A5056141323- Marine Sponges and Natural Products
- Synthesis and biological activity
- Phytochemistry and Biological Activities
- Microbial Natural Products and Biosynthesis
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Genetics, Aging, and Longevity in Model Organisms
- Cholinesterase and Neurodegenerative Diseases
- Allelopathy and phytotoxic interactions
- Synthesis and Biological Activity
- Nigella sativa pharmacological applications
- Algal biology and biofuel production
- Seed Germination and Physiology
- Nanoparticle-Based Drug Delivery
- Protein Tyrosine Phosphatases
- Lipid Membrane Structure and Behavior
- Malaria Research and Control
- Seaweed-derived Bioactive Compounds
- Blood Pressure and Hypertension Studies
- Medicinal Plants and Neuroprotection
- Echinoderm biology and ecology
King Abdulaziz University
2020-2025
University of Arizona
2014
Presently, the world is under toll of pandemic coronavirus disease-2019 (COVID-19) outbreak caused by SARS-CoV-2. Lack effective and safe therapeutics has stressed scientific community for developing novel capable alleviating stopping this pandemic. Within presented study, molecular docking, ADME properties all-atom dynamic (MD) simulation, along with two standard antiviral agents (lopinavir benzopurpurin-4B), were applied to investigate 15 scalaranes sesterterpenes natural compounds,...
(Asteraceae) is a wild. edible plant that represents plentiful source of polyphenolic compounds. For the first time, metabolic analysis profiling demonstrated presence anthocyanidin glycosides, coumarins, flavonoids and their corresponding phenolic acids. The total compounds were determined to be 206.28 ± 14.64 mg gallic acid equivalent/gm, while 45.56 1.78 quercetin equivalent/gm. crude extract
The present work aimed to load propranolol hydrochloride (PN), a beta-blocking agent with low oral bioavailability, into PLGA-lipid hybrid nanoparticles (PLHNPs) for augmenting its efficacy. PLHNPs contain phospholipid (PC) in addition PLGA augment the potential of intranasal delivery and PN avoidance blood-brain barrier management migraine. were prepared by single emulsion/ solvent evaporation method then optimized applying 23 full factorial design using PC amount (mg) (X1), (X2), surface...
Introduction:Klebsiella pneumoniae (K. pneumoniae) and Pseudomonas aeruginosa (P. aeruginosa) are the most common Gram-negative bacteria associated with pneumonia coinfecting same patient. Despite their high virulence, there is no effective vaccine against them. Methods: In current study, screening of several proteins from both pathogens highlighted FepA OmpK35 for K. in addition to HasR OprF P. as promising candidates epitope mapping. Those four were linked form a multitope vaccine, that...
Background: Hepatocellular carcinoma (HCC) is one of the most widespread malignancies and reported as fourth prevalent cause cancer deaths worldwide. Therefore, we aimed to investigate probable mechanistic cytotoxic effect promising 2-thioxoimidazolidin-4-one derivative on liver cells using in vitro vivo approaches. The compounds were tested for activity MTT assay, compound was colony forming unit flow cytometric analysis, RT-PCR, Western blotting, SEC-carcinoma silico highlight virtual...
The Red Sea marine fungus Penicillium chrysogenum (Family: Ascomycota) comprises a panel of chemically diverse natural metabolites. A meleagrin alkaloid was isolated from deep-sediment-derived P. Strain S003 and has been reported to exert antibacterial cytotoxic activities. present study aimed explore the therapeutic potential on pulmonary fibrosis. Lung fibrosis induced in mice by single intratracheal instillation 2.5 mg/kg bleomycin. Mice were given 5 daily either for 3 weeks after...
A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 compound IC261, a dual casein kinase (CK1)/tubulin polymerization inhibitor, taking into consideration the pharmacophore required for EGFR-tyrosine inhibition. The new molecular entities provoked significant growth inhibition against PC-3, MCF-7 COLO-205 at 10 μM dose. Compounds 6-chloro-3-(2,4,6-trimethoxybenzylidene) indolin-2-one, 4b,...
