A5056841635- Balance, Gait, and Falls Prevention
- Regulation of Appetite and Obesity
- Muscle activation and electromyography studies
- Motor Control and Adaptation
- Electrolyte and hormonal disorders
- Neuroendocrine regulation and behavior
- Biochemical Analysis and Sensing Techniques
- Parkinson's Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Retinal and Macular Surgery
- Pancreatic function and diabetes
- Plant Molecular Biology Research
- Receptor Mechanisms and Signaling
- Cerebral Palsy and Movement Disorders
- Intraocular Surgery and Lenses
- Neuroscience and Music Perception
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Ion Transport and Channel Regulation
- Plant Reproductive Biology
- Sports Performance and Training
- Microbial Metabolic Engineering and Bioproduction
- Lower Extremity Biomechanics and Pathologies
- Neurogenesis and neuroplasticity mechanisms
Fujita Health University
2014-2024
Harvard University
2022
Cosmo Oil (Japan)
1999-2021
Tohoku Bunka Gakuen University
2000-2016
Fujita Health University Hospital
2016
Nagoya University
2006-2015
The University of Tokyo
2006-2015
Czech Academy of Sciences, Institute of Physiology
2002-2009
Kochi Medical School Hospital
1992-2007
University of California, Irvine
2006
Abstract Some phytohormones such as gibberellins (GAs) and cytokinins (CKs) are potential targets of the KNOTTED1-like homeobox (KNOX) protein. To enhance our understanding KNOX protein function in plant development, we identified rice (Oryza sativa) genes for adenosine phosphate isopentenyltransferase (IPT), which catalyzes rate-limiting step CK biosynthesis. Molecular biochemical studies revealed that there eight IPT genes, OsIPT1 to OsIPT8, genome, including a pseudogene, OsIPT6....
The shoot apical meristem (SAM) is a group of stem cells that are responsible for plant development. Mutations in rice SHOOTLESS2 ( SHL2 ), SHL4/SHOOT ORGANIZATION2 SHO2 and SHO1 cause complete deletion or abnormal formation the SAM. In this study we showed defects SAM shl mutants associated with loss expression homeodomain–leucine zipper HD-ZIPIII ) family genes. Rice , SHL4/SHO2 encoded orthologues Arabidopsis RNA-dependent RNA polymerase 6, ARGONAUTE (AGO) 7, DICER-like 4, respectively,...
Summary The Arabidopsis WUSCHEL (WUS) protein, which plays an important role in the specification of stem cells shoot apical meristem (SAM), contains ‘atypical’ homeodomain (HD) with extra residues its loop and turn regions. We speculated that a WUS‐type atypical HD protein might also be involved maintenance root (RAM) rice. To investigate this possibility, we isolated characterized rice WUS ‐type homeobox gene designated q uiescent‐center‐specific h omeo b ox ( QHB ) gene. Using...
The optimal condition in speed, step rate, and length of human walking has been reported terms temporal consistency, energy cost, attentional demand. No study, however, conducted on the spatial variability walking. This study examined whether there is an speed with minimum intrasubject width during free walk (experiment 1) rate imposed rates 2). Wearing shoes ink-applied felt squares attached to heels, healthy students walked a flat walkway (0.6 x 16 m) at five different speeds freely chosen...
Drug addiction is mediated by complex neuronal processes that converge on the shell of nucleus accumbens (NAcSh). The NAcSh receives inputs from lateral hypothalamus (LH), where self-stimulation can be induced. Melanin-concentrating hormone (MCH) produced mainly in LH, and its receptor (MCH1R) highly expressed NAcSh. We found that, NAcSh, MCH1R coexpressed with dopamine receptors (D1R D2R), MCH increases spike firing when both D1R D2R are activated. Also, injecting potentiates...
The pituitary is a major hormone center that secretes systemic hormones responding to hypothalamus-derived-releasing hormones. Previously, we reported the independent induction and hypothalamic differentiation of human embryonic stem cells (ESCs). Here, functional hypothalamic-pituitary unit generated using induced pluripotent (iPS) in vitro. adrenocorticotropic (ACTH) secretion capacity reached comparable level adult mouse because simultaneous maturation with neurons within same aggregates....
A tapping test in which the tasks required a synchronous response to periodic sound signal by finger was performed 27 normal subjects and 146 patients with Parkinson's disease. Some could not maintain at critical frequency of 2.5 or 5 Hz (taps per second) showed hastened ∼ 6 Hz, independent input frequencies, i.e., ‘hastening phenomenon.’ The other respond synchronously up 7 Hz. Autocorrelational analysis sequential intervals suggested that synchronized feedback control as target except...
Recent studies suggest that the AMP-activated protein kinase (AMPK) signaling in hypothalamus is master regulator of energy balance. We reported previous glucocorticoids play a permissive role regulation orexigenic neuropeptide Y (Npy) gene expression arcuate nucleus. In this study, we examined whether any cross talk occurs between and AMPK to regulate Npy as well agouti-related peptide (Agrp) hypothalamic organotypic cultures, addition medium activator,...
