A5038641053- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and genetic disorders
- Cardiovascular and Diving-Related Complications
- Vestibular and auditory disorders
- Infective Endocarditis Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Stroke Rehabilitation and Recovery
- Circadian rhythm and melatonin
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Ophthalmology and Eye Disorders
- S100 Proteins and Annexins
- Migraine and Headache Studies
- Advanced Neuroimaging Techniques and Applications
- Biochemical effects in animals
- Neurological Complications and Syndromes
- Alzheimer's disease research and treatments
- Cardiac Arrhythmias and Treatments
Perm State Medical Academy
2016-2025
City Clinical Hospital
2018-2025
Ministry of Health of the Russian Federation
2017-2024
Perm State University
2016
Moscow Architectural Institute
2013
Transient global amnesia (TGA) is a benign, stress-induced neurological syndrome associated with reversible hippocampal dysfunction that manifests as isolated, predominantly anterograde amnesia. Since it impossible to make definitive diagnosis of TGA when the patient admitted hospital, primary condition should be interpreted an acute cerebrovascular accident, which implies mandatory neuroimaging examination and clarification question thrombolysis according general principles. When taking...
The paper presents experts' opinion on the clinical manifestations and diagnosis of chronic cerebrovascular disease (CVD) (chronic cerebral ischemia (CCI) dyscirculatory encephalopathy (DEP)) at pre-dementia stage. It is noted that DEP/CCI a common in Russian neurological practice, criteria for which have not been updated long time. most often develops presence small artery (CSA) (cerebral microangiopathy (CMA)), severity can be quantified by magnetic resonance imaging. main manifestation...
Thrombolytic therapy (TLT) of ischemic stroke (IS) with alteplase within the first 4.5 hours from onset symptoms is most effective and proven method treatment. Objective: to evaluate safety efficacy TLT Revelisa (alteplase) in IS real-world clinical practice. Material methods. The results were analyzed 1181 patients IS: 616 (52.2%) women 565 (47.8%) men (mean age 68.28±12.56 years), which 140 (11.9%) staged reperfusion. mean time disease was 2.58±0.83 hours. Heidelberg classification used...
The article presents three clinical cases of patients with migraine aura and long-term focal symptoms without the formation ischemic foci. A case migraine-associated stroke is presented for comparison. indicate that admission to hospital a patient history neurological deficit challenging situation requires individualization diagnostic therapeutic tactics. In presence prolonged aura, CT perfusion, diffusion-weighted magnetic resonance imaging, can contribute an informed decision. MRI findings...
To compare the effectiveness and safety of use non-immunogenic staphylokinase (NS) alteplase (AP) for intravenous thrombolysis (IT) ischemic stroke (IS) in real clinical practice at a regional vascular center.
The epidemiology of vestibular migraine (VM), which is the most common cause episodic dizziness, discussed. pathogenesis schematic discussed, key feature disturbance interaction trigemino-vascular system, nociceptive centers brain stem, thalamocortical networks and system. clinical picture disease presented in form spontaneous, positional, visually induced head movement-induced cochlear other symptoms. relation symptoms headache was analyzed. data neurological examination are reflected,...
The paper considers the relevance of problem cerebral small vessel disease (CSVD) that is an important cause ischemic and hemorrhagic stroke, associated with development cognitive impairment complications antithrombotic therapy. It presents briefly current issues etiology pathogenesis disease. Sporadic non-amyloid microangiopathy, amyloid angiopathy, autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy (CADASIL) are discussed in detail from point view their clinical...
The article discusses two main causes of acute vestibular dizziness - vertebrobasilar ischemic stroke and neuritis. features syndrome depending on the localization cerebral infarction in territory posterior inferior, anterior inferior superior cerebellar arteries, as well brain stem are presented. Detailed clinical characteristics neuritis is given. issues differential diagnosis diseases, including nystagmus head impulse test, discussed. approaches to treatment its etiology considered....
The review deals with approaches to the differential diagnosis of causes vertigo in emergency neurology. main episodic and acute vestibular syndrome are discussed. Clinical diagnostic methods for (evaluation nystagmus, test skew, head-impulse neurological status) considered. signs “benign” symptoms indicating a stroke vertebrobasilar system presented. Differential criteria peripheral central disorders Transient ischemic attacks, features otoneurologic status neuronitis different...
Non-cardioembolic ischemic stroke (IS) of high and very risk includes three groups patients: with severe extracranial atherosclerosis, any intracranial aortic arch atheromatosis. This is also characteristic patients aggressive transient attack (TIA) phenotypes. Effectiveness secondary prophylaxis can be raised by these strategies: short-term dual antiplatelet therapy using a combination acetylsalicylic acid clopidogrel or ticagrelor in minor IS high-risk TIA; long-term antithrombotic low...
To present neuropsychological characteristics of post-stroke cognitive impairment (PSCI) in acute ischemic stroke (IS) and to assess the efficacy drug cellex.A comprehensive testing battery was administered 288 patients with IS. In addition basic therapy, 30 received cellexin dosage 0.1 mg (1 ml) subcutaneously for 10 days, treatment started phase.Multifunctional PSCI were revealed 87% Impairments attention, regulatory functions, speech memory identified majority patients. More than a third...
