A5025375876- Granular flow and fluidized beds
- Rheology and Fluid Dynamics Studies
- Fluid Dynamics and Heat Transfer
- Particle Dynamics in Fluid Flows
- Cyclone Separators and Fluid Dynamics
- Polymer crystallization and properties
- Aerosol Filtration and Electrostatic Precipitation
- Inhalation and Respiratory Drug Delivery
- Engineering Technology and Methodologies
- Mineral Processing and Grinding
- Blood properties and coagulation
- Industrial Engineering and Technologies
- Coagulation and Flocculation Studies
- Electrostatics and Colloid Interactions
- Advanced machining processes and optimization
- Chemical Reactions and Mechanisms
- Drug Solubulity and Delivery Systems
- Chemical Reaction Mechanisms
- Lattice Boltzmann Simulation Studies
- Optical Coherence Tomography Applications
- Microencapsulation and Drying Processes
- Injection Molding Process and Properties
- Fluid Dynamics Simulations and Interactions
- Intravenous Infusion Technology and Safety
- Elasticity and Material Modeling
Research Center Pharmaceutical Engineering (Austria)
2022-2024
AstraZeneca (Sweden)
2009-2023
AstraZeneca (United Kingdom)
2013
University of California, Santa Barbara
1998-2000
The flow of carrier particles, coated with active drug is studied in a prototype dry powder inhaler. A novel, multiscale approach consisting discrete element model (DEM) to describe the particles coupled dynamic large eddy simulation (LES) nature applied. consists three different scales: micro‐scale, meso‐scale, and macro‐scale. At interactions small larger wall, air flow, each other thoroughly using modeling detailed computational fluid dynamics (CFD), i.e., resolving structures around...
The efficacy of nanostructured lipid carriers (NLC) for drug delivery strongly depends on their stability and cell uptake. Both properties are governed by compositions internal structure. To test the effect composition NLC uptake stability, three kinds liquid lipids with different degrees unsaturation employed. After ensuring homogeneous size distributions, thermodynamic characteristics, mixing characterized. Then rates predominant pathways determined. Although same surfactant is used in all...
Particle cycle and residence time distributions are critical factors in determining the coating quality Wurster process. Positron emission particle tracking experiments performed to determine times of particles different regions a fluid bed. The results show that tend recirculate sneak out below from tube. also larger batch size leads shorter narrower distribution (CTD). It is possible avoid recirculations obtain CTD by selecting operating conditions appropriately or via equipment design....
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Graham M. Harrison, Johan Remmelgas, L. Gary Leal; Comparison of dumbell-based theory experiment for a dilute polymer solution in corotating two-roll mill. J. Rheol. 1 January 1999; 43 (1): 197–218. https://doi.org/10.1122/1.550982 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Graham M. Harrison, Johan Remmelgas, L. Gary Leal; The dynamics of ultradilute polymer solutions in transient flow: Comparison dumbbell-based theory experiment. J. Rheol. 1 September 1998; 42 (5): 1039–1058. https://doi.org/10.1122/1.550924 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends...
Abstract The quality of a coated pharmaceutical tablet can be strongly affected by the interactions water droplets with porous substrate during processes such as coating process. Three different mechanisms co-exist in process: spreading, absorption and evaporation. Disentangling fundamental understanding these phenomena therefore crucial for achieving higher products (e.g. longer shelf-life tablets) controlling efficiency This paper aims to investigate spreading after droplet impingement on...
Fluidized bed coating has been used to coat pellets or tablets with functional substances for a number of purposes. In this process, particle wetting, drying and film formation are coupled motion. It is therefore interest study motion in such fluidized beds use the results develop model predicting quality final product. paper, we present from DEM-CFD simulations, i.e. discrete element method computational fluid dynamics simulations laboratory-scale Wurster that was also employed positron...