A5038555688- Spine and Intervertebral Disc Pathology
- Veterinary Equine Medical Research
- Bone Tissue Engineering Materials
- Veterinary Orthopedics and Neurology
- Orthopaedic implants and arthroplasty
- Veterinary Oncology Research
- Microbial infections and disease research
- Turtle Biology and Conservation
- Animal Behavior and Welfare Studies
- Traumatic Ocular and Foreign Body Injuries
- Amphibian and Reptile Biology
- Virus-based gene therapy research
- Genetic and phenotypic traits in livestock
- Medical Imaging and Analysis
- Wildlife Ecology and Conservation
- Veterinary Medicine and Surgery
- Bone fractures and treatments
- Fish Ecology and Management Studies
- Rabies epidemiology and control
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Reproductive Physiology in Livestock
- Oral and Maxillofacial Pathology
- Tendon Structure and Treatment
- Xenotransplantation and immune response
University of Zagreb
2016-2025
Segmental defects of long bones are among the most challenging and debilitating conditions in clinical medicine. Osteogrow-C is a novel osteoinductive device composed recombinant human bone morphogenetic protein 6 (rhBMP6) delivered within autologous blood coagulum (ABC) with calcium phosphate ceramics that was proven efficacious preclinical models spinal fusion. This study aimed to evaluate efficacy comparison other therapies clinically relevant segmental defect model rabbits. (15 mm)...
Interpreting bovine hematology is essential for diagnosing, monitoring, and prognosing various diseases. One of the most commonly used diagnostic tool complete blood count (CBC), which helps identify a wide range organ systemic The purpose this review article to provide veterinarians, especially field with as much useful information possible, about hematological tests. Bovine can be great assistance in further testing predicting prognosis However, it should noted that diagnosis diseases...
In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within blood coagulum (ABC) used as a physiological carrier for new formation in spine fusion sheep models. The application ABGS included cervical cage use anterior lumbar interbody (ALIF), while posterolateral (PLF) model allograft devitalized particles (ALLO) were applied with and without instrumentation. ALIF model, (rhBMP6/ABC/cage) implants fused...
BMP2 and BMP7, which use bovine Achilles tendon-derived absorbable collagen sponge bone as scaffold, respectively, have been approved graft substitutes for orthopedic dental indications. Here, we describe an osteoinductive autologous substitute (ABGS) that contains recombinant human BMP6 (rhBMP6) dispersed within blood coagulum (ABC) scaffold. The ABGS is created injectable or implantable gel with rhBMP6 binding tightly to plasma proteins fibrin meshwork, examined by dot-blot assays,...
In the present study, we describe autologous blood coagulum (ABC) as a physiological carrier for BMP6 to induce new bone formation. Recombinant human (rhBMP6), dispersed within ABC and formed an graft substitute (ABGS), was evaluated either with or without allograft particles (ALLO) in rat subcutaneous implants posterolateral lumbar fusion (PLF) model rabbits. ABGS induced endochondral differentiation implants. Coating ALLO by significantly decreased formation of multinucleated foreign body...
Posterolateral lumbar fusion (PLF) is a commonly performed surgical procedure for the treatment of pathological conditions lumbosacral spine. In present study, we evaluated an autologous bone graft substitute (ABGS) containing rhBMP6 in blood coagulum (ABC) and synthetic ceramics used as compression resistant matrix (CRM) rabbit PLF model. pilot experiment, tested four different CRMs (BCP 500-1700 μm, BCP 1700-2500 μm two TCP form slabs) which were selected based on achieving uniform ABC...
Abstract Autologous bone graft substitute (ABGS) containing rhBMP6 in autologous blood coagulum (Osteogrow) is a novel therapeutic solution for regeneration. This study aimed to investigate the long-term outcome of ABGS with synthetic ceramics (Osteogrow-C) rabbit posterolateral spinal fusion (PLF) model. Osteogrow-C implants were implanted bilaterally between lumbar transverse processes. We compared following implantation ceramic particles different chemical composition (TCP and biphasic...
