A5053338950- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 epidemiological studies
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Protein purification and stability
- Transgenic Plants and Applications
- Immunotherapy and Immune Responses
Humboldt-Universität zu Berlin
2020-2025
Institute of Theoretical and Experimental Biophysics
2025
Universidad Nacional Autónoma de México
2021
Bacillus subtilis is a bacterial cell factory with outstanding protein secretion capabilities that has been deployed as workhorse for the production of industrial enzymes more than century. Nevertheless, other proteins B. subtilis, such antibody formats, thus far challenging due to specific requirements relate correct folding and disulfide bond formation upon export from cytoplasm. In present study, we explored possibility producing functional scFvs scFabs, using genome-reduced Midi-...
Abstract Reaching population immunity against COVID‐19 is proving difficult even in countries with high vaccination levels. Thus, it critical to identify limits of control and effective measures future outbreaks. The effects nonpharmaceutical interventions (NPIs) strategies are analyzed a detailed community‐specific agent‐based model (ABM). authors demonstrate that the threshold for not unique number, but depends on strategy. Prioritizing highly interactive people diminishes risk an...
Abstract Reaching population immunity against COVID-19 is proving difficult even in countries with high vaccination levels. We demonstrate that this part due to heterogeneity and stochasticity resulting from community-specific human-human interaction infection networks. address challenge by simulation of adaptive strategies. Analyzing the predicted effect into an ongoing outbreak, we find combinations targeted non-pharmaceutical interventions (NPIs) are required reach immunity. Importantly,...
Cell penetrating peptides (CPPs) are molecules capable of passing through biological membranes. This capacity has been used to deliver impermeable into cells, such as drugs and DNA probes, among others. However, the internalization these lacks specificity: CPPs internalize indistinctly on different cell types. Two major approaches have described address this problem: (i) targeting, in which a receptor-recognizing sequence is added CPP, (ii) activation, where non-active form CPP activated...