A5056480658- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Biosimilars and Bioanalytical Methods
- Retinal Development and Disorders
- Rheumatoid Arthritis Research and Therapies
- Economic and Financial Impacts of Cancer
- Monoclonal and Polyclonal Antibodies Research
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Liver Diseases and Immunity
- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- Clinical practice guidelines implementation
- Cellular transport and secretion
- CRISPR and Genetic Engineering
- Marine animal studies overview
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Lymphocytic Leukemia Research
- Folate and B Vitamins Research
- Phytoestrogen effects and research
Truven Health Analytics (United States)
2015-2024
fRI Research
2016
Cardinal Health (United States)
2012-2013
King's College London
1997-2007
Dana-Farber Cancer Institute
2003
Harvard University
2003
Leeds General Infirmary
2002
University of Alabama at Birmingham
1997
University of Notre Dame
1993-1997
Case Western Reserve University
1987
The Drosophila retinal degeneration B (rdgB) mutation causes abnormal photoreceptor response and light-enhanced degeneration. Immunoblots using polyclonal anti-rdgB serum showed that rdgB is a 160-kD membrane protein. antiserum localized the protein in photoreceptors, antennae, regions of brain, indicating functions many sensory neuronal cells. In adjacent to rhabdomeres, vicinity subrhabdomeric cisternae. protein's amino-terminal 281 residues are > 40% identical rat brain...
Abstract Background and aims Achieving sustained virological response (SVR; cure) in hepatitis C patients using a simple regimen is key to making elimination by 2030 possible. In the largest real‐world analysis date, effectiveness of pangenotypic, panfibrotic, single‐tablet, sofosbuvir/velpatasvir (SOF/VEL) once‐daily for 12 weeks was assessed clinical cohorts from various geographical areas, settings treatment practices. Factors affecting risk not achieving SVR were assessed. Methods Adults...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic worldwide, and its prevalence continues to rise. Fibrosis‐4 index (FIB‐4) has been shown be a prognostic marker of liver‐related outcomes in patients with NAFLD. We analyzed data from TriNetX global federated research network, combining on 30 million patients. Patients were categorized into three diagnostic groups: NAFLD, nonalcoholic steatohepatitis (NASH), at risk NASH. Primary outcome was all‐cause mortality, secondary...
Nonalcoholic fatty liver disease (NAFLD) is closely associated with an increased risk of cardiovascular disease. We aimed to determine whether the fibrosis-4 index (FIB-4) can identify patients NAFLD at highest events.We analyzed data from 81,108 (i) a diagnosis NAFLD, (ii) nonalcoholic steatohepatitis (NASH), or (iii) (RISK) NASH. The outcome interest was major adverse events (MACE) defined by myocardial infarction, hospitalization for unstable angina heart failure, and coronary...
The Drosophila retinal degeneration B (rdgB) gene encodes an integral membrane protein involved in phototransduction and prevention of degeneration. RdgB represents a nonclassical phosphatidylinositol transfer (PITP) as all other known PITPs are soluble polypeptides. Our data demonstrate roles for proper termination the light response dark recovery photoreceptor cells. Expression RdgB's PITP domain (RdgB-PITP) rdgB2 mutant flies is sufficient to completely restore wild-type...
Despite the clinical success in real-world of all oral hepatitis C virus (HCV) therapy with response rates approaching that seen trials, access has been limited by many payers discussion prioritization treatment based upon AASLD guidelines. We evaluated patients TRIO network who were prescribed sofosbuvir (SOF)-based regimens to determine reasons for not starting treatment. Trio Health is a disease management company works partnership academic medical centres, community physicians and...
In all eukaryotes, anaphase is triggered by the activation of a protease called separase. Once activated, separase cleaves subunit cohesin, complex that links replicated chromatids before anaphase. Separase and cohesin are conserved from yeasts to humans. Although machinery for dissolving sister cohesion conserved, regulation this process appears be more in higher eukaryotes than yeast. Here we report cloning full-length human cDNA characterization encoded protein. Human was observed at...
Abstract Background Atherosclerosis is potentiated by stimulation of Toll‐like receptors (TLRs), which serve to detect pathogen associated molecular patterns (PAMPs). However little known PAMPs may be present in atheroma, or capable stimulating inflammatory signalling vascular cells. Materials and Methods DNA extracted from human carotid atheroma samples was amplified sequenced using broad‐range 16S gene specific primers establish historical exposure bacterial PAMPs. Responsiveness primary...
