A5086781261- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Tumors and Oncological Cases
- Chronic Lymphocytic Leukemia Research
- Prenatal Screening and Diagnostics
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Synthesis and biological activity
- Cancer-related Molecular Pathways
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Antibiotics Pharmacokinetics and Efficacy
- Computational Drug Discovery Methods
- Mesoporous Materials and Catalysis
- Milk Quality and Mastitis in Dairy Cows
- Lysosomal Storage Disorders Research
- CAR-T cell therapy research
- Amino Acid Enzymes and Metabolism
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Potato Plant Research
- Circular RNAs in diseases
- Carbohydrate Chemistry and Synthesis
Toscana Life Sciences
2023-2024
University of Siena
2018-2022
University of Campania "Luigi Vanvitelli"
2019-2021
University of Naples Federico II
2016
University of Bari Aldo Moro
2006
Abstract Background PADI6 is a component of the subcortical maternal complex, group proteins that abundantly expressed in oocyte cytoplasm, but required for correct development early embryo. Maternal-effect variants complex are associated with heterogeneous diseases, including female infertility, hydatidiform mole, and imprinting disorders multi-locus disturbance. While involvement infertility well demonstrated, its role less established. Results We have identified by whole-exome sequencing...
Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and lack new antibiotics is becoming global emergency. Therefore, research in antibacterial fields urgently needed expand currently available arsenal drugs. We have recently reported an alkyl-guanidine derivative (2), characterized by symmetrical dimeric structure, as good candidate for further developments, with high activity against both Gram-positive Gram-negative strains. In...
Personalized therapies are required for Fabry disease due to its large phenotypic spectrum and numerous different genotypes. In principle, missense mutations that do not affect the active site could be rescued with pharmacological chaperones. At present chaperones bind couple a stabilizing effect, which is required, an inhibitory deleterious. By in silico docking we identified allosteric hot-spot ligand binding where drug-like compound, 2,6-dithiopurine, binds preferentially....
Abstract Background A subset of individuals affected by imprinting disorders displays multi-locus disturbances (MLID). MLID has been associated with maternal-effect variants that alter the maintenance methylation at germline-derived differentially methylated regions (gDMRs) in early embryogenesis. Pedigrees also include siblings healthy phenotype. However, it is unknown if these have themselves or their patterns differ from those disorders, and general, affects clinical Methods We...
Abstract The reciprocal parent of origin-specific expression H19 and IGF2 is controlled by the H19/IGF2:IG-DMR (IC1), whose maternal allele unmethylated acts as a CTCF-dependent insulator. In humans, internal IC1 deletions are associated with Beckwith–Wiedemann syndrome (BWS) Silver-Russell (SRS), depending on their parental origin. These genetic mutations result in aberrant DNA methylation, deregulation IGF2/H19 disease incomplete penetrance. However, mechanism linking microdeletions to...
Antibiotic resistance is an increasingly important global public health issue, as major opportunistic pathogens are evolving toward multidrug- and pan-drug phenotypes. New antibiotics thus needed to maintain our ability treat bacterial infections. According the WHO, carbapenem-resistant Acinetobacter, Enterobactericaeae, Pseudomonas most critical targets for development of new antibacterial drugs. An automated phenotypic screen was implemented 634 synthetic compounds obtained in-house both...
The diffusion of antibiotic-resistant, Gram-negative, opportunistic pathogens, an increasingly important global public health issue, causes a significant socioeconomic burden. Acinetobacter baumannii isolates, despite causing lower number infections than Enterobacterales, often show multidrug-resistant phenotypes. Carbapenem resistance is also rather common, prompting the WHO to include carbapenem-resistant A. as "critical priority" for discovery and development new antibacterial agents. In...
Glucose catabolism, one of the essential pathways sustaining cellular bioenergetics, has been widely studied in context tumors. Nevertheless, function various branches glucose metabolism that stem from 'classical' glycolysis have only partially explored. This review focuses on discussing general mechanisms and pathological implications its branching biology B cell malignancies. We summarize here what is known regarding pentose phosphate, hexosamine, serine biosynthesis, glycogen synthesis...
Unraveling vulnerabilities in chronic lymphocytic leukemia (CLL) represents a key approach to understand molecular basis for its indolence and path toward developing tailored therapeutic approaches. In this study, we found that CLL cells are particularly sensitive the inhibitory action of abundant serum protein, apolipoprotein E (ApoE). Physiological concentrations ApoE affect cell viability inhibit CD40-driven proliferation. Transcriptomics ApoE-treated revealed signature redox metal...
Background: Unraveling intrinsic vulnerabilities in chronic lymphocytic leukemia (CLL) represents a key approach to understand molecular basis for its indolence and path towards designing tailored therapeutic approaches. We previously described that CLL cells are characterized by an ectopic expression of the immunomodulatory cell surface receptor ILT3/LILRB4 (Zurli et al. Blood 2017). Despite functional implications ILT3 have not been fully elucidated, selective presence on B cells, but...
litativo è privo di significato clinico, anche perché per lo più, i ceppi residenti nel normale non producono enterotossine.Riportiamo dati preliminari confronto fra isolamento quantitativo e ricerca dell'enterotossina fecale specifica.Metodi.La conta sporale quantitativa stata eseguita su 85 campioni (da 77 pazienti) con la metodica standard dopo shock etanolico.Per fecale, aliquote sono state sospese in salina, centrifugate ad alta velocità, ed il sopranatante usato saggio citotossicità,...