A5036048481- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Chemokine receptors and signaling
- S100 Proteins and Annexins
- Mast cells and histamine
- Food Allergy and Anaphylaxis Research
- Cell Adhesion Molecules Research
- Neonatal Respiratory Health Research
- Eosinophilic Disorders and Syndromes
- Pediatric health and respiratory diseases
- Membrane-based Ion Separation Techniques
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Plant chemical constituents analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Effects of Natural Compounds
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Autophagy in Disease and Therapy
- Nephrotoxicity and Medicinal Plants
- Ophthalmology and Eye Disorders
- Entomological Studies and Ecology
- Herbal Medicine Research Studies
Eulji University
2015-2024
Chungnam National University
2017
Korea Forest Service
2013
Yonsei University
2005-2010
University of Ulsan
2002-2004
Ulsan College
2002-2004
House dust mites (HDMs) induce allergic diseases such as asthma. Neutrophil apoptosis is an important process of innate immunity, and its dysregulation associated with In this study, we examined the effects HDM on constitutive normal asthmatic neutrophils. Extract Dermatophagoides pteronissinus (DP) inhibited neutrophil apoptosis, but farinae extract had no effect. Anti-apoptotic signaling mediated by DP involves in TLR4, Lyn, PI3K, Akt, ERK, NF-κB delayed cleavage procaspase 9 3 decrease...
S100A8 and S100A9 are important proteins in the pathogenesis of allergy.Asthma is an allergic lung disease, characterized by bronchial inflammation due to leukocytes, bronchoconstriction, allergen-specific IgE.In this study, we examined role interaction cytokine release from epithelial cells, with constitutive apoptosis neutrophils.S100A8 induce increased secretion neutrophil survival cytokines such as MCP-1, IL-6 IL-8.This suppressed TLR4 inhibitor), LY294002, AKT inhibitor, PD98059,...
S100 calcium-binding protein A8 (S100A8), a danger-associated molecular pattern, has emerged as an important mediator of the pro-inflammatory response. Some proteins play prominent role in neuroinflammatory disorders and increase secretion cytokines microglial cells. The aim this study was to determine whether S100A8 induced neuronal apoptosis during cerebral hypoxia elucidate its mechanism action. In study, we reported that expression increased mouse cells when exposed hypoxia,...
In this study, we investigated the effects of CCL2 on constitutive apoptosis normal and asthmatic neutrophils. blocked neutrophils through CCR2. also induced elevation cytosolic Ca(2+) concentration but had no effect neutrophil chemotaxis. Constitutive apoptosis, calcium influx, cell migration were not affected by stimulation. Supernatant collected from CCL2-treated inhibited Anti-apoptotic signaling mediated was found to be associated with PI3K/Akt/ERK/NF-κB cascade in Both cleavage...
S100A8 and S100A9 function as essential factors in inflammation, also exert anti-tumor or tumorigenic activity depending on the type of cancer. Chronic eosinophilic leukemia (CEL) is a rare hematological malignancy having elevated levels eosinophils, characterized by presence FIP1L1-PDGFRA fusion gene. In this study, we examined pro-apoptotic mechanisms FIP1L1-PDGFRα+ cells hypereosinophilic patient cells. induce apoptosis EoL-1 via TLR4. The surface TLR4 expression increased after exposure...
Acupuncture has long been used for pain relief. Although recent studies have shown that acupuncture can reduce neuropathic pain, the mechanism of this effect is not clear and little information available regarding proteins are involved in development effects acupuncture. We developed an animal model using young adult male Sprague-Dawley rats. The was confirmed by behavioral tests. Electroacupuncture (EA) treatment applied to Zusanli (ST36) examine analgesic EA. protein expression profile...
House dust mite (HDM) is a primary allergen in allergic rhinitis (AR) and asthma. Neutrophil apoptosis associated with diseases innate immunity to infection. The present study examined how HDM affects constitutive neutrophil normal AR subjects. Total IgE increased subjects when compared subjects, patients were HDM-specific positive (+), which specific Dermatophagoides pteronissinus farinae. In was inhibited by extract of (DP), but not farina (DF). Aprotinin (serine protease inhibitor) E64...
Signaling molecules that bind to chemokine receptors should play key roles in regulation of cell migration induced by chemokines. To characterize the CCR1-mediated cellular signal transduction mechanism, we used yeast two-hybrid system identify a ligand for CCR1. LZIP, which has been known as transcription factor various types, was identified CCR1 binding protein. Although ability LZIP DNA is possibly what allows it function factor, its detailed and participation chemotaxis have not...
Leukotactin‐1 (Lkn‐1)/CCL15 is a recently cloned CC‐chemokine that binds to the CCR1 and CCR3. Although Lkn‐1 has been known function as chemoattractant for neutrophils, monocytes lymphocytes, its cellular mechanism remains unclear. To understand of Lkn‐1‐induced chemotaxis signaling, we examined chemotactic activities human osteogenic sarcoma cells expressing in response using inhibitors signaling molecules. Inhibitors G i /G o protein, phospholipase C (PLC) protein kinase Cδ (PKCδ)...
(S)-(+)-Decursin is a coumarin compound present in herbal extracts that has various biological activities. attenuates pathophysiologic progression cancer, bacterial infection and neuropathy. Asthma an inflammatory disease associated with increased infiltration of leukocytes, especially eosinophils, secretion mucus into the airways. Although (S)-(+)-decursin, as well (S)-(+)-decursin analogues, have pharmacological properties, effect these compounds on asthma not known. In study, we...
Arazyme is a novel extracellular metalloprotease secreted by Aranicola proteolyticus. Endothelial cells are involved in the pathogenesis of number inflammatory diseases, induce uncontrolled cell viability and express various mediators, including cytokines, chemokines, adhesion molecules reactive oxygen species (ROS). In current study, human umbilical vein endothelilal (HUVECs) were used to investigate anti‑inflammatory effects arazyme following lipopolysaccharide (LPS) stimulation. Apoptosis...
Abstract Propionic acid (PPA) is a short-chain fatty that an important mediator of cellular metabolism. It also by-product human gut enterobacteria and common food preservative. A recent study found rats administered with PPA showed autistic-like behaviors like restricted interest, impaired social behavior, reversal in T-maze task. This aimed to identify link between autism phenotypes facilitated by signaling mechanisms hippocampal neurons. Findings indicated autism-like pathogenesis...
The glucocorticoid receptor (GR), a member of the nuclear superfamily, mediates effects glucocorticoids. It is known that 14-3-3 family proteins interact with GR and regulate its transcriptional activity. They also bind to several molecules influence many cellular events by altering their subcellular localization and/or acting as chaperone. Recently, it has been proposed ligand-activated degradation occurs via ubiquitin-proteasomal pathway inhibition proteasomal activity induces...
Asthma is an inflammatory airway disease. The pathogenic mechanisms of asthma include the infiltration leukocytes and release cytokines. Mimosa pudica (Mp) has been used traditionally for treatment insomnia, diarrhea diseases. Although Mp extract various therapeutic properties, effect this on not yet reported. This study investigated suppressive effects asthmatic responses both in vitro vivo. was acquired from dried powdered whole plants M. using 80% ethanol. BALB/c mice were mouse model...