A5020893716- Estrogen and related hormone effects
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- DNA and Nucleic Acid Chemistry
- Metal complexes synthesis and properties
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Economic and Financial Impacts of Cancer
- Cholesterol and Lipid Metabolism
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- bioluminescence and chemiluminescence research
Ministry of Health of the Russian Federation
2021-2024
Russian Cancer Research Center NN Blokhin
2005-2023
Background. Progesterone receptors (PR) are regulators of cell proliferation and therefore can be considered as an aim for targeted medications in the treatment oncological diseases. At same time, a quantitative assessment PR expression tissue non-small lung cancer (NSCLC), which has not yet been carried out other studies, will determine possibility using modulators this disease identify potential category patients most susceptible to these drugs. Purpose. To characterize NSCLC by indicators...
Quantitative assessment of estrogen receptors alpha (ERα) expression was carried out in 115 samples non-small cell lung cancer (NSCLC) by an immuno uorescent assay and ow cytometry. It has been shown that high level ERα ≥20% predicts higher aggressiveness NSCLC than at low <20%: median survival 78 mos follow-up is increased 1.5 times; the risk death reduced almost 2.0 times (p = 0.04). Time to average 18 about 20% patients with expression. The results validate informative value uorescence...
In the study of 125 patients after radical surgery for non-small cell lung cancer (NSCLC), distinctive clinicopathological parameters this disease were found. Thus, majority with NSCLC smokers (73%), men had significantly higher rate than women (80% vs 20%). Patients different sex varied by tumor histological type: squamous carcinoma was characteristic male (70%), while adenocarcinoma predominated in (80%). Authors conclude that described incidence patterns and association significant clinical...
Background. Estrogen receptors beta (ERβ) are an important biological regulator and target of antiestrogens, however, unlike estrogen alpha (ERɑ), their significance in the prognosis treatment breast cancer remains unclear. Purpose . Evaluation ERβ prognostic value comparative assessment frequency level marker expression groups with good poor by Ki-67 proliferative index score cancer. Methods (% cells expressing marker) 68 tissue samples was quantified immunofluorescence flow cytometry....