A5077692699- Ubiquitin and proteasome pathways
- Nonmelanoma Skin Cancer Studies
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Protein Degradation and Inhibitors
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Cutaneous lymphoproliferative disorders research
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Melanoma and MAPK Pathways
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Protease and Inhibitor Mechanisms
- Coconut Research and Applications
- Cellular Mechanics and Interactions
- Skin and Cellular Biology Research
- Skin Protection and Aging
- Plant Virus Research Studies
- Genomics and Chromatin Dynamics
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Biotin and Related Studies
- RNA modifications and cancer
Stanford University
2019-2025
University of Washington
2023-2024
Fred Hutch Cancer Center
2024
Translational Genomics Research Institute
2018
Collagens are the most abundant proteins in body and comprise basement membranes stroma through which cancerous invasion occurs; however, a pro-neoplastic function for mutant collagens is undefined. Here we identify COL11A1 mutations 66 of 100 cutaneous squamous cell carcinomas (cSCCs), second common U.S. cancer, concentrated triple helical region known to produce trans-dominant collagens. Analysis other collagen genes found that they mutated across epithelial malignancies. Knockout impairs...
The human skin is a complex organ that forms the first line of defense against pathogens and external injury. It composed wide variety cells work together to maintain homeostasis prevent disease, such as cancer. exponentially rising incidence malignancies poses growing public health challenge, particularly when disease course complicated by metastasis therapeutic resistance. Recent advances in single-cell transcriptomics have provided high-resolution view gene expression heterogeneity can be...
Abstract Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We performed a transcriptome-wide screen for genes of unknown function that possess inverse expression patterns differentiating keratinocytes compared with cutaneous SCC (cSCC), leading to identification MAB21L4 (C2ORF54) as an enforcer differentiation suppresses...
Abstract Extrachromosomal DNA (ecDNA) is a mechanism of oncogene amplification that occurs in many cancers and has been linked to worse patient outcomes. While ecDNA previously identified cutaneous melanoma, it yet be described squamous cell carcinoma (cSCC). Using whole genome sequencing transcriptomic data primary metastatic cSCC tumors, we establish the presence confirm elevated expression ecDNA-associated genes. We also find correlates with higher lymph node ratio, measure disease...
Abstract Background Cutaneous squamous cell carcinomas (SCC) are the second most common human cancer and have been characterized by RNA sequencing (RNA-Seq); however, transferability of findings from individual studies may be limited small sample sizes diverse analysis protocols. Objectives To define transcriptome landscape at different stages in progression normal skin to SCC through a meta-analysis publicly available RNA-Seq samples Methods Whole-transcriptome data 73 samples, 46 actinic...
Abstract OBJECTIVE Glioblastoma (GBM) is the most common malignant primary brain tumor in adults, with males more commonly affected than females(1.6:1). Despite advancements treatments, prognosis dismal a median overall survival of 15 months. Our aim was to investigate sex as variable GBM patient after receiving incremental levels standard-of-care treatment regimens – different extents surgical resection and numbers cycles adjuvant temozolomide chemotherapy. METHODS Drawing from our...
<div>Abstract<p>Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We performed a transcriptome-wide screen for genes of unknown function that possess inverse expression patterns differentiating keratinocytes compared with cutaneous SCC (cSCC), leading to identification <i>MAB21L4</i>...
Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
Supplementary Data from MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET
<div>Abstract<p>Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We performed a transcriptome-wide screen for genes of unknown function that possess inverse expression patterns differentiating keratinocytes compared with cutaneous SCC (cSCC), leading to identification <i>MAB21L4</i>...
EDDY (Evaluation of Differential DependencY) interrogates transcriptomic data to identify differential genetic dependencies within a biological pathway. Through its probabilistic framework with resampling and permutation, aided by the incorporation annotated gene sets, demonstrated superior sensitivity other methods. However, this statistical rigor incurs considerable computational cost, limiting application larger datasets. The ample independent computation coupled manageable memory...
Abstract Epithelial squamous cell carcinomas (SCC) most commonly originate in the skin, where they display disruptions normally tightly regulated homeostatic balance between keratinocyte proliferation and terminal differentiation. We performed a transcriptome-wide screen for genes of unknown function that possess inverse expression patterns differentiating keratinocytes compared to cutaneous SCC (cSCC) identified MAB21L4 ( C2ORF54 ) as an enforcer differentiation suppresses carcinogenesis....