A5038924500- Spinal Cord Injury Research
- Connective tissue disorders research
- Signaling Pathways in Disease
- Bone and Joint Diseases
- Mesenchymal stem cell research
- Stroke Rehabilitation and Recovery
- Osteoarthritis Treatment and Mechanisms
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Breast Cancer Treatment Studies
- Advances in Oncology and Radiotherapy
- Clinical practice guidelines implementation
- Extracellular vesicles in disease
Cardiff University
2024
Keele University
2019-2024
Robert Jones and Agnes Hunt Orthopaedic Hospital
2019-2021
Neurological outcomes following spinal cord injury (SCI) are currently difficult to predict. While the initial American Spinal Injury Association Impairment Scale (AIS) grade can give an estimate of outcome, high remaining degree uncertainty has stoked recent interest in biomarkers for SCI. This study aimed assess prognostic value routinely measured blood by developing models AIS scores at discharge and 12 months post-injury. Routine clinical data were collected from SCI patients (n = 417),...
There is increasing interest in the identification of biomarkers that could predict neurological outcome following a spinal cord injury (SCI). Although initial American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade good indicator outcome, for patient and clinicians, an element uncertainty remains. This preliminary study aimed to assess additive potential routine blood analytes principal component analysis (PCA) develop prognostic models SCI. Routine clinical data were...
Biomarkers are needed to predict clinical outcomes for microfracture and osteotomy surgeries ensure patients can be better stratified receive the most appropriate treatment.To identify novel biomarker candidates investigate potential of a panel protein biomarkers prediction outcome after treatment with or osteotomy.Descriptive laboratory study.To candidate proteins, we used label-free quantitation liquid chromatography-tandem mass spectrometry dynamic range-compressed synovial fluids (SFs)...
Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult predict, particularly in incompletely injured patients. The identification specific SCI biomarkers blood may able improve prognostics field. This study has utilized proteomic bioinformatic methodologies investigate differentially expressed proteins plasma samples across...
1. Abstract 1.1. Introduction Spinal Cord Injury (SCI) is a major cause of disability, with complications post-injury often leading to life-long health issues need extensive treatment. Neurological outcome post-SCI can be variable and difficult predict, particularly in incomplete injured patients. The identification specific SCI biomarkers blood, may able improve prognostics the field. This study has utilised proteomic bioinformatics methodologies investigate differentially expressed...