A5040038994- Synthetic Organic Chemistry Methods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Bacteriophages and microbial interactions
- Marine Sponges and Natural Products
- Biosensors and Analytical Detection
- Synthesis and Characterization of Pyrroles
- Microbial Natural Products and Biosynthesis
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Advanced Synthetic Organic Chemistry
- Metal-Catalyzed Oxygenation Mechanisms
Central Drug Research Institute
2019-2024
Academy of Scientific and Innovative Research
2019-2024
University of Lucknow
2019
NOAA Chemical Sciences Laboratory
2019
National Chemical Laboratory
2017
The use of a peroxidase-mimicking Fe complex has been reported on the basis biuret-modified TAML macrocyclic ligand framework (Fe-bTAML) as catalyst to perform selective oxidation unactivated 3° C-H bonds and activated 2° with low loading (1 mol %) high product yield (excellent mass balance) under near-neutral conditions broad substrate scope (18 substrates which includes arenes, heteroaromatics, polar functional groups). Aliphatic sites was achieved predictable selectivity using steric,...
We report a new method to create enantioenriched azatricycles using chiral α-amino acids in two-step process after an Ugi reaction. Amino are great building blocks for making pure molecules. Using natural molecules multicomponent reactions (MCRs) helps increase their variety by adding centers. The reaction, discovered Ivar Karl 1959, is versatile MCR that complex molecular structures and products through additional transformations called post-Ugi modifications. Designing these modifications...
An efficient method for synthesizing C(1)-carboxamides through IBX-mediated oxidative addition of isocyanides to cyclic secondary amines has been reported.
A novel method for the generation of uniquely functionalized piperazinones by utilizing post-Ugi functionalization is described. The involves an Ugi reaction with aminoacetaldehyde dimethyl acetal, followed acid-mediated cyclization to generate iminium precursor that was subjected nucleophilic addition in a diastereoselective manner. also employed synthesize trans-dragmacidine C and praziquantel-like molecules.
The present study provides an insight into the reactivity of Passerini and Ugi adducts in basic medium leading to α-ketoamides.
Abstract Post‐Ugi modifications offer a great tool to construct functionalized heterocycles in an atom‐economic manner. Using this approach, we have constructed highly azaspiro tricyclic scaffolds that involve Ugi condensation and ipso ‐cyclization followed by aza‐Michael ring closures. Herein, present detailed account of cyclizations with respect substrate scope limitations, along new methods prepare novel scaffolds.
Abstract Advances in base‐mediated post‐Ugi transformations are reported and discussed. The minireview encompasses reports showing the abstraction of an alpha proton adjacent to amide carbonyl aldehyde‐derived Ugi adducts under basic conditions perform intramolecular intermolecular cyclizations. methodologies have been broadly classified depending on peptidyl anion trapping metal‐free, metal‐catalyzed, microwave‐assisted, external electrophile‐aided reaction conditions. A comprehensive...
Pseudomonas aeruginosa (P. aeruginosa) infection is becoming a severe health hazard and needs early diagnosis with high specificity. However, the non-specific binding of biosensor challenge to current bacterial detection system. For first time, we chemically synthesized galactose tripod (GT) as P. aeruginosa-specific ligand. We conjugated GT photothermally active fluorescent nanocomposite (Au@SiO2-TCPP). can be detected using Au@SiO2-TCPP-GT, additionally ablated well synergistic...
Stereoselective difunctionalizations of the terminal and internal alkynes with various sulfinates isocyanides have been achieved to prepare (Z)-/(E)-β-sulfonylacrylamides. The (Z)-β-sulfonylacrylamides were generated via a one-pot process that involves reaction in presence iodine sequential manner. (E)-β-sulfonylacrylamides prepared two-step synthesis palladium(II)-catalyzed addition isocyanide (E)-β-iodovinylsulfones synthesized from alkynes.
An efficient strategy for the synthesis of unexplored 8‐quinolinesulfinate esters has been reported. The method involves in situ generation quinoline sulfinate from N' ‐acetylquinoline‐8‐sulfonohydrazide via silver mediated cleavage followed by palladium‐catalyzed cross‐coupling with 1° and 2° alcohols to yield esters. A variety substituted were successfully employed reaction. Control experiments performed understand mechanism, revealed that transformation follows a radical pathway alcohol...
Catalyst-free hydroamination and hydrothiolation of vinyl heteroarenes/electron deficient alkenes have been achieved in an aqueous medium.
The Cover Feature depicts a gradual process for synthesizing complex azaspiro tricyclic scaffolds starting from common building blocks through substrate-selective post-Ugi modifications that involve spirocyclization and aza-Michael addition, which is depicted by analogy with tree. materials are illustrated as the soil nutrients taken up roots to generate Ugi adducts. cover picture was designed Mr. Kazim, Mayur D. Ambule, Mandweep Bhumij, Dr. Ajay Kumar Srivastava. More information can be...