A5016200755- Atrial Fibrillation Management and Outcomes
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Valve Diseases and Treatments
- Cancer Treatment and Pharmacology
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac tumors and thrombi
- Pericarditis and Cardiac Tamponade
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Coronary Artery Anomalies
- Genetic Neurodegenerative Diseases
- Vascular anomalies and interventions
- Radiation Dose and Imaging
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
University of South Florida
2013-2022
University of Alberta Hospital
2021
Janssen (United States)
2011-2019
Janssen Scientific Affairs (United States)
2011-2019
Moffitt Cancer Center
2017
Tampa General Hospital
2016-2017
AdventHealth Tampa
2016
Memorial Hospital
2016
Memorial Hospital
2014
Patel Hospital
2012
Objectives There is little information about arrhythmia burden in cancer survivors with chemotherapy-induced cardiomyopathy (CIC). We hypothesise that the rates and risk of arrhythmias will be similar CIC when compared other non-ischaemic (NICMO) aetiologies. Methods retrospectively identified nine patients an implantable defibrillator 18 age sex-matched control (nine NICMO ischaemic (ICMO)). Rates odds were calculated by type cardiomyopathy, adjusting for days since cardioverter...
Bortezomib is a proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. Traditionally, bortezomib was thought have little cardiovascular toxicity; however, there increasing evidence that can lead cardiac complications including left ventricular dysfunction atrioventricular block. We present the case of 66-year-old man with persistent asymptomatic elevations biomarkers who developed complete heart block myocardial scar after his eighth cycle bortezomib, requiring...
Background Left ventricular noncompaction ( LVNC ) is a rare disorder characterized by increased left trabeculation, deep intertrabecular recesses, and thin compacted myocardial layer with associated clinical sequelae. Cardiac imaging echocardiogram cardiac magnetic resonance CMRI can detect variable morphology including excessive trabeculations. Multiple echocardiographic criteria have been offered that attempt to identify morphology. The aim of this study was assess the utility in...
Friedreich's ataxia (FRDA) is an autosomal recessive disease, whereby homozygous inheritance of expanded GAA trinucleotide repeat expansion in the first intron FXN gene leads to transcriptional repression encoded protein frataxin. FRDA a progressive neurodegenerative disorder, but primary cause death heart disease which occurs 60% patients. Several functions frataxin have been proposed, none them fully explain why its deficiency causes phenotypes nor most affected cell types are neurons and...
Ventricular pseudoaneurysm is an uncommon, potentially fatal complication that has been associated with myocardial infarction, cardiac surgery, chest trauma, and infectious processes. Diagnosis can be challenging, as cases are rare slowly progressing typically lack identifiable features on clinical presentation. As a result, advanced imaging techniques have become the hallmark of identification. Ahead, we describe patient who presents acute decompensated heart failure was incidentally...
Background: Optimal timing to initiate anticoagulation after Acute Ischemic Stroke (AIS) from Atrial Fibrillation (AF) is currently unknown. Compared other stroke etiologies, AF typically provokes larger infarct volumes and greater concern of hemorrhagic transformation, so seminal randomized trials waited weeks-to-months begin initial stroke. Subsequent data limited nonrandomized. Guidelines suggest initiation windows between 3 14 days post-stroke, with Class IIa recommendations, level...
Central MessagePatients who undergo tricuspid valvectomy may develop symptoms of right-sided heart failure and require operative reintervention with valve replacement.See Commentary on page 68. Patients replacement. See The incidence infective endocarditis secondary to intravenous (IV) drug abuse has risen sharply during the opioid epidemic in United States.1Slaughter M.S. Badhwar V. Ising M. Ganzel B.L. Sell-Dottin K. Jawitz O.K. et al.Optimum surgical treatment for endocarditis: an...
The effects of Echinacea purpurea on electrocardiographic and blood pressure measurements in healthy volunteers were evaluated.Healthy randomized to receive a single 350-mg dose E. or placebo crossover fashion with seven-day washout period between treatment phases. Twelve-lead electrocardiograms acquired, systolic diastolic taken immediately before (baseline) at one, three, five, eight hours after ingestion the study drug. Electrocardiographic variables (P wave QRS complex duration PR, Q-T,...
Abstract Based upon its interactions with amyloid β peptide (Aβ), the amylin receptor, a Class B G protein-coupled receptor (GPCR), is potential modulator of Alzheimer’s disease (AD) pathogenesis. However, past pharmacological approaches have failed to resolve whether activation or blockade this would greater therapeutic benefit. To address issue, we generated compound mice expressing human precursor protein gene familial AD mutations in combination deficiency receptors produced by...
Peripartum cardiomyopathy is an uncommon, pregnancy-related form of dilated that associated with development new-onset left ventricular dysfunction. Its etiology presently unknown, but current standard care involves the use typical drug therapy for treatment heart failure. Pregnancy-associated (PACM) a similar condition refers to patients who develop such symptoms prior last month pregnancy. We report case nulliparous Caucasian female develops early, severe PACM during her first pregnancy...