A5100709940- Cancer-related molecular mechanisms research
- Muscle metabolism and nutrition
- Immune cells in cancer
- Cell death mechanisms and regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer Genomics and Diagnostics
- Force Microscopy Techniques and Applications
- Proteoglycans and glycosaminoglycans research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Platelet Disorders and Treatments
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cellular Mechanics and Interactions
- Winter Sports Injuries and Performance
- Glycosylation and Glycoproteins Research
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
- Circular RNAs in diseases
First Hospital of Jilin University
2023
Jilin University
2023
Affiliated Hospital of Hebei University
2021
Incyte (United States)
2018
Shougang (China)
2017
Changchun Institute of Applied Chemistry
2017
Chinese Academy of Sciences
2017
University of Chinese Academy of Sciences
2017
Johnson & Johnson (United States)
2014
Guangdong Ocean University
2013
Introduction The causal relationship between inflammatory factors and stroke subtypes remains unclear. This study aimed to analyze the 41 these two using Mendelian randomization (MR). Methods We performed a two-sample MR analysis assess effects of cytokines on its conducted genome-wide association (GWAS) data. inverse-variance weighted (IVW) method was adopted as main method, we series randomizations related sensitivity analyses. Results indicated some suggestive evidences: IVW approach,...
Chronic inflammation orchestrates the tumor microenvironment and is strongly associated with cancer. Tumor necrosis factor- α (TNF ) involved in invasion metastasis by inducing epithelial to mesenchymal transition (EMT). This process defined loss of characteristics gain traits. The mechanisms TNF -induced EMT cancer cells have been well studied. However, mechanical properties not yet probed. In this work, atomic force microscopy (AFM) was applied investigate morphology HCT116 human colon...
Intetumumab is a fully human monoclonal antibody that inhibits αv integrins. It has been shown in vitro assays to effectively inhibit cell viability, metastasis, and adhesion of cancer cells endothelial cells. However, the response varies different tumor lines. To understand growth inhibition mechanism identify molecular signature can predict sensitivity, we focused on lung lines performed series proliferation assays. We then assessed global gene expression profiles, DNA copy number...
Abstract The primary cause of cancer associated mortality is tumor metastasis. concept the pre-metastatic niche supported by evidence changes at distal sites that create a permissive environment to allow disseminated cells seed. Myeloid-derived suppressor (MDSCs) remodel microenvironment and function as immunosuppressive promote growth. Previously, we demonstrated clinical stage LSD1 specific inhibitor, INCB059872 significantly reshaped myeloid compartment in murine 4T1 syngeneic model...
Purpose: Alisol A is a bioactive triterpenoid isolated from the Rhizoma Alismatis.Previous studies have shown that alisol has anticancer potential.In this study, we explored effect of on growth nasopharyngeal carcinoma (NPC) cells.Materials and Methods: MTT assay, colony formation flow cytometry, transwell wound healing western blotting were used to assess cell viability, proliferation, cycle, migration, invasion, protein expression, respectively, in vitro.AutoDock Vina Discovery Studio...
Objective To investigate the relationship between changes of bone marrow megakaryocyte count and therapeutic effect in adults with immune thrombocytopenia. Methods From January 2009 to June 2013, 140 adult thrombocytopenia patients were selected as research objects, all performed smears before treatment, number 35/cm2 classified group Ⅲ, three groups treated same solution, treatment effects compared. Results The total effective rate I, Ⅱ Ⅲ was 25.00%, 76.47% 93.33%, difference...