Purpose: The antimicrobial activity of the 90 % ethanol extract aerial parts Sida acuta Burm. F. (Malvaceae) was investigated in other to verify its claimed ethno medicinal use treatment microbial infections. Method: tested against standard strains and clinical isolates some aerobic bacteria a fungus using Agar well diffusion method. Commercial antibiotics were used as positive reference standards determine sensitivity strains. Results: extracts showed significant inhibitory Staphylococcus...

In order to assess patterns of antibiotic prescribing and self-medication, a survey was carried out patients from Government private hospitals (500 each) 1000 apparently healthy adults in Benin City, Nigeria. Ampicillin tetracycline were the antibiotics commonly used for self-medication; commonest reasons given self-medication treatment sexually transmitted diseases, cough, stomach upsets diarrhoea. prescribed antibiotic; indications prescription soft-tissue, transmitted, upper respiratory...

The prevalence of asymptomatic genital infection among pregnant women and their susceptibility to antibacterial agents was investigated provide baseline data on common microorganisms identify potentials for development clinical disease this cohort patients. High vaginal swabs were obtained from five hundred consecutive consenting attending the antenatal clinic University Benin Teaching Hospital (UBTH) Central Hospital, both in City, Nigeria. A total three specimens showed significant...

While numerous studies examine the epidemiology and molecular characterization of Staphylococcus aureus in most developed countries, detailed S. strains clones Africa is lacking. We determined virulence 81 non-duplicate isolates from Benin-City, Nigeria, collected during January–July 2016, compared with global strains. Forty-seven (58.0%) were found to be methicillin-sensitive (MSSA), while 34 (42.0%) methicillin-resistant (MRSA). ST152-MSSA (24.7%) ST7-MRSA-V (19.8%) dominant groups...

Purpose: A research was carried out to investigate the incidence of microflora in tablets dispensed from large container packages used hospitals and community pharmacies. It designed provide base-line data on common biodegrading microorganisms associated with retail containers highlight health implications such observations roles for pharmacists self medication phenomenon Nigeria. Methods: The protocol study involved structured selection representative named some public pharmacies within...

Following recent concern over probable interactions between the 4-quinolones and metal ions, effect of co-administered drugs—sodium bicarbonate, potassium citrate, ferrous sulphate, magnesium tnsilicate, calcium carbonate aluminium hydroxide—on saliva urine pharmacokinetics ofloxacin in healthy human volunteers has been investigated. The Cmax AUC0–9 were generally range 1.05–1.40 mg/L 4.89–6.16 mg.h/L, respectively, unaffected (P < 0.05) by metallic drugs, except hydroxide which lowered...

Purpose: To determine the antimicrobial activity and chemical constituents of ethyl acetate extract Citrullus lanatus seeds.Methods: Antimicrobial seeds C. was evaluated against Staphylococus aureus ATCC 25923, Escherichia coli 25922, Bacillus subtilis NCTC8236, Pseudomonas aeruginosa 10145 Candida albicans 24433 using standard microbiological method. Chemical were determined with Gas chromatography mass spectrometry (GC MS) systems.Results: An oily, yellowish orange coloured a yield 18.7 %...

Ofloxacin pharmacokinetics have been studied in four healthy subjects after a single oral or rectal dose, each of 200 mg. For the dose tmax was about 2 h, Cmax 1·96±0·56 μg/ml and AUC1–15 15·22 μg/ml.h. Two-phase elimination pharmacol kinetics were observed for t1/2 rapid phase 3·3 h slow 10 h. With 6 0·71±0·44 AUC0–15 7·58 The relative bioavailability (AUC rectal/AUC oral) 49·8%.%Elimination rate generally (t1/2=9 h), an observation attributable to sustained-release effect suppository base,...

A pharmaceutical excipient is required to meet certain minimum standards for use in the manufacture of dosage forms. In this study, two such requirements, microbiological and toxicological suitability, was investigated respect cellulose powder derived from an agricultural waste, maize cob. Microbial count data were obtained by inoculating a suspension into various types agar. We also studied some possible effects sub-acute ingestion 2% tragacanth mucilage on adult male Wistar rats given 1.6...

Purpose: This study aims to establish the safety and/or potential public health dangers associated with consumption of liquid herbal preparations (LHP) sold in Ilorin-Kwara State. Methods: Ten LHPs were randomly collected from three locations, kept under cold chain and transported Laboratory. All samples evaluated for bacterial load using aerobic plate count method isolates presumptively identified standard microbiological methods. Furthermore, Gram negative bacteria 12A Microbact ®...

Non-steroidal anti-inflammatory drugs (NSAIDs) are often co-administered with antibiotics such as Ciprofloxacin, a second generation fluoroquinolone, in situations which Staphylococcus aureus infections accompanied pain and inflammation. The contra- indications have not been found to attract deliberate study. This study was therefore investigate possible interactions co -administration of ciprofloxacin some NSAIDs. vivo effect co-administration the NSAIDs (acetyl salicylic acid (ASA),...

The volatile oil of Murraya keonigii was active against Staphylococcus epidemidis, S. aureus, and Streptococcus specie while the aqueous extract not Key Words: koenigii, Rutaceae, antibacterial activity Nig. J. Nat. Prod. And Med. Vol.2 1998: 44-45

Association of odontogenic infections with several systemic diseases is public health importance in Nigeria. This study aimed at determining the epidemiological and microbiological profiles it aetiologic agents dental patients Benin City metropolis. Surface deep socket swabs were collected from each patient before after tooth extraction processed for aerobic bacteria. Antimicrobial susceptibility test was carried out on isolate using standard methods. Demographics data recording format....

In order that appropriate clinical interpretation of microflora and drug management root canal infections would be achieved, the fungi contents following biomechanical instrumentation were determined. Mucor, yeast, candida, microsporium fusarium species recovered at different stages instrumentation. The presence could complicate treatments. possible implications these findings in treatment failures are highlighted.