Management of large segmental defects is one the most challenging issues in bone repair biology. Autologous graft substitute (ABGS) containing rhBMP6 within autologous blood coagulum (ABC) with synthetic ceramics a novel biocompatible therapeutic solution for regeneration. A 2-year old dog was brought to veterinary clinics due pain and bleeding from right front leg after being unintendedly hit by gunshot. Radiological examination revealed large, 3 cm long multisegmental defect humerus on...
Abstract Elbow joint luxation without concomitant fracture is uncommon in horses. This paper reports on a case of elbow ten months old Arabian colt. The horse was presented with history an acute onset non-weight bearing right front limb lameness edema the affected region lasting for six days. Radiographic imaging indicated joint; however, useful information about severity soft tissue involvement obtained using ultrasonography since bilateral collateral ligaments were completely disrupted....
Posterolateral spinal fusion (PLF) is a procedure used for the treatment of degenerative spine disease. In this study we evaluated Osteogrow-C, novel osteoinductive device comprised recombinant human Bone morphogenetic protein 6 (rhBMP6) dispersed in autologous blood coagulum with synthetic ceramic particles, sheep PLF model. Osteogrow-C implants containing 74-420 or 1000-1700 µm particles (TCP/HA 80/20) were implanted between L4-L5 transverse processes (Ovis Aries, Merinolaandschaf breed)....
Abstract The aim of this study was to evaluate three combinations antibiotics applied perorally prior laparotomy and gastrointestinal surgery select the most favorable combination. Research performed on 24 female male dogs divided into four groups. Following abdominal wall incision caecum compressed manually 5 mL saline solution injected it. Five contents aspirated in a sterile syringe only 0.1 incubated blood agar homogenous agar. Bacterial colonies were counted determined. Prior control...
Joint disease has a high correlation with bull reproductive failure at semen collection centers or in natural breeding programs. The majority of changes involve the digital region, various etiologies and pathomorphologies. An X-ray examination is often indicated, but not become routine procedure bovine practice. aim our research was to determine radiographically visible region their anatomical distribution stud bulls that do show clinical signs lameness. To best knowledge, this first vivo...
The case describes a four-year-old Weimaraner bitch with fetal death resulting in the resorption of two gestation sacks and mummification fetus on day 30 gestation. An ultrasound diagnostic 22nd post-ovulation showed three normal sacks. check-up 3 days later only one sack no heartbeat observed, while diameter did not correspond to period. uterine wall was intact ovaries had corpus luteum bilaterally. clinical status patient physiological. On 32nd post-ovulation, an big solid cyst left ovary....
The aim of this study was to compare the effects two different anesthetic techniques on acid base balance in bitches.Research carried out 20 bitches randomly divided into groups.In group A general anaesthesia induced by intravenous application ketamine and diazepam, maintained with an additional bolus ketamine.In B a combination propofol used for induction anaestesia.General N 2 O range 1:1 2% isoflurane.Animals both groups were kept spontaneous ventilation.Arterial blood gas analysis taken...
An African pygmy hedgehog ( Atalerix albiventris ) (APH) was admitted to the clinic with a history of vaginal bleeding. Examination showed poor clinical status patient based on haemogram values. The ultrasound an enlarged uterus filled anechoic content without presence free abdominal fluid. Ovariohysterectomy performed under general inhalation anaesthesia. Histopathology examination tissue samples final diagnosis endometrial polyp cystic hyperplasia and chronic endometritis. In regard...
In a four-year old Australian Cattle Dog bitch, CT angiography of the communication azygos vein with interrupted caudal vena cava, without portocaval shunting is described.The discontinued cava usually an incidental finding which does not appear shunting.CT and 3D multiplanar reconstruction (MIP VR) enable us to distinguish processes regarding direction size anomalies blood vessels.By means imaging in two basic projections using velocity ratio (VR) significant enlargement significantly...