Vascular dysfunction is thought to play a major role in the development of diabetic cardiovascular disease. The roles endothelial dysfunction, oxidative stress, and dyslipidemia will be considered. Melatonin as well L-carnitine were shown possess strong antioxidant properties. Diabetes induced with high fat diet (for 8 weeks) multipl low doses intraperitoneal injection STZ (twice, 30mg/kg/d i.p). animals randomly assigned one experimental groups follows: Control group (C), (HFD), STZ-induced...

Oxidative stress plays an important role in the development of complications diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective present study was explore effects melatonin (MLT) on diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes induced streptozotocin, (STZ, 55 mg/kg/i.p) adult rats. MLT given 10 mg/kg/i.p once a day for 2 weeks beginning from sixth week. Six later, rats were divided into three groups: control...

Diabetes and insulin resistance frequently cause liver damage. also causes reduction in blood IGF-1 levels. We investigated the relation between damage levels diabetic rats. Fourteen Wistar albino rats were divided into control groups. was induced by streptozotocin. Rats sacrificed for biochemical histologic examinations 2 weeks after streptozotocin injection. Serum decreased, malondialdehyde (MDA) increased, glutathione peroxidase (GPx) enzymes activities decreased serum alanine...

AbstractStatins are lipid-lowering drugs that widely used for treating hyperlipidemia, especially in diabetic patients. The aim of our study was to explore the effects atorvastatin on oxidative stress and apoptosis sciatic nerve due hyperglycemia. Diabetes induced by streptozotocin. Atorvastatin given orally two weeks beginning from sixth week. Microscopic examination revealed normal tissue organization disrupted streptozotocin rats. Treatment with reduced histological damage protected...

The relationship between serum total testosterone (T) concentration and fluid intelligence (nonverbal, spatial) was studied in consistently right-handed men with successful (S) or unsuccessful educational levels (NS). Hand preference assessed by the Edinburgh Handedness Inventory. Nonverbal measured Cattell's Culture Fair Intelligence Test. Serum T level determined using chemiluminescence enzyme-immunoassay on hormone autoanalyzer. There no significant difference mean of S subjects NS...

The thermodilution method has been widely used to estimate cardiac output by injecting a cold solution into circulating blood. It is uncertain if radial heat transfer from the vascular/cardiac wall injectate can cause inaccurate results with this method. In study, we have introduced physical experimental model of without recirculation solution. To test accuracy method, setup included an aluminum tube allow transfer. Variations following parameters were conducted: (i) real flow rate, (ii)...

We assessed the time-dependent effects of intraperitoneal (i.p.) and intravenous (i.v.) application dexamethasone (Dexa) on mean arterial blood pressure (MAP), heart rate (HR) total volume (TBV). evaluated also relation between immunoreactivities transforming growth factor-beta (TGF-β), epithelial nitric oxide synthase (eNOS), interleukin-1 beta (IL1-β) vascular endothelial factor (VEGF) in rat brain, lung kidney tissues. Rats were anesthetized while still breathing spontaneously, a...

Paraquat (1,1'-dimethyl-4,4'-bipyridinium) (PQ), is a nonselective contact herbicide that highly toxic to humans. The kidney affected during PQ intoxication. Dexamethasone (Dexa) has anti-inflammatory effects and used treat cases of poisoning. We investigated in rat hemodynamic immunohistochemical characteristics Dexa treatment acute Adult male rats were divided into four groups: 1, untreated control; 2, treated with 100 mg/kg Dexa; 3, 25 PQ; 4, + Dexa. Mean arterial pressure (MAP) heart...

The asymmetrical breakdown of the blood-brain barrier (BBB) was studied in female rats. Paw preference assessed by a food reaching test. Adrenaline-induced hypertension used to destroy BBB, which evaluated using triphenyltetrazolium (TTC) staining brain slices just after giving adrenaline for 30 s. In normal rats, whole sections exhibited complete with TTC. After infusion s, there were large unstained areas left right-pawed animals, and vice versa left-pawed animals. Similar results obtained...

Adenosine has been commonly used to treat supraventricular tachycardia in clinics. However, there are only a few studies on the effects of adenosine ischemia or reperfusion induced arrhythmia and they conflict with results present study. During this study, we aimed clarify effect ischemia-reperfusion arrhythmia. Materials methods: Left coronary artery was ligated for 6 min it released 15 produce reperfusion. A1 agonist CCPA (2 Chloro - N6 Cyclopentyl-adenosine), selective antagonist DPCPX (8...

Dibutryl (DB) adenosine 3′,5′-cyclic monophosphate (cAMP) is an important modulator of physiological functions. To determine the protective effects DBcAMP on heart tissue, we evaluated changes in immunoreactivity endothelial nitric oxide synthase (eNOS), inducible (iNOS) and transforming growth factor-beta (TGF-β) left cervical vagotomized rats treated with DBcAMP. Male were divided into four groups. In Group 1, animals subjected to a vagotomy. 2 received 1 ml bolus injection 15 ml/kg...

Introduction: Increased membrane rigidity, decreased deformability and hemolysis in erythrocytes are the result of oxidative damage. Our study included patients diagnosed with anemia a control group healthy individuals these groups, it was aimed to measure level Nitric Oxide (NO), which is an indicator damage, determine superoxide dismutase enzyme (SOD) activity, most important components antioxidant system. Material Method: Ethics Committee approval obtained for who were iron deficiency...

Abstract Objectives Type 2 diabetes is a common metabolic disease and anxiety disorders are very among diabetics. Buspirone used in the treatment of anxiety, also having blood glucose-lowering effects. The aim study was to investigate effects buspirone on glucose lipid metabolism as well vascular function type diabetic rats. Methods A 2-diabetic model induced through high-fat diet for eight weeks followed by administration low-dose streptozotocin (35 mg/kg, intraperitoneal) given at two...

Background: Massive open online courses (MOOC) is a web-based application to transform the whole world into school environment.In this way, quality of education could be raised without discrimination.In 2018, 66 Family Practitioners and trainees attended "Improving Global Health: Focusing on Quality Safety" program simultaneously.The goal was benefit from visual written tools different countries age groups.The aim study evaluate benefits and/or educational needs after MOOC.Materials Methods:...