A5010141473- Chronic Lymphocytic Leukemia Research
- Metabolism, Diabetes, and Cancer
- Acute Lymphoblastic Leukemia research
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Amino Acid Enzymes and Metabolism
- Plant and Fungal Interactions Research
- Glycosylation and Glycoproteins Research
- Plant Virus Research Studies
- Glycogen Storage Diseases and Myoclonus
- Pancreatic and Hepatic Oncology Research
- Bacteriophages and microbial interactions
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
Cancer Center Amsterdam
2022-2024
University of Amsterdam
2019-2024
Amsterdam University Medical Centers
2019-2024
Oncode Institute
2022-2024
Lymphoma Research Foundation
2023
Chinese Academy of Sciences
2015
CD40 signaling upregulates BCL-XL and MCL-1 expression in the chronic lymphocytic leukemia (CLL) lymph node microenvironment (TME), affording resistance to BCL-2 inhibitor venetoclax (VEN). VEN therapeutic setting after long-term laboratory selection has been linked metabolic alterations, but underlying mechanism(s) are unknown. We aimed here discover how stimulation as a model for TME-mediated changes, affects sensitivity/resistance. increased oxidative phosphorylation (OXPHOS) glycolysis,...
The tumor suppressor p53 has been described to control various aspects of metabolic reprogramming in solid tumors, but B cell malignancies that role is as yet unknown. We generated pairs functional and knockout (KO) clones from distinct (acute lymphoblastic leukemia, chronic lymphocytic diffuse large lymphoma, multiple myeloma). Metabolomics isotope tracing showed loss did not drive a common signature. Instead, lines segregated according origin. Next, we focused on glutamine crucial energy...