The aim of this study was to evaluate the antiangiogenic and immunomodulatory potential sulfated polysaccharides from marine algae Macrocystis integrifolia characterized by FTIR. cytotoxicity evaluated using 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay. Antiangiogenic activity chicken chorioallantoic membrane (CAM) Immunomodulatory determined on macrophage functionality allergic response. results showed that significantly decreased angiogenesis in membranes (p <...
We investigated the antioxidant activity of total methanol extract C. speciosum leaves (CST), ethyl acetate (CSE), and remaining aqueous (CSR) fractions in vitro, vivo using Caenorhabditis elegans model, silico. LC-ESI-MS/MS analysis was employed for metabolic profiling CST. ADME/TOPAKT prediction performed to determine potential pharmacokinetic, pharmacodynamic, toxicity properties major identified phytoconstituents. All examined samples showed considerable where CST, CSE, CSR displayed...
Phytochemical investigation of chloroform fraction (DBC) and ethyl acetate (DBE) D. bupleuroides (Acanthaceae) resulted in the isolation β-sitosterol (1) from DBC vanillic acid (2) DBE, which were first to be isolated bupleuroides. β-Sitosterol exhibited substantial antioxidant activity (IC50 = 198.87 µg/mL), whereas showed significant power 92.68 µg/mL) employing 1,1-diphenyl-2-picrylhydrazyl (DPPH*) radical scavenging capacity assay. Both compounds pronounced antimicrobial using agar disc...
Euclea divinorum Hiern is a medicinal plant widely distributed in the northeast parts of South Africa. This has been used to treat miscarriage and alleviate gastrointestinal problems. It can also be externally for treatment ulcers gonorrhea. In this study, we investigated phytochemical composition E. leaf extract using LC-MS explored its antioxidant properties vitro vivo. The total polyphenolic content was determined by Folin-Ciocalteu method. DPPH FRAP assays were employed confirm plant's...
Cancer is the leading cause of death globally, with an increasing number cases being annually reported. Nature-derived metabolites have been widely studied for their potential programmed necrosis, cytotoxicity, and anti-proliferation to enrichment modern medicine, particularly within last couple decades. At a more rapid pace, concept multi-target agents has evolved from innovative approach into regular drug development procedure hampering multi-fashioned pathophysiology high-resistance...
Germination models are really useful in predicting seed germination, attributed to their application economic crop management. Hence, we evaluated cardinal temperatures (Ts), germination behavior, and model coefficients of fenugreek under varying (Ts; 10, 20, 30, 40 °C) water potentials (ψs 0, −0.01, −0.02, −0.05 MPa). We observed that the maximum minimum hydrotime constant (θH) values at 20 °C, respectively. The base potential 50 percentiles (Ψb 50) exhibited an asymmetrical pattern with...
Chemical investigation of the ethyl acetate extract Penicillium chrysogenum strain S003, a fungus isolated from Red Sea deep sediment, led to isolation cerebroside molecular species LAMA (1) along with three other known compounds, ergosterol (2), epidioxyergosterol (3), and kojic acid (4). The structures compounds were elucidated by interpretation spectral data, including detailed 1D 2D NMR (One two dimensional Nuclear Magnetic Resonance) mass spectrometry. cytotoxic activities 1-4 against...
Phragmanthera austroarabica (Loranthaceae), a semi-parasitic plant, is well known for its high content of polyphenols that are responsible antioxidant and anti-inflammatory activities. Gallic acid, catechin, methyl gallate bioactive metabolites common occurrence in the family Loranthaceae. Herein, concentrations these were assessed using high-performance thin layer chromatography (HPTLC). Methyl gallate, gallic acid scanned at 280 nm. Their as 14.5, 6.5 43.6 mg/g plant dry extract,...
Phytochemical characterization of the ethyl acetate fraction Saussurea hypoleuca root extract resulted in isolation oleic acid (1) and luteolin (2), which were isolated for first time from root. A heavy metal analysis powder performed using atomic absorption spectroscopy showed that contents iron, cadmium, lead, zinc, nickel, copper within certified limits according to WHO guidelines. Differential scanning calorimetry (DSC) revealed its crystalline amorphous nature; meanwhile,...