Treatment of genotype 1 hepatitis C virus (HCV) infection with combination direct acting anti-virals is associated very high rates sustained virological response (SVR). Daily ledipasvir and sofosbuvir for 12 weeks approved the treatment HCV patients, though noncirrhotic patients who are naïve to a baseline RNA <6 million IU/mL can be treated 8 weeks. This guidance stemmed from post hoc analysis ION 3 clinical trial, which demonstrated similar SVR or without ribavirin weeks.To compare vs in...
Despite rising medical costs within the US healthcare system, quality and outcomes are not improving. Without significant policy reform, cost-quality imbalance will reach unsustainable proportions in foreseeable future. The cost of part results from an expanding aging population with increasing number life-threatening diseases. This is further compounded by a growing arsenal high-cost therapies. In no specialty this more apparent than area oncology. Numerous attempts to reduce have been...
Summary Background Elbasvir‐grazoprevir is indicated for chronic hepatitis C virus ( HCV ) genotypes 1 and 4. Aim To evaluate the utilization outcomes of patients treated with elbasvir‐grazoprevir in United States. Methods We conducted a retrospective cohort study adults or without ribavirin 4 infection. Data were collected from healthcare providers specialty pharmacies through Innervation Platform, proprietary, cloud‐based disease management program Trio Health. The primary endpoint was per...
Mutations in the Drosophila rdgB gene, which encodes a transmembrane phosphatidylinositol transfer protein (PITP), cause light-enhanced retinal degeneration. Cloning of mammalian orthologs ( mrdgB ) reveal predicted proteins that are 39% identical to , with highest homology N-terminal PITP domain (62%) and region near C terminus (65%). The human gene spans ∼12 kb maps 11q13.1, locus where several diseases have also been mapped. Murine syntenic on proximal chromosome 19. MrdgB is specifically...
Woodland caribou (Rangifer tarandus (Gmelin, 1788)) populations have declined throughout their range. With the goal of better understanding habitat selection and fidelity during neonatal calving period (0–4 weeks), we applied a noninvasive method that estimates events subsequent survival based on changes in movement rates among GPS-collared female caribou. We examined long-term GPS-collar data set (1998–2014) collected from 81 adult two central mountain herds Alberta British Columbia,...
The use of individual patient data (IPD) in network meta‐analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, NMAs are performed using aggregate for at least some, if all, the studies. We investigate benefits including varying proportions IPD an NMA. Several models have previously been developed both and same a simulation study based on these to examine impact additional accuracy precision estimates treatment effect covariate effect. also compared...
Pulmonary arterial hypertension (PAH) is a rare, life-limiting disease. PAH registries provide real-world data that complement clinical trial and inform treatment decisions. The TRIO comprehensive, integrated patient repository (TRIO CIPDR), an innovative US capturing on contemporary patients diagnosed with pulmonary receiving Food Drug Administration-approved therapies. This uniquely combines from electronic medical records the ability to track drug-prescription drug-dispensing...
Research describing patient experience and outcomes with extended half-life recombinant factor VIII (EHL rFVIII) outside of clinical trials is limited. Real-world rFVIII consumption studies, when people hemophilia A (PWHA) switch from standard (SHL) to EHL rFVIII, may help payers clinicians make more informed treatment choices.
Real-world data are limited on tenofovir alafenamide (TAF). We aimed to study TAF real-world outcomes with other first-line regimens for chronic hepatitis B (CHB). enrolled patients CHB from 10 centers retrospectively and followed them 36 months prospectively. analyzed switching patterns of antiviral therapy treatment TAF, disoproxil fumarate (TDF), entecavir therapy. For efficacy safety, we a subset complete at 24 after or remaining TDF entecavir. Among 1037 enrollees, 889 were analyzed....
Hepatitis C virus (HCV) is prevalent in people with mental health disorders, a priority population to diagnose and cure order achieve HCV elimination. This integrated analysis pooled data from 20 cohorts seven countries evaluate the real-world effectiveness of pangenotypic direct-acting antiviral (DAA) sofosbuvir/velpatasvir (SOF/VEL) disorders. HCV-infected patients diagnosed disorders who were treated SOF/VEL for 12 weeks without ribavirin as part routine clinical practice included. The...