Tara Sadoway
A5061808839- Genetics and Neurodevelopmental Disorders
- Allergic Rhinitis and Sensitization
- Genomics and Rare Diseases
- Asthma and respiratory diseases
- Epilepsy research and treatment
- Environmental DNA in Biodiversity Studies
- Contact Dermatitis and Allergies
- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Isotope Analysis in Ecology
- Indigenous Studies and Ecology
- Olfactory and Sensory Function Studies
- RNA modifications and cancer
- Food Allergy and Anaphylaxis Research
- Genomic variations and chromosomal abnormalities
- Mitochondrial Function and Pathology
- Building materials and conservation
- Metabolism and Genetic Disorders
- Social Media in Health Education
- Peptidase Inhibition and Analysis
- Indoor Air Quality and Microbial Exposure
- Microbial Community Ecology and Physiology
- Artificial Intelligence in Healthcare and Education
- MicroRNA in disease regulation
- Geology and Paleoclimatology Research
University Health Network
2019-2023
University of Toronto
2019-2023
Hospital for Sick Children
2021-2022
McMaster University
2019-2021
Toronto Western Hospital
2020-2021
Faculty of 1000 (United States)
2021
Krembil Foundation
2019
Inflamax Research (Canada)
2015-2017
Thompson Rivers University
2012
Abstract The temporal and spatial coarseness of megafaunal fossil records complicates attempts to disentangle the relative impacts climate change, ecosystem restructuring, human activities associated with Late Quaternary extinctions. Advances in extraction identification ancient DNA that was shed into environment preserved for millennia sediment now provides a way augment discontinuous palaeontological assemblages. Here, we present 30,000-year sedimentary (sedaDNA) record derived from...
Copy number variants (CNV) are established risk factors for neurodevelopmental disorders with seizures or epilepsy. With the hypothesis that seizure share genetic factors, we pooled CNV data from 10,590 individuals disorders, 16,109 clinically validated epilepsy, and 492,324 population controls identified 25 genome-wide significant loci, 22 of which novel such as deletions at 1p36.33, 1q44, 2p21-p16.3, 3q29, 8p23.3-p23.2, 9p24.3, 10q26.3, 15q11.2, 15q12-q13.1, 16p12.2, 17q21.31, duplications...
Abstract Sedimentary ancient DNA (sedaDNA) has been established as a viable biomolecular proxy for tracking taxon presence through time in local environment, even the total absence of surviving tissues. SedaDNA is thought to survive mineral binding, facilitating long-term preservation, but also challenging isolation. Two common limitations sedaDNA extraction are carryover other substances that inhibit enzymatic reactions, and loss authentic when attempting reduce inhibitor co-elution. Here,...
Abstract Cytogenic testing is routinely applied in most neurological centres for severe paediatric epilepsies. However, which characteristics of copy number variants (CNVs) confer epilepsy risk and subtypes carry the CNV burden, have not been explored on a genome-wide scale. Here, we present largest investigation to date with 10 712 European cases 6746 ancestry-matched controls. Patients genetic generalized epilepsy, lesional focal non-acquired developmental epileptic encephalopathy were...
Volcanic caves have been little studied for their potential as sources of novel microbial species and bioactive compounds with new scaffolds. We present the first study volcanic cave microbiology from Canada suggest that this habitat has great isolation substances. Sample locations were plot ted on a contour map was compiled in ArcView 3.2. Over 400 bacterial isolates obtained Helmcken Falls Wells Gray Provincial Park, British Columbia. From our preliminary screen, tested, 1% showed activity...
Abstract Objective Dravet syndrome (DS) is a rare cause of severe and pharmacoresistant epileptic encephalopathy. Stiripentol (STP) has significant therapeutic benefit in the pediatric DS population. However, STP effects on adult patients have not been well studied. In our STP‐naive patient population, initiation was associated with encephalopathy, despite decreases valproate clobazam dosage. Here we explored treatment encephalopathic manifestations adults. Methods Twenty‐eight confirmed...
Analyses of few gene-sets in epilepsy showed a potential to unravel key disease associations. We set out investigate the burden ultra-rare variants (URVs) comprehensive range biologically informed presumed be implicated epileptogenesis. The 12 URV types 92 was compared between cases and controls using whole exome sequencing data from individuals European descent with developmental epileptic encephalopathies (DEE, n = 1,003), genetic generalized (GGE, 3,064), or non-acquired focal (NAFE,...
Abstract Epilepsies are a group of common neurological disorders with substantial genetic basis. Despite this, the molecular diagnosis epilepsies remains challenging due to its heterogeneity. Studies utilizing whole-genome sequencing may provide additional insights into causes unknown aetiology. Whole-genome was used evaluate cohort adults unexplained developmental and epileptic encephalopathies (n = 30), for whom prior tests, including whole-exome in some cases, were negative or...
Summary Ancient environmental DNA has been established as a viable biomolecular proxy for tracking taxonomic presence through time in local environment, even the total absence of primary tissues. It is thought that sedimentary ancient (sedaDNA) survives mineral binding. And while these organo-mineral complexes likely facilitate long-term preservation, they also challenge our ability to release and isolate target molecules. Two limitations sedaDNA extraction impede many palaeoenvironmental...
<b><i>Background:</i></b> Nonallergic vasomotor rhinitis (NAVMR) has been considered a diagnosis by exclusion due to unknown mechanisms or lack of diagnostic biomarkers. <b><i>Methods:</i></b> To determine clinical responses and biological pathways in NAVMR subjects challenged cold dry air (CDA) an environmental exposure chamber (EEC) pre- posttreatment with azelastine/fluticasone (AzeFlu), 30 subjects, prescreened for CDA-induced symptoms...
Abstract Sequencing-based studies have identified novel risk genes for rare, severe epilepsies and revealed a role of rare deleterious variation in common epilepsies. To identify the shared distinct ultra-rare genetic factors epilepsies, we performed whole-exome sequencing (WES) analysis 9,170 epilepsy-affected individuals 8,364 controls European ancestry. We focused on three phenotypic groups; but developmental epileptic encephalopathies (DEE), commoner phenotypes generalized epilepsy (GGE)...
<b>Introduction:</b> The controlled allergen exposure to patients in EECs allows for the direct comparison of perennial and seasonal allergies asthma. Comorbidity between allergic rhinitis asthma is high allergens like house dust mite cat. Our previous EEC studies support this finding. <b>Objective:</b> To examine symptoms scores reported with or without mild moderate exposed birch an record incidence severity observed EEC. <b>Methods:</b> 255 subjects, asthma, were screened allergy based on...
This study aims to analyze LGS patients for potential gene mutations contributing the phenotype, and identify participant characteristics that may prognosticate seizure functional outcomes in adulthood.