A5076180597- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- RNA modifications and cancer
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Cancer therapeutics and mechanisms
- Breast Cancer Treatment Studies
- Glycosylation and Glycoproteins Research
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Synthesis and biological activity
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Chemical Reactions and Isotopes
- DNA and Nucleic Acid Chemistry
- Metal complexes synthesis and properties
- Advanced Breast Cancer Therapies
- Microtubule and mitosis dynamics
Sechenov University
2020-2025
Ministry of Health of the Russian Federation
2016-2021
Russian Cancer Research Center NN Blokhin
2008-2020
Academy of Medical Sciences
1994-2014
Russian Academy of Sciences
1994-2014
Cancer Research Center
1995-2012
A new method of double immunofluorescent staining for flow cytometry has been created to evaluate quantitative expression mesenchymal protein vimentin only in epithelial cells a solid tumor that is mix different origin cells. De novo strongly associated with epithelial–mesenchymal transition and therefore metastatic potential marker In comparison semiquantitative available methods, the proposed one several advantages, such as accurate measurement marker's expression, minimization spatial...
Background. Progesterone receptors (PR) are regulators of cell proliferation and therefore can be considered as an aim for targeted medications in the treatment oncological diseases. At same time, a quantitative assessment PR expression tissue non-small lung cancer (NSCLC), which has not yet been carried out other studies, will determine possibility using modulators this disease identify potential category patients most susceptible to these drugs. Purpose. To characterize NSCLC by indicators...
Quantitative assessment of estrogen receptors alpha (ERα) expression was carried out in 115 samples non-small cell lung cancer (NSCLC) by an immuno uorescent assay and ow cytometry. It has been shown that high level ERα ≥20% predicts higher aggressiveness NSCLC than at low <20%: median survival 78 mos follow-up is increased 1.5 times; the risk death reduced almost 2.0 times (p = 0.04). Time to average 18 about 20% patients with expression. The results validate informative value uorescence...
Background. The cytoskeletal protein β-tubulin class III (Tubb3) is associated with tumor resistance to taxanes and vinca alkaloids, as well the metastatic potential of neoplasm, however, data from immunohistochemical analysis Tubb3 expression in non-small cell lung cancer (NSCLC) tissue are few contradictory. Purpose. Characterization level intensity NSCLC identified parameters correlation clinically significant characteristics disease. Methods. Quantitative assessment 120 surgical samples...
Discordant data on TUBB3 microtubule protein contribution to antitumor drug resistance and tumor metastatic potential as well expression prognostic value in non-small cell lung cancer, have been analyzed. The need of quantitative assessment methods, particular, immunofluorescence assay associated with flow cytometry, a component molecular diagnostics, is substantiated.
Most often, neuroendocrine carcinoma (NEC) is found in the gastrointestinal tract, broncho-pulmonary system, but they can also occur other organs, such as kidney, bladder, which of most interest because rarity this pathology. Until recently, there was not even a proper morphological classification for kidney NEC, and among some histological types, large cell only about 7 cases were recorded, independent bladder carcinoids, 15 cases. Currently, are no clinical features NEC fundamentally...