A5039203052- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Tracheal and airway disorders
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Infant Health and Development
- Respiratory and Cough-Related Research
- Gut microbiota and health
- interferon and immune responses
- IL-33, ST2, and ILC Pathways
- Bacterial Infections and Vaccines
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Neonatal Respiratory Health Research
- Language Development and Disorders
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Infant Development and Preterm Care
- Viral Infections and Immunology Research
- Pacific and Southeast Asian Studies
- Dysphagia Assessment and Management
Turku University Hospital
2015-2024
University of Turku
2015-2024
Massachusetts General Hospital
2018-2022
Harvard University
2018-2022
Paulo Foundation
2016
Varsinais-Suomen Sairaanhoitopiiri
2016
Research Council of Finland
2016
Youth Development
2016
The Ohio State University
1983
Background: The burden of recurrent respiratory infections is unclear. We identified young children with in order to characterize the clinical manifestations, risk factors and short-term consequences. Methods: In this prospective cohort study, 1089 were followed from birth 2 years age for by a daily symptom diary. Nasal swabs taken during analyzed viruses 714 children. Nasopharyngeal collected at months cultured bacteria. 10% highest number annual illness days defined have tract infections....
Objective We explored the burden of respiratory tract infections (RTIs) in young children with regard to day-care initiation. Design Longitudinal prospective birth cohort study. Setting and methods recruited 1827 for follow-up until age 24 months collecting diary data on RTIs daycare. Children continuous daycare type complete were divided into groups centre-based (n=299), family day care (FDC) (n=245) home (n=350). Using repeated measures variance analyses, we analysed days per month...
Background Human nasopharynx is often colonized by potentially pathogenic bacteria. Gene polymorphisms in mannose-binding lectin (MBL), toll-like receptor (TLR) 2 and TLR4 have been reported. The present study aimed to investigate possible association between nasopharyngeal bacterial colonization gene of MBL, TLR2 healthy infants. Methodology/Principal Findings From August 2008 June 2010, 489 swabs 412 blood samples were taken from 3-month-old Finnish Semi-quantitative culture was performed...
BACKGROUND AND OBJECTIVES: Rhinoviruses frequently cause respiratory infections in young children. We aimed to establish the burden of acute caused by rhinovirus during first 2 years life. METHODS: In this prospective birth cohort study, we followed 923 children for from age. Data on were collected daily symptom diaries, study clinic visits, and electronic registries. Respiratory viruses detected reverse transcription-polymerase chain reaction antigen assays at age 2, 13, 24 months. The...
SUMMARY Children encounter repeated respiratory tract infections during their early life. We conducted a prospective clinical and serological follow-up study to estimate the syncytial virus (RSV) primary infection reinfection rates in childhood. Sera were collected from 291 healthy children at ages of 13, 24 36 months antibody levels against RSV antigens determined by enzyme immunoassay. The RT–PCR method was also used for identifying possible presence symptomatic patients. At 1, 2 3 years,...
Background Emerging evidence shows that airway microbiota may modulate local immune responses, thereby contributing to the susceptibility and severity of acute respiratory infections (ARIs). However, there are little data on longitudinal relationships between ARIs in children. Objective We aimed investigate association early nasal subsequent risk during first years life. Methods In this prospective population-based birth-cohort study Finland, we followed 839 healthy infants for from birth...
Abstract Background Early-life exposures to antibiotics may increase the risk of developing childhood asthma. However, little is known about mechanisms linking antibiotic We hypothesized that changes in nasal airway microbiota serve as a causal mediator antibiotics–asthma link. Methods In population-based birth-cohort study Finland, we identified longitudinal profiles during age 2–24 months using 16S rRNA gene sequencing and an unsupervised machine learning approach. performed mediation...
Although the airway microbiota is a highly dynamic ecology, role of longitudinal changes in during early childhood asthma development unclear. We aimed to investigate association nasal with risk developing asthma.In this prospective, population-based birth cohort study, we followed children from age 7 years. The was tested by using 16S ribosomal RNA gene sequencing at ages 2, 13, and 24 months. applied an unsupervised machine learning approach identify profiles 2 13 months (the primary...
Genome-wide association studies have identified several risk alleles for early childhood asthma, particularly in the 17q21 locus and cadherin-related family member 3 (CDHR3) gene. Contribution of these to acute respiratory tract infections (ARI) is unclear.We analyzed data from STEPS birth-cohort study unselected children VINKU VINKU2 on with severe wheezing illness. genotyping was performed 1011 children. We between 11 preselected asthma ARIs illnesses various viral etiologies.The CDHR3,...
Background An association between maternal prenatal stress and increased rates of respiratory tract infections in the offspring has been described earlier. Data regarding father's role is lacking. In this study our aim was to evaluate, whether mothers' fathers' depressive symptoms loneliness during pregnancy predict higher offspring. Methods longitudinal cohort we gathered information on parental psychological risk gestational week 20 using BDI-II UCLA scale questionnaires for parents 929...
Mannose-binding lectin (MBL) and toll-like receptors (TLRs) are important components of the innate immune system. We assessed susceptibility children with genetic variants in these factors to respiratory infections, rhinovirus infections acute otitis media.In a prospective cohort study, blood samples from 381 Finnish were analyzed for polymorphisms MBL2 at codons 52, 54 57, TLR2 Arg753Gln, TLR3 Leu412Phe, TLR4 Asp299Gly, TLR7 Gln11Leu TLR8 Leu651Leu. Children followed up until 24 months age...
Abstract The prevalence of seasonal human coronavirus (HCoV) infections in early childhood and adults has not been well analyzed longitudinal serological studies. Here we the changes HCoV (229E, HKU1, NL63, OC43, MERS, SARS-CoV-2) spike-specific antibody levels follow-up serum specimens 140 children at age 1, 2, 3 years, 113 healthcare workers vaccinated for Covid-19 with BNT162b2-vaccine. IgG against six recombinant spike subunit 1 (S1) proteins were measured by enzyme immunoassay. We show...
Respiratory viruses frequently cause symptomatic infections in children but are often detected also healthy children. We investigated myxovirus resistance protein A (MxA), viperin, and tripartite-motif 21 (TRIM21) messenger RNA indexes nasal swabs as potential biomarkers of viral respiratory infection were by polymerase chain reaction the same swabs. Nasal MxA viperin increased virus-positive index was found to be a robust marker tract with sensitivity 80% specificity 94% distinguishing...
Due to the diagnostic uncertainty concerning differentiation between viral and bacterial infections, children with infections are often treated antibiotics, predisposing them adverse effects contributing emerging antibiotic resistance. Since currently available biomarkers only estimate risk of infection, a biomarker for infection is needed in attempts reducing overuse.
Abstract Blood myxovirus resistance protein A (MxA) has broad antiviral activity, and it is a potential biomarker for symptomatic virus infections. Limited data available of MxA in coinciding viral bacterial We investigated blood levels children hospitalized with febrile urinary tract infection (UTI) or without simultaneous respiratory infection. conducted prospective observational study 43 UTI. Nasopharyngeal swab samples were collected at admission tested 16 viruses by nucleic acid...
Seasonal human coronaviruses (HCoVs) cause respiratory infections, especially in children. Currently, the knowledge on early childhood seasonal coronavirus infections and duration of antibody levels following first is limited. Here we analyzed serological follow-up samples to estimate rate primary infection reinfection(s) caused by childhood. Serum specimens were collected from 140 children at ages 13, 24, 36 months (1, 2, 3 years), IgG against recombinant HCoV nucleoproteins (N) measured...