A5105512428- Mechanical Circulatory Support Devices
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Synthetic Organic Chemistry Methods
- Cardiac Structural Anomalies and Repair
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Orthopaedic implants and arthroplasty
- Cardiac pacing and defibrillation studies
- Catalytic C–H Functionalization Methods
- Cardiac Imaging and Diagnostics
- Total Knee Arthroplasty Outcomes
- Transplantation: Methods and Outcomes
- Rice Cultivation and Yield Improvement
- Congenital Heart Disease Studies
- Synthesis and Catalytic Reactions
- Orthopedic Infections and Treatments
- Cardiac Arrest and Resuscitation
- Histone Deacetylase Inhibitors Research
- Synthesis and biological activity
- Osteoarthritis Treatment and Mechanisms
- Synthesis and Biological Evaluation
Central Drug Research Institute
2010-2025
Academy of Scientific and Innovative Research
2015-2025
Scripps Clinic
2015-2024
La Jolla Alcohol Research
2023
Geological Survey of India
2017-2023
McLaren Regional Medical Center
2010-2023
SimBiotic Software (United States)
2023
Altoona Arthritis and Osteoporosis Center
2023
American Academy of Orthopaedic Surgeons
2023
Hurley Medical Center
2023
Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for treatment hypertension several decades. Selective inhibition is essential but difficult to achieve because cortisol catalyzed by another enzyme that shares 93% sequence similarity with synthase. In preclinical phase 1 studies, baxdrostat had 100:1 selectivity inhibition, at dose levels reduced plasma not levels.In this multicenter, placebo-controlled trial, we randomly assigned patients who...
Left ventricular outflow tract velocity time integral (LVOT VTI) is a measure of cardiac systolic function and output. Heart failure patients with low output are known to have poor cardiovascular outcomes. Thus, extremely LVOT VTI may predict heart at highest risk for mortality. Patients were identified from single-center database. Baseline characteristics related clinical outcomes (death, LVAD) obtained 12 months. Correlation between endpoints the following variables analyzed: ejection...
A one-pot process has been developed for preparing alkaloid-like tricyclic skeletons by employing an Ugi reaction, acid mediated ipso-cyclization and aza-Michael addition. The transformation is operationally simple provides products in a diastereo- regioselective manner with good-to-excellent yields.
A photocatalytic method has been developed for the efficient synthesis of functionalized benzimidazoles. This protocol involves condensation o-phenylenediamines with various aldehydes using Rose Bengal as photocatalyst. The was found to be general and successfully employed accessing pharmaceutically important benzimidazoles by aromatic, heteroaromatic aliphatic o-phenylenediamines, in good-to-excellent yields. Notably, effective less reactive heterocyclic o-phenylenediamines.
This study aimed to evaluate the long-term prognostic value of serial assessment coronary flow reserve (CFR) by rubidium Rb 82 (
Herein, we describe an efficient and operationally simple methodology for the synthesis of imidazo[1,2-a]quinoxalin-4(5H)-ones via a molecular iodine-mediated annulation quinoxalin-2(1H)-ones oxime acetates in [3+2] fashion. This reaction offers novel straight forward method constructing functionalized highly regioselective manner.
A solution-phase parallel synthesis of pharmaceutically important azaspiro[4.5]trienones has been developed by performing tandem Ugi four-component condensation (U4CC), involving substituted p-anisidines, aldehydes, 3-alkyl/aryl-propiolic acids, and isocyanides, iodine-mediated ipso-iodocyclization in one-pot. This highly atom economical process produced functionalized good to excellent overall yields products were easily isolated precipitation followed crystallization. These vinyl-iodide...
A series of ethanolamine‐derived Ugi four‐component‐reaction adducts were subjected to a base‐mediated cycloisomerization/rearrangement cascade give functionalized 2,5‐pyrrolidinediones in good‐to‐excellent yields. The method was extended amino‐acid‐derived chiral ethanolamines access enantiomerically pure 2,5‐pyrrolidinediones. reaction is diastereospecific, and mixtures β‐lactams formed with high enantiomeric excess. Mechanistic studies revealed that the proceeds through formation β‐lactam...
We report a new method to create enantioenriched azatricycles using chiral α-amino acids in two-step process after an Ugi reaction. Amino are great building blocks for making pure molecules. Using natural molecules multicomponent reactions (MCRs) helps increase their variety by adding centers. The reaction, discovered Ivar Karl 1959, is versatile MCR that complex molecular structures and products through additional transformations called post-Ugi modifications. Designing these modifications...
Abstract Introduction Atrial fibrillation affects an estimated 2.5 million Americans and incurs average annual stroke risk of 4.5% per year. Despite warfarin reducing by approximately 66%, prior studies show usage rates to be about 50%. However, the methods that define as "inappropriate underutilization" might not sensitive enough pick up relative contraindications. We assessed inappropriate underutilization in atrial patients at our hospital abstracting individual patient charts. Methods...