A5037950087- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Atmospheric chemistry and aerosols
- Peatlands and Wetlands Ecology
- Plant responses to elevated CO2
- Advanced Nanomaterials in Catalysis
- Hormonal Regulation and Hypertension
- Air Quality and Health Impacts
- Eicosanoids and Hypertension Pharmacology
- Pharmacogenetics and Drug Metabolism
- Osteoarthritis Treatment and Mechanisms
- Electrochemical sensors and biosensors
- Chemical Synthesis and Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon and Quantum Dots Applications
- Bone Tissue Engineering Materials
- Monoclonal and Polyclonal Antibodies Research
- Dynamics and Control of Mechanical Systems
- Asymmetric Synthesis and Catalysis
- Plant Water Relations and Carbon Dynamics
- Spinal Cord Injury Research
- Atmospheric and Environmental Gas Dynamics
- Synthesis and Catalytic Reactions
University of Greenwich
2022-2025
University of Leeds
2016-2025
Natural Resources Institute
2022-2025
Jiamusi University
2025
Tongji University
2021-2024
Tongji Hospital
2021-2024
Ministry of Education of the People's Republic of China
2020-2024
Northwest University
2020-2024
Northwestern Polytechnical University
2024
Guangdong Pharmaceutical University
2020-2023
A palladium-catalyzed asymmetric Markovnikov hydroaminocarbonylation of alkenes with anilines has been developed for the atom-economical synthesis 2-substituted propanamides bearing an α-stereocenter. novel phosphoramidite ligand L16 was discovered which exhibited very high reactivity and selectivity in reaction. This employs readily available starting materials tolerates a wide range functional groups, thus providing facile straightforward method regio- enantioselective under ambient...
Hydroaminocarbonylation of alkenes is one the most promising yet challenging methods for synthesis amides. Herein, we reported development a novel and effective Pd-catalyzed Markovnikov hydroaminocarbonylation 1,1-disubstituted or 1,1,2-trisubstituted with aniline hydrochloride salts to afford amides bearing an α quaternary carbon. The reaction makes use readily available starting materials, tolerates wide range functional groups, provides facile straightforward approach diverse array...
Abstract Asymmetric hydroxycarbonylation is one of the most fundamental yet challenging methods for synthesis carboxylic acids. Herein, we reported development a palladium‐catalyzed highly enantioselective Markovnikov vinyl arenes with CO and water. A monodentate phosphoramidite ligand L6 plays vital role in reaction. The reaction tolerates range functional groups, provides facile atom‐economical approach to an array 2‐arylpropanoic acids including several commonly used non‐steroidal...
In contrast to the kinetically favored outward isomerization-hydrocarbonylation of alkenes, disfavored inward alkenes remains an important challenge. Herein, we have developed a novel and effective palladium-catalyzed isomerization-hydroaminocarbonylation unactivated aniline hydrochlorides for formation synthetically valuable α-aryl carboxylic amides in high yields site-selectivities. The efficiency reaction is attributed relay catalysis strategy, which Markovnikov-favored [PdH]-P
Polyamides represent one class of materials that is important in modern society. Because the numerous potential applications polyamides various fields, there a high demand for new polyamide structures, which necessitates development polymerization methods. Herein, we report novel and efficient palladium-catalyzed hydroaminocarbonylative dienes diamines synthesis cycloaliphatic polyamides. The method employs readily available starting materials, proceeds an atom-economic manner, creates...
Abstract Background Mesenchymal stem cell (MSC) transplantation therapy is highly investigated for the regenerative repair of cartilage defects. Low-intensity pulsed ultrasound (LIPUS) has potential to promote chondrogenic differentiation MSCs. However, its underlying mechanism remains unclear. Here, we promoting effects and mechanisms LIPUS stimulation on human umbilical cord mesenchymal cells (hUC-MSCs) further evaluated application value in articular defects rats. Methods was applied...
Novel strategy for acid chlorides formation that do not use carboxylic acids is particularly attractive in chemical synthesis but remains challenging. Herein, we reported the development of a highly effective Pd-catalyzed hydrochlorocarbonylation alkenes with CO alkyl chlorides. Chlorosilane and AcOH were found as mild HCl source reaction. The reaction shows broad substrate scope produces both branched linear good to high yields upon different ligands solvents. Cooperating follow-up...
Abstract Chronic low back pain (LBP) caused by intervertebral disc (IVD) degradation is a serious socioeconomic burden that can cause severe disabilities. Addressing the underlying pathogenic mechanisms of IVD degeneration may inspire novel therapeutic strategy for LBP. Herein, hypoxic preconditioning improves both biological function MSCs in hostile microenvironments and enhances production small extracellular vesicles (sEVs) with desirable functions. In vitro results reveal preconditional...
Chronic low back pain and dyskinesia caused by intervertebral disc degeneration (IDD) are seriously aggravated become more prevalent with age. Current clinical treatments do not restore the biological structure inherent function of disc. The emergence tissue engineering regenerative medicine has provided new insights into treatment IDD. We synthesized biocompatible layered double hydroxide (LDH) nanoparticles optimized their ion elemental compositions to promote chondrogenic differentiation...
Spinal cord injury triggers complex pathological cascades, resulting in destructive tissue damage and incomplete repair. Scar formation is generally considered a barrier for regeneration the central nervous system. However, intrinsic mechanism of scar after spinal has not been fully elucidated. Here, we report that excess cholesterol accumulates phagocytes inefficiently removed from lesions young adult mice. Interestingly, observed excessive also injured peripheral nerves but subsequently by...
Northern wetlands are considered to be one of the most significant natural sources methane (CH4) emissions. The default wetland CH4 emission scheme in JULES, a current state-of-art land surface model, only takes into account emissions from inundated areas simple manner based on soil temperature and substrate availability. In this work, process-based peatland model HIMMELI was integrated with parameters were optimized measured flux at six northern sites for each site separately or multi-sites...