The paper considers the concept of vascular cognitive impairment (CI), no dementia, their epidemiology, risk markers and pathological basis. It describes in detail neuropsychological characteristics CI, relevant diagnostic criteria, clinical neuroimaging techniques. In addition to stroke, cerebral small vessel disease, which is characterized article a modern light, shown play an important role development moderate CI. course, prognosis impairment, determinants are discussed. Approaches...
The paper considers the epidemiology and general etiological characteristics of cryptogenic stroke (CS). It discusses concept embolic with an unknown source embolism. also characterizes most significant causes CS, such as paroxysmal atrial fibrillation, cardiopathy, aortic atheroma, non-stenotic cerebral atherosclerotic plaques, malignant neoplasms. describes approaches to diagnosis secondary prevention CS proposes neuroimaging diagnostic algorithms for CI. Clinical cases are presented.
Transient ischemic attack (TIA) in the vertebrobasilar vascular territory (VB) causes difficulties diagnosis when it manifests only with vestibular symptoms. Issues relating to differential of TIA are discussed, awareness which is necessary for selection informative methods examination and prescription effective stroke prevention patients an episode isolated dizziness. The likelihood as cause dizziness increased by patients' high cardiovascular risk, presence atrial fibrillation, severe...
Wernicke encephalopathy is a thiamine deficiency condition that has wide range of somatic causes in addition to alcohol abuse. Most patients do not have the classical clinical triad — oculomotor dysfunction, ataxia and cognitive impairment at onset disease, which makes timely diagnosis difficult. The disease may manifest as dizziness, unsteadiness, double vision, or impairment. Key manifestations include symmetrical gaze-evoked nystagmus, truncal ataxia, bilateral abducens paresis,...
In 1.4–6.5% of patients admitted to the emergency department with suspected stroke, another condition is diagnosed (stroke mimicker, SM). Type neurological event or SM) determines further patient management, both in terms diagnostics and treatment. An error leads a delay treatment underlying disease – epilepsy, Wernicke's encephalopathy, etc. At same time, differential diagnosis remains primarily clinical task, facilitated some extent by instrumental research methods. This article presents...
The paper characterizes the neuropathological aspects of cerebral amyloid angiopathy (CAA) and its pathogenesis. It presents in detail current neuroimaging markers CAA their correlates. phenotypic heterogeneity disease main clinical manifestations are considered; updated Boston diagnostic criteria formulated. issues intracerebral hemorrhages, microbleeding, cortical superficial siderosis, which associated with CAA, elucidated detail. is noted to be significance for determination therapeutic...
Post-stroke cognitive impairment is a clinically heterogeneous condition, some types of which cannot be fully differentiated neuropsychologically that necessitates the active search for biomarkers.Analyze parameters neuroinflammation and neurodegeneration in combination with neuroimaging markers patients different post-stroke acute ischemic stroke.In 72 we performed assessment status distinguished 3 types: normal cognition, dysexecutive, mixed impairment. In each group determined...
Inflammation is probably the main process that links cardiovascular risk factors with damage to blood vessels and neurons. Elucidation of mechanisms this relationship an important issue.70 acute stroke patients were studied assess their neuropsychological (MMSE, MoCA, FAB, Clock Drawing Test, Shulte Tables Verbal Fluency) functional status (mRS, Rivermead Mobility Index). The serum liquor IL-1β, IL-6, TNFa IL-10 levels analyzed. Control group included subjects without cerebrovascular...
In young patients, the causes of ischemic stroke (IS) are substantially different from those in older patients. Understanding disease patients younger than 45 years is needed to elaborate examination algorithms used country’s vascular departments. Objective : present nosological characteristics IS according hospital register regional center. Patients and methods . The data neurological unit for with acute cerebral circulatory disorders, who were Perm Territorial Vascular Center, City...
The article discusses the concept of embolic stroke from an unspecified source and role aorto-arterial embolism in its development. Potential causes cryptogenic such as aortic atheromatosis, non-stenotic atherosclerosis cervical arteries, carotid web intracranial are discussed detail. discussion each cause covers epidemiology, pathogenesis, current approaches to diagnosis secondary prevention. diagnostic search is presented form algorithm. To identify sources determine their clinical...
In the International Classification of Diseases 11th revision in section «Diseases nervous system», it is proposed to distinguish «Cerebrovascular disorder with neurocognitive impairment», which corresponds both discirculatory encephalopathy (DEP) or chronic cerebral ischemia (CCI) accepted our country, and also vascular cognitive impairments. The terminology, prevalence, risk factors pathological basis disease are discussed, particular multiple infarctions, strategic small vessel disease,...
Cryptogenic stroke (CS) is defined as a subtype of associated with heterogeneous group pathogenetic mechanisms that remained undetermined in the course advanced diagnostic research. One third or fourth ischemic strokes cryptogenic. Paradoxical embolism considered important cause cryptogenic and transient ischaemic attack (TIA) young patients. It may occur via following: patent foramen ovale (PFO), atrial septal defect (ASD), pulmonary arteriovenous malformation (PAVM). When interviewing...