A5034670924- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Gallbladder and Bile Duct Disorders
- Microbial Natural Products and Biosynthesis
- Genetics and Neurodevelopmental Disorders
- Cystic Fibrosis Research Advances
- Oral and gingival health research
Northwestern University
2021-2022
Hartford Financial Services (United States)
2017
Hartford Public Library
2017
Closely related species are typically assumed to demonstrate similar phenotypes driven by underlying conserved genotypes. When monitoring for the effect of antimicrobials on types that may be selected for, this assumption prove incorrect, and identification additional genetic markers necessary.
Resistance to antipseudomonal penicillins and cephalosporins is often driven by the overproduction of intrinsic β-lactamase AmpC. However, OXA-10-family β-lactamases are a rich source resistance in Pseudomonas aeruginosa. OXA have propensity for mutation that leads extended spectrum cephalosporinase carbapenemase activity. In this study, we identified isolates from subclade multidrug-resistant (MDR) high risk P. aeruginosa clonal complex CC446 with ceftazidime. A genomic analysis revealed...
Purpose: Mortality associated with Pseudomonas aeruginosa bloodstream infection (PABSI) remains high despite advances in clinical care and therapeutics. In a recent study using mice to model PABSI, the gallbladder (GB) was identified as reservoir for bacterial expansion. Furthermore, bile exposure has been linked increased antimicrobial resistance (AMR). Therefore, we asked whether patients retained gallbladders might suffer from more resistant P. (Pa) infections, extended culture...
Rett Syndrome affects about one in every 10,000 to 15,000 births. It is a genetic neurodevelopmental disorder that mainly occurs females. Affected males die infancy because the syndrome exhibits an X‐linked dominant pattern of inheritance. caused by mutations Methyl CpG binding protein 2 (MeCP2) coding gene. MeCP2 necessary for epigenetic regulation gene expression. This represses transcription acting as molecular bridge between methylated DNA and complex co‐repressor proteins including...
Abstract Background Pseudomonas aeruginosa (PA) readily acquires genomic mutations and exogenous genetic elements that confer antimicrobial resistance (AMR). With the rise in AMR, there are limited antibiotics available to treat multidrug-resistant (MDR) PA. As such, clinicians have returned previously used antibiotics. Colistin, sidelined for neurotoxicity nephrotoxicity, has clinical practice as a viable but suboptimal option MDR-PA treatment. The most common mechanism of colistin involves...