A5028659803- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Environmental Toxicology and Ecotoxicology
- Retinoids in leukemia and cellular processes
- Bacterial biofilms and quorum sensing
- Microplastics and Plastic Pollution
- Antimicrobial agents and applications
- biodegradable polymer synthesis and properties
- Fish Ecology and Management Studies
- Low-power high-performance VLSI design
- Synthesis of Tetrazole Derivatives
- Recycling and Waste Management Techniques
- PARP inhibition in cancer therapy
- Zebrafish Biomedical Research Applications
- Analog and Mixed-Signal Circuit Design
- Biochemical and Structural Characterization
- Physiological and biochemical adaptations
- Protein Hydrolysis and Bioactive Peptides
- Mercury impact and mitigation studies
- Marine Sponges and Natural Products
- Click Chemistry and Applications
- Oral microbiology and periodontitis research
- Graphene and Nanomaterials Applications
- Aldose Reductase and Taurine
- Tannin, Tannase and Anticancer Activities
University of Naples Federico II
2022-2024
Federico II University Hospital
2024
Microplastics have become a great worldwide problem and it's therefore important to study their possible effects on human environmental health. In this study, zebrafish embryos were used compare two different sizes of polystyrene microplastics (PS-MPs), 1 μm 3 respectively, at 0.01, 0.1, 1.0 10.0 mgL-1, monitored up 72 hours. Toxicity tests demonstrated that neither the PS-MPs altered embryos' survival normal hatching process. Instead, higher concentrations both caused an increase heart rate...
Candida species are the most common fungal pathogens infecting humans and can cause severe illnesses in immunocompromised individuals. The increased resistance of to traditional antifungal drugs represents a great challenge clinical settings. Therefore, novel approaches overcome desired. Here, we investigated use an antimicrobial peptide WMR against albicans non-albicans vitro vivo. Results showed activity on all planktonic cells at concentrations between 25 μM >50 exhibited sub-MIC inhibit...
During an infection, a single or multispecies biofilm can develop. Infections caused by non-dermatophyte molds, such as Fusarium spp. and yeasts, Candida spp., are particularly difficult to treat due the formation of mixed two species. oxysporum is responsible for approximately 20% human fusariosis, while albicans superficial mucosal dermal infections disseminated bloodstream with mortality rate above 40%. This study aims investigate interactions between C. F. dual-species biofilm,...
Aluminum (Al) is used in everyday life and present food drugs, packaging, industry, agriculture. Although it the most common metal Earth crust, a correlation has been demonstrated between its presence various pathologies, even serious ones, especially of neurological type. However, there histological gap regarding role Al can have contact with covering secreting epithelia. The alterations ventral dorsal foot mucocytes their secretions snail Eobania vermiculata caused by were investigated...
The increased incidence of mixed infections requires that the scientific community develop novel antimicrobial molecules. Essential oils and their bioactive pure compounds have been found to exhibit a wide range remarkable biological activities are attracting more attention. Therefore, aim this study was evaluate myrtenol (MYR), one constituents commonly in some essential oils, for its potential inhibit biofilms alone combination with drugs against Candida auris/Klebsiella pneumoniae single...
Microplastics (MPs) persist for long periods in the environment, causing adverse effects on aquatic and terrestrial ecosystems. The accumulation of MPs various trophic levels mostly depends weathering phenomena, their reduced dimensions improved bioavailability; this ultimately causes ingestion by organisms living different niches. modern concern about toxicity collides with current unavailability standardized reliable methodologies to assess risks associated exposure from habitats. Hence,...
Poly(ADPribosyl)ation is a post-translational protein modification, catalyzed by poly(ADP-ribose) polymerase (PARPs) enzymes, responsible for ADP-ribose polymer synthesis (PAR) from NAD+. PAR turnover assured poly(ADPR) glycohydrolase (PARGs) enzymes. In our previous study, the altered histology of zebrafish brain tissue, resulting in demyelination and neurodegeneration also with poly(ADPribosyl)ation hyperactivation, was demonstrated after aluminum (Al) exposure 10 15 days. On basis this...
In this study, we present data on the effects of condensed (CTs) and hydrolysable (HTs) tannins, polyphenols extracted from plants, at different concentrations zebrafish development to identify range with toxic effects. Zebrafish embryos were exposed CTs HTs two concentration ranges (5.0, 10.0, 20.0 μgL-1 5.0, mgL-1) for 72 h. The toxicity parameters observed up h treatment. uptake by larvae was assessed HPLC analysis. qRT-PCR analysis performed evaluate gene expression cd63, zhe1 klf4,...
The fungus Candida glabrata and the bacterium Staphylococcus epidermidis are important biofilm-forming microorganisms responsible of nosocomial infections in patients. In addition to causing single-species disease, these also involved polymicrobial leading an increased antimicrobial resistance. To expand knowledge about biofilms, this study we investigate formation single- dual-species biofilms two opportunistic pathogens employing several complementary approaches. First, biofilm biomass,...
Fungal infections are often consequent to prolonged antibiotic treatments. Vancomycin (Van) is the first-choice in treatment of Staphylococcus aureus associated with colonization catheter surfaces. We demonstrate direct effect Van promoting formation biofilm emergent yeast pathogen Candida auris, developed conventional polystyrene microwell plate model, as well on silicone surfaces (22 and 28% increase total biomass, respectively) an S. aures biofilm, residual after vancomycin treatment,...
Candida tropicalis is an emerging pathogen with a high mortality rate due to its virulence factors, including biofilm formation, that has important repercussions on the public health system. The ability of C. form biofilms, which are potentially more resistant antifungal drugs and consequent increasing antimicrobial resistance, highlights urgent need for development novel antifungal. present study analyzed antibiofilm capacity arylamidine T-2307 two strains tropicalis. Antimicrobial activity...
Gold complexes can be a useful system in the fight against cancer. Although many studies have been carried out on vitro 2D cell culture models embryotoxic assays are particularly lacking. Embryotoxicity and DNA damage critical concerns drug development. In this study, effects of new N-Heterocyclic carbene (NHC)-Au compound (Bromo[1,3-di-4-methoxybenzyl-4,5-bis(4-methoxyphenyl)imidazol-2-ylidene]gold(I)) at different concentrations were explored using multifaceted approach, encompassing...
In this study, we present data on the effects of condensed tannins (CTs) and hydrolysable (HTs), polyphenols extracted from plants, at different concentrations zebrafish development to identify range with toxic effects. Zebrafish embryos were exposed CTs HTs two concentration ranges (5.0-20.0 μgL-1 5.0-20.0 mgL-1) for 72 h. The toxicity parameters observed up h treatment. uptake by larvae was assessed via HPLC analysis. A qRT-PCR analysis performed evaluate expressions genes cd63, zhe1,...