Journal Article Histopathologic Studies on Liver Tumorigenesis Induced in Mice by Technical Polychlorinated Biphenyls and Its Promoting Effect Tumors Benzene Hexachloride Get access Nobuyuki Ito, M.D., M.D. 3Cancer Center Institute, Nara Medical University, Kashihara, 634, Japan Search for other works this author on: Oxford Academic PubMed Google Scholar Hiroshi Nagasaki, 4Department of Hygiene, Masayuki Arai, Sachio Makiura, Seiichi Sugihara, Kazuya Hirao, JNCI: the National Cancer Volume...
In this study we aimed to identify the physiological roles of G protein‐coupled receptor 84 (GPR84) in adipose tissue, together with medium‐chain fatty acids (MCFAs), specific ligands for GPR84. mice, high‐fat diet up‐regulated GPR84 expression fat pads. 3T3‐L1 adipocytes, co‐culture a macrophage cell line, RAW264, or TNFα remarkably enhanced expression. presence TNFα, MCFAs down‐regulated adiponectin mRNA adipocytes. Taken together, our results suggest that emerges adipocytes response from...
Leaf shape is one of the key determinants plant architecture. also affects amount sunlight captured and influences photosynthetic efficiency; thus, it an important agronomic trait in crop plants. Understanding molecular mechanisms governing leaf a central issue developmental biology agrobiotechnology. Here, we characterized narrow-leaf phenotype FL90, linkage tester line rice (Oryza sativa). Light scanning electron microscopic analyses FL90 leaves revealed defects development marginal...
Walking patterns and rhythmic movement of the fingers were examined in a total 1,134 male female community residents 65 years age over. characterized according to ratio step length divided by rate (cadence), called Walk Ratio, during level walking at preferred maximum speeds. The pattern tended change age; older subjects walked with shorter steps (smaller Ratio). Rhythmic was using finger-tapping test time sound 4-Hz metronome. Hastened tapping or finger festination, which subject tapped...
The rice KNOX protein OSH15 consists of four conserved domains: the MEINOX domain, which can be divided into two subdomains (KNOX1 and KNOX2); GSE domain; ELK homeodomain (HD). To investigate function each we generated 10 truncated proteins with deletions in domains mutations amino acids HD. Transgenic analysis suggested that KNOX2 HD are essential for inducing abnormal phenotype KNOX1 affect severity. We also found both necessary homodimerization only is needed binding to its target...
Neuropeptide Y (NPY) in the arcuate nucleus is an orexigenic hormone of which levels are regulated by humoral as well neural signals. In this study, we examined regulation NPY gene expression hypothalamic organotypic cultures. Dexamethasone (DEX) (10 –9 to 10 –7 m ) significantly increased mRNA expression, and effects were not influenced coincubation with sodium channel blocker tetrodotoxin (TTX), indicating that action DEX independent potentials. Conversely, insulin –11 inhibited stimulated...
Ghrelin, which was identified from the rat stomach, is a potent stimulant for food intake. Several lines of evidence suggest that orexigenic action ghrelin mediated via neuropeptide Y (NPY) neurons in arcuate nucleus, although detailed mechanisms by stimulates NPY are not clear. In this study, we examined gene regulation and agouti-related peptide (AGRP), another synthesized neurons, nucleus hypothalamic organotypic cultures. Incubation explants with significantly increased AGRP mRNA...
The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes. We investigated role S100B interaction between adipocytes macrophages using a cell-culture model.RAW264.7 (RAW) were stimulated by recombinant to observe alterations TNF-α M1 markers; 3T3-L1 (L1) examine secretion. RAW L1 then mutually with conditioned media each other, or co-cultured. effects silencing...
Familial central diabetes insipidus is an autosomal dominant disease caused by a deficiency of arginine vasopressin (AVP). We previously reported three distinct mutations in the AVP gene Japanese familial pedigrees that result substitution Ser for Gly57 neurophysin-II (NPII) moiety precursor, Thr Ala at COOH-terminus signal peptide, and deletion Glu47 NPII moiety. In this study, we analyzed two direct sequencing polymerase chain reaction-amplified DNA found novel exon 2, which encodes part...
Clinical features of 57 eyes with proliferative vitreoretinopathy (primary PVR) that developed preoperatively were statistically analyzed and compared a control group 1353 non-PVR rhegmatogenous retinal detachment. The significant (P <0.05) factors predisposing to PVR as follows: detachment for more than 1 month; aphakia (47.4% in the versus 11.1% group); vitreous hemorrhage (26.3% 11.0%); giant tear (15.8% 0.8%); breaks larger 3 disc diameters (62.1% 27.3%); horseshoe (65.5% 44.9%). RETINA...
Rapid correction of chronic hyponatremia can lead to osmotic demyelination syndrome (ODS), a severe disease. The microglia that accumulate in the demyelinative lesions may play detrimental role pathogenesis ODS by producing proinflammatory cytokines, suggesting they be target for therapeutic intervention. Here, we investigated whether minocycline, selective and potent inhibitor microglial activation, could protect against rats. We induced liquid diet feeding dDAVP infusion. 7 days later...