About
Contact & Profiles
A5100605700
Research Areas
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
Max Planck Institute for Heart and Lung Research
2023
Abstract Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from glycolysis to fatty acid oxidation, chromatin reconfiguration and exit the cell cycle, instating barrier for adult heart regeneration 1,2 . Here, explore whether reprogramming can overcome this enable regeneration, we abrogate oxidation in inactivation Cpt1b We find that disablement improves resistance hypoxia stimulates cardiomyocyte proliferation, allowing after ischaemia–reperfusion injury....
10.1038/s41586-023-06585-5
article
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cc-by
Nature
2023-09-27
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