A5037471421- Chemical Synthesis and Analysis
- Lanthanide and Transition Metal Complexes
- Radiopharmaceutical Chemistry and Applications
- Supramolecular Self-Assembly in Materials
- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Advanced MRI Techniques and Applications
- Biochemical and Structural Characterization
- X-ray Diffraction in Crystallography
- Tuberculosis Research and Epidemiology
- Peptidase Inhibition and Analysis
- Antimicrobial Peptides and Activities
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Electrochemical sensors and biosensors
- Crystallization and Solubility Studies
- Magnetism in coordination complexes
- MRI in cancer diagnosis
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Trace Elements in Health
- Protein Hydrolysis and Bioactive Peptides
- Metal complexes synthesis and properties
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
University of Auckland
2015-2024
Nanjing Medical University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Maurice Wilkins Centre
2015-2019
Universidad de Guanajuato
2006-2017
The University of Texas Southwestern Medical Center
2002-2016
Advanced Imaging Research (United States)
2008-2016
The Nature Conservancy
2014
Southwestern Medical Center
2011
Universidad Nacional Autónoma de México
2010
The properties of a novel Gd3+-based MRI zinc sensor are reported. Unlike previously reported contrast agents, this agent (GdL) differs in that the alone binds only weakly with human serum albumin (HSA), while 1:2 GdL:Zn2+ ternary complex strongly to HSA resulting substantial, 3-fold increase water proton relaxivity. GdL is shown have relatively strong binding affinity for Zn2+ (KD = 33.6 nM), similar ion alone. detects as little 30 μM presence by vitro, value slightly more than total...
Elevation of postprandial glucose stimulates release insulin from granules stored in pancreatic islet β-cells. We demonstrate here that divalent zinc ions coreleased with β-cells response to high are readily detected by MRI using the Zn 2+ -responsive T 1 agent, GdDOTA-diBPEN. Image contrast was significantly enhanced mouse pancreas after injection a bolus followed low dose sensor. Images were not agent mice without addition stimulate release, nor images streptozotocin-treated or added...
Integrin α(V)β(3) plays a critical role in tumor angiogenesis and metastasis. Suitably radiolabeled cyclic RGD peptides can be used for noninvasive imaging of expression. The aim this research was to prepare multimeric system technetium-99m-labeled gold nanoparticles conjugated c[RGDfK(C)] evaluate its biological behavior as potential radiopharmaceutical molecular angiogenesis. Hydrazinonicotinamide-GGC (HYNIC-GGC) were synthesized (AuNP, 20 nm) by means spontaneous reaction the thiol groups...
Significance The normal prostate gland contains the most Zn(II) of all mammalian tissues, and there are marked differences in content between healthy, malignant, benign hyperplastic prostate. Given that multiparametric MRI does not always reliably distinguish these tissue conditions, release ions from response to an external stimulus may prove valuable as a specific biomarker cancer progression. In this work, we show glucose stimulates intracellular stores healthy secretion is reduced...
In this work the identification of peptides derived from quinoa proteins which could potentially self-assemble, and form hydrogels was carried out with TANGO, a statistical mechanical based algorithm that predicts β-aggregate propensity peptides. Peptides highest aggregate were subjected to gelling screening experiments most promising bioactive peptide sequence KIVLDSDDPLFGGF selected. The self-assembling hydrogelation properties C-terminal amidated (KIVLDSDDPLFGGF-NH
Synthetic azo dyes, such as tartrazine, sunset yellow and allura red have sensitive polarographic waves in solution (pH 9.2). However, the dyes are seriously overlapped making their simultaneous determination difficult without previous sample preparation. The aim of this work was to apply partial least squares (PLS) multivariate calibration commonplace electrochemical technique differential pulse polarography (DPP) for dye's three component mixture at trace levels (0.05–1.00 μmol/L). method...
DOTA was conjugated to the N-terminus of a 12-mer peptide by using standard synthesis chemistry. The peptide, first isolated phage display, maintained high affinity for its protein-binding target, Gal-80, even with GdDOTA attached. constant (KA = 5 × 105 M-1) combined relaxivity resulting GdDOTA-peptide·protein complex (r1bound 44.8 ± 1.7 mM-1 s-1) allowed detection Gal-80 at μM levels magnetic resonance imaging protocol. This novel peptide-based, binding-activated MRI method could...
The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to peptoid dimer known have high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with r1 relaxivity ∼48 mM−1 s−1 shown enhance MR images tumors grown in mice vivo.
The gastrin releasing peptide-receptor (GRP-r) is over-expressed in breast and prostate cancer lymph node metastases. Lys3-bombesin a peptide that binds with high affinity to GRP-r. aim of this research was prepare multifunctional system technetium-99m labelled gold nanoparticles conjugated Lys3-bombesin/HYNIC-GGC evaluate its biological behaviour as potential radiopharmaceutical for vivo GRP-r imaging.Lys3-bombesin hydrazinonicotinamide-Gly-Gly-Cys-NH2 (HYNIC-GGC) peptides were (AuNP, 20...
Colorful palette: A new class of highly selective Eu3+-based multi-frequency PARACEST agents is reported. The complexes can be tuned when administered simultaneously thereby allowing for the possibility monitoring multiple biomarkers in parallel. = paramagnetic chemical exchange saturation transfer. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors....
The conjugation of peptides to gold nanoparticles (AuNPs) produces biocompatible and stable multimeric systems with target‐specific molecular recognition. Peptides based on the cyclic Arg‐Gly‐Asp (RGD) sequence have been reported as high‐affinity agents for α ( ν ) β (3) integrin. aim this research was prepare a system 177 Lu‐labeled conjugated c(RGDfK)C (cyclo(Arg‐Gly‐Asp‐Phe‐Lys)Cys) compare radiation‐absorbed dose that monomeric dimeric RGD integrin‐positive U87MG tumors in mice. DOTA‐GGC...
A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported binding agent, the new agent binds to human albumin both in presence absence of Zn2+.