demand, ultra-high precision delivery of molecules and cells is great importance in the field controlled release. In article number 1600410, inspired by sea sponges, Lei Yang, Yuekun Lai, co-workers design fabricate a biomimetic macroporous ceramic composite sponge which reveals unique precise AND logic release behaviors response to dual-gates moisture pressure (or strain).

Transparent yttria-stabilized zirconia (YSZ) ceramics are promising for cranial window applications because of their good mechanical and optical properties as well biocompatibility. YSZ discs with different yttria concentrations were either processed via current-activated pressure-assisted densification (CAPAD) using commercial nanoparticles or densified spark plasma sintering (SPS) pyrolysis-synthesized in-house. This study provided critical results to screen composition, processing,...