A5041157635- Advanced Control Systems Optimization
- Fault Detection and Control Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mineral Processing and Grinding
- Spectroscopy and Chemometric Analyses
- Advanced Control Systems Design
- Process Optimization and Integration
- Control Systems and Identification
- Drug Solubulity and Delivery Systems
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Coherence Tomography Applications
- Analytical Chemistry and Chromatography
- Simulation Techniques and Applications
- Protein purification and stability
- Scheduling and Optimization Algorithms
- Manufacturing Process and Optimization
Research Center Pharmaceutical Engineering (Austria)
2023-2025
Graz University of Technology
2019-2025
ConsiGmaTM-25 is a continuous production plant integrating twin-screw granulation, fluid bed drying, granule conditioning, and tableting unit. The particle size distribution (PSD), active pharmaceutical ingredient (API) content, liquid content of wet granules after granulation affect the quality intermediate final products. This paper proposes methods for real-time monitoring these quantities control-oriented modeling granulator. PSD monitored via an in-line process analytical technology...
Abstract Purpose The aim of this paper is the development a process control concept for hot melt extrusion (HME) and pelletization process. new should improve particle size distribution pellets produced. Methods Production containing an active pharmaceutical ingredient (API) can be achieved by means HME, followed step. quality produced depends on strand temperature at pelletizer’s inlet intake speed. This presents strategy diameter based adjusting cooling intensity track between HME step...
Real-time prediction of the dissolution behavior solid oral dosage forms is an important research topic. Although methods such as Terahertz and Raman can provide measurements that be linked to performance, they typically require a longer time offline for analysis. In this paper, we present novel strategy analyzing uncoated compressed tablets by means optical coherence tomography (OCT). Using OCT, which fast in-line capable, makes it possible predict based on images. our study, OCT images...