A5100382158- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Genomics, phytochemicals, and oxidative stress
- Psoriasis: Treatment and Pathogenesis
- Bone health and treatments
- Gut microbiota and health
- Genomics and Rare Diseases
- Growth Hormone and Insulin-like Growth Factors
- Genomics and Phylogenetic Studies
- Parathyroid Disorders and Treatments
- Biological Research and Disease Studies
- Autoimmune and Inflammatory Disorders Research
- Bioactive Compounds and Antitumor Agents
- Bone health and osteoporosis research
- Genetic diversity and population structure
- Microbial Metabolites in Food Biotechnology
- Insect and Arachnid Ecology and Behavior
- Probiotics and Fermented Foods
- Prion Diseases and Protein Misfolding
- DNA Repair Mechanisms
- Thyroid Disorders and Treatments
- Virus-based gene therapy research
- Lepidoptera: Biology and Taxonomy
- Dermatological and Skeletal Disorders
- Viral Infectious Diseases and Gene Expression in Insects
Pukyong National University
2011-2025
National Institute of Biological Resources
2020-2025
University of Massachusetts Lowell
2023-2024
Hallym University
2007-2024
Advanced Institute of Convergence Technology
2024
Seoul National University
2016-2024
Eli Lilly (United States)
2019-2023
Kyung Hee University
2019-2023
Texas A&M University
2004-2022
Rural Development Administration
2021
Objectives Previous studies have identified various bacterial taxa that are altered in cats with chronic enteropathies (CE) vs healthy cats. Therefore, the aim of this study was to develop a targeted quantitative molecular method evaluate fecal microbiota Methods Fecal samples from 80 client-owned and 68 CE were retrospectively evaluated. A panel PCR (qPCR) assays used measure abundance total bacteria seven taxa: Bacteroides, Bifidobacterium, Clostridium hiranonis, Escherichia coli,...
The interrelation between TSH, thyroid hormones and metabolic parameters is complex has not been confirmed. This study aimed to determine the association of TSH in euthyroid subjects relationship function risk factors. Furthermore, this examined whether predictive power for syndrome.This a cross-sectional that included medical health check-up programme at single institution.The 132 346 participants (66 991 men 65 355 women) aged over 18 years who had free T4 (FT4) T3 (FT3) levels within...
The pathogenic mechanisms of human autosomal dominant polycystic kidney disease (ADPKD) have been well known to include the mutational inactivation PKD2. Although haploinsufficiency and loss heterozygosity at Pkd2 locus can cause cyst formation in mice, polycystin-2 is frequently expressed renal ADPKD, raising possibility that deregulated activation PKD2 may be associated with cystogenesis ADPKD. To determine whether increased expression physiologically pathogenic, we generated...
Abstract Recombinant adeno‐associated virus (rAAV) vectors are a promising platform for in vivo gene therapies. However, cost‐effective, well‐characterized processes necessary to manufacture rAAV therapeutics challenging develop without an understanding of how process parameters (PPs) affect product quality attributes (PQAs). In this work, central composite orthogonal experimental design was employed examine the influence four PPs transient transfection complex formation...
The origin recognition complex (ORC) is an essential component of the prereplication (pre-RC) in mitotic cell cycles. role ORC as a foundation to assemble pre-RC conserved from yeast human. Furthermore, metazoans plays key determining timing replication initiation and usage. In this report we have produced analyzed Drosophila orc1 allele investigate roles ORC1 three different modes DNA during development. As expected, for proliferation brains imaginal discs, well gene amplification ovarian...
3,3′-Diindolylmethane (DIM) is a major in vivo derivative of indole-3-carbinol, which present cruciferous vegetables and has been reported to possess anti-carcinogenic properties. In the study, we examined whether DIM inhibits development prostate cancer using transgenic adenocarcinoma mouse (TRAMP) model. feeding inhibited carcinogenesis TRAMP mice, reduced number cells expressing SV40 large tumor antigen proliferating cell nuclear antigen, increased terminal dUTP nick-end labeling-positive...
Abstract Background Autoimmune thyroiditis is one of common organ‐specific autoimmune disease. The aim this study was to observe the effect adipose tissue derived mesenchymal stem cells (ATMSC) and CTLA4Ig gene‐transduced ATMSC on thyroiditis. Methods Experimental induced by immunization with thyroglobulin. Animals were divided into three groups: (i) a half million human ATMSC, (ii) murine CLTA4Ig (CTLA4Ig‐MSC), or (iii) normal saline (as control), which administered intravenously four times...
ABSTRACT Aedes albopictus is an important vector of various arboviruses, including dengue virus (DENV). The capacity for DENV has been studied in geographical regions, but information on Korean Ae. strains are limited. This study aimed to investigate the strain (Korea Disease Control and prevention Agency, KDCA) DENV‐2. Adult mosquitoes were orally infected with DENV‐2 dissected days 3 7 post‐infection. Viral RNA was extracted from midgut carcass tissues detected by RT‐PCR. results showed...
Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy, is a rare genetic disease affecting both skin and bones. Both autosomal dominant with incomplete penetrance recessive inheritance of PDP have been previously confirmed. Recently, hydroxyprostaglandin dehydrogenase (HPGD) solute carrier organic anion transporter family member 2A1 (SLCO2A1) were reported as pathogenic genes responsible for PDP. are involved in prostaglandin E2 (PGE2) degradation. We aimed to identify the...
Vespa mandarinia found in the forests of East Asia, including Korea, occupies highest rank arthropod food web within its geographical range. It serves as a source nutrition form amino acid mixture and is listed threatened species, although no conservation measures have been implemented. Here, we performed de novo assembly V. transcriptome by Illumina HiSeq 4000 sequencing. Over 60 million raw reads 59,184,811 clean were obtained. After assembly, total 66,837 unigenes clustered, 40,887,...
To evaluate the effect of withdrawing ixekizumab in patients with psoriatic arthritis (PsA) whom minimal disease activity (MDA) has been achieved after open-label treatment.SPIRIT-P3 was a multicenter, randomized, double-blind withdrawal study biologic treatment-naive adult PsA who were treated for 36 weeks (160 mg at week 0, then 80 every 2 weeks). Patients MDA sustained >3 consecutive months randomized 1:1, between and 64, to undergo blinded treatment (placebo) or continue up 104. The...
Abstract Introduction/objectives To evaluate the three-year efficacy and safety of ixekizumab with without concomitant conventional synthetic disease-modifying antirheumatic drug (csDMARD) use in patients active psoriatic arthritis (PsA). Method Patients PsA who were biologic-naïve (SPIRIT-P1, NCT01695239) or had prior inadequate response to tumor necrosis factor inhibitors (SPIRIT-P2, NCT02349295) randomized receive 80-mg every four weeks after receiving 160-mg at baseline. Efficacy,...
Differences in psoriatic arthritis (PsA) treatment response between sexes for ixekizumab, an interleukin-17A antagonist, are largely unexplored. This analysis used data from randomized clinical trials (RCTs) evaluating ixekizumab to study differences male and female patients with PsA.We pooled enrolled SPIRIT-P1 SPIRIT-P2 (NCT01695239 NCT02349295, respectively), phase 3 RCTs every 4 2 weeks active PsA. Subgroups of were defined by sex (male, female). Efficacy was measured the proportion...
Soy-isoflavones may act as estrogenic agonists or antagonists depending on the endogenous hormone status. These clinical effects can be exerted variably in individuals by metabolic ability to produce a more potent metabolite than precursors. The objective of this randomized, double-blind, placebo-controlled study was investigate skeletal effect isoflavones according their variability premenopausal women. Volunteers were randomly assigned receive either soy-extract (n=32) lactose (n=21) once...
A stand-alone BLAST server is available that provides a convenient and amenable platform for the analysis of molluscan sequence information especially EST sequences generated by traditional sequencing methods. However, it found has limitations in annotation using next-generation (NGS) platforms due to inconsistencies at NCBI. We constructed web-based interface new BLAST, called PANM-DB (Protostome DB) NGS data. The includes amino acid from protostome groups-Arthropoda, Nematoda, Mollusca...
Ranunculus sceleratus (family: Ranunculaceae) is a medicinally and economically important plant; however, gaps in taxonomic species identification limit its practical applicability. This study aimed to sequence the chloroplast genome of R. from Republic Korea. Chloroplast sequences were compared analyzed among species. The was assembled Illumina HiSeq 2500 sequencing raw data. 156,329 bp had typical quadripartite structure comprising small single-copy region, large two inverted repeats....
Activating mutations of the calcium-sensing receptor (CASR) gene are associated with autosomal dominant hypocalcemia (ADH) characterized by benign hypocalcemia, inappropriately low (PTH) levels and mostly hypercalciuria. Herein, we report a novel activating mutation in CASR Korean family ADH.The was sequenced patient ADH. The identified were also evaluated patient's members PCR-based sequencing. For functional studies, examined phosphorylation ERK1/2. In addition, intracellular Ca(2+)...
Gonadotropin-releasing hormone (GnRH) agonist has been used in the treatment of a wide variety sex-hormone-related diseases, as administration GnRH can alter secretion gonadotropin and sex hormones. Recently, we found that long-acting aggravated hyperthyroidism induced painless thyroiditis. This is first report to demonstrate association thyroid dysfunction with injection Korea. Here, three cases emphasize clinical importance this aggravating factor autoimmune disease.
Reactive oxygen species (ROS) and antioxidants are associated with maintenance of cellular function metabolism. Nuclear factor-E2-related factor 1 (NFE2L1, Nrf1) is known to regulate the expression a number genes involved in oxidative stress inflammation. The purpose this study was examine effects NFE2L1 on response osteoblastic MC3T3-E1 cells.The murine calvaria-derived cell line exposed lipopolysaccharide (LPS) for induction. were evaluated using small interfering RNA (siRNA) mRNA. ROS...