A5060419743- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Synthesis of β-Lactam Compounds
- Crystallography and molecular interactions
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Synthesis and Catalytic Reactions
- Neurotransmitter Receptor Influence on Behavior
- Cancer-related gene regulation
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Receptor Mechanisms and Signaling
- Curcumin's Biomedical Applications
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Chromatography
- Organic Chemistry Synthesis Methods
- Synthesis of Organic Compounds
- Chemical Synthesis and Reactions
- Synthesis and Biological Evaluation
- Cancer Treatment and Pharmacology
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Plant-based Medicinal Research
OncoArendi Therapeutics (Poland)
2023-2024
Polish Academy of Sciences
2016-2024
Institute of Organic Chemistry
2016-2024
University of Białystok
2004-2021
National Veterinary Research Institute
2016
Eukaryotic mRNAs undergo cotranscriptional 5′-end modification with a 7-methylguanosine cap. In higher eukaryotes, the cap carries additional methylations, such as m6Am─a common epitranscriptomic mark unique to mRNA 5′-end. This is regulated by Pcif1 methyltransferase and FTO demethylase, but its biological function still unknown. Here, we designed synthesized trinucleotide FTO-resistant N6-benzyl analogue of m6Am-cap–m7GpppBn6AmpG (termed AvantCap) incorporated it into using T7 polymerase....
Abstract Catalytic enantioselective Kinugasa reactions between acyclic and, for the first time, cyclic nitrones and terminal alkynes are described herein. A catalytic amount of readily available PINAP/CuX complexes, generated in situ, efficiently catalyzed reactions, leading to a series β‐lactams with good enantioselectivities moderate diastereoselectivities yields. broad range alkynes, including seldom reported alkyl‐substituted were tolerated under reaction conditions. Further...
Breast cancer is the most common of women-it affects more than 2 million women worldwide. PTP1B phosphatase can be one possible targets for new drugs in breast therapy. In this paper, we present curcumin derivatives featuring a 4-piperidone ring as inhibitors and ROS inducers. We performed cytotoxicity analysis twelve against MCF-7 MDA-MB-231 cell lines human keratinocyte HaCaT line. Furthermore, because known antioxidant, assessed antioxidant effects its derivatives. For potent cytotoxic...
Abstract The recent COVID-19 pandemics have demonstrated the great therapeutic potential of in vitro transcribed (IVT) mRNAs, but improvements their biochemical properties, such as cellular stability, reactogenicity and translational activity, are critical for further practical applications gene replacement therapy anticancer immunotherapy. One strategies to overcome these limitations is chemical modification a unique mRNA 5′-end structure, 5′-cap, which responsible regulating translation at...
A new approach to polymeric supports useful for the immobilization of aldehydes and ketones via hydrazone linkers is reported. The strategy gives with better properties effective synthesis all previously used alkylation anchored as hydrazones. In contrast other approaches, also provided a polymer an economical C2 spacer linker. were 3-pentanone, acetone, N-benzylpiperidone, hexanal 3-phenylpropanal in form their polymer-supported hydrazones subjected α-alkylation (LDA/RX) followed by acidic,...
Twelve alkyl analogues ( 1–12 ) of the high‐affinity serotonin transporter SERT inhibitor 6‐nitroquipazine (6‐ NQ were synthesized and studied using in vitro radioligand competition binding assays to determine their affinity K i ). The putative antidepressant activity five binders with highest affinities was by forced swim locomotor mouse tests. three‐dimensional (3 D structures 8 9 determined NOE NMR technique. Flexible docking compounds undertaken illustrate model. Our results showed that...
This review provides a comprehensive compilation of available literature concerning the synthesis and applications cyclic nitrones derived from sugars hydroxyacids. The most important recent developments concepts related to this topic are emphasized. Keywords: Carbohydrates, nitrones, cycloadditions, hydroxyacids, iminosugars, β-lactams.
The preparation of new solid supports with hydrazine anchoring groups and their application to solid-phase synthesis ketones primary amines are described. were used for immobilization ketones, 4-tert-butylcyclohexanone, pentan-3-one, acetone, N-methylpiperidone, N-benzylpiperidone, tropinone in the form hydrazones. polymer-supported hydrazones subjected deprotonation/alkylation procedure (LDA/RX) once or twice. resulting alkylated products cleaved off support on treatment trifluoroacetic...
A general synthetic route to the unknown 1,3‐dicarbonyl tropane derived curcumin analogues was developed. The method based on aldol condensation reaction (40–90 % yield, two steps without product isolation) and acylation of resulting 2‐benzylidenetropinones with substituted cinnamoyl cyanides (yields 41–91 %). Overall 18 new derivatives featuring characteristic curcuminoid hepta‐1,6‐dien‐3,5‐dione structure were synthesized characterized. range aromatic rings in prepared included Ph, m...
In the crystal structure of racemic title compound, C(22)H(25)NO(2), solved and refined against sychrotron diffraction data, hy-droxy group carbonyl O atom participate in formation O-H⋯O hydrogen bonds between pairs enanti-omers related by a crystallographic centre symmetry.
Abstract Noteworthy, the Cu salt is shown to have big influence on enantioselectivity of Kinugasa reaction in presence N‐PINAP ligands.
Abstract Eukaryotic mRNAs undergo co-transcriptional 5’-end modification with a 7-methylguanosine cap. In higher eukaryotes, the cap carries additional methylations, such as m6 A m – common epitranscriptomic mark unique to mRNA 5’-end. This is regulated by Pcif1 methyltransferase and FTO demethylase, but its biological function still unknown. Here, we designed synthesized trinucleotide FTO-resistant N 6-benzyl analog of -cap 7 Gppp Bn6 pG (termed AvantCap ) incorporated it into using T7...