A5090755424- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Advanced Proteomics Techniques and Applications
- Analytical chemistry methods development
- Advanced Chemical Physics Studies
- Ion-surface interactions and analysis
- Metabolomics and Mass Spectrometry Studies
- Chemical Reaction Mechanisms
- Protein Structure and Dynamics
- Chromium effects and bioremediation
- Chemical Synthesis and Analysis
- Metal complexes synthesis and properties
- Various Chemistry Research Topics
- Enzyme Structure and Function
- DNA and Nucleic Acid Chemistry
- Electrochemical Analysis and Applications
- Inorganic and Organometallic Chemistry
- Photochemistry and Electron Transfer Studies
- Ionic liquids properties and applications
- Catalysis and Oxidation Reactions
- Microfluidic and Capillary Electrophoresis Applications
- Biopolymer Synthesis and Applications
- Chemical Thermodynamics and Molecular Structure
- Synthesis and Properties of Aromatic Compounds
- Vanadium and Halogenation Chemistry
University of Alabama
2011-2023
Miami University
1991-2001
United States Naval Research Laboratory
1993
Purdue University West Lafayette
1983-1991
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExperimental and ab initio studies of the gas-phase basicities polyglycinesKui Zhang, David M. Zimmerman, Alice Chung-Phillips, Carolyn J. CassadyCite this: Am. Chem. Soc. 1993, 115, 23, 10812–10822Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ja00076a044https://doi.org/10.1021/ja00076a044research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvidence for an externally bound iron+-buckminsterfullerene complex, FeC60+, in the gas phaseL. M. Roth, Y. Huang, J. T. Schwedler, C. Cassady, D. Ben-Amotz, B. Kahr, and S. FreiserCite this: Am. Chem. Soc. 1991, 113, 16, 6298–6299Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ja00016a071https://doi.org/10.1021/ja00016a071research-articleACS...
Gas-phase deprotonation reactions, hydrogen–deuterium exchange reactions and collision-induced dissociation (CID) were used to distinguish between two isomeric forms of [M+12H]12+ produced from the protein ubiquitin. Ions generated by electrospray ionization studied in a Fourier transform ion cyclotron resonance mass spectrometer. For formed directly process, with ammonia 2-fluoropyridine yield non-linear pseudo-first-order kinetic behavior that indicates presence structures. The fraction...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConsecutive collision-induced dissociations in Fourier transform mass spectrometryR. B. Cody, R. C. Burnier, J. Cassady, and S. FreiserCite this: Anal. Chem. 1982, 54, 13, 2225–2228Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/ac00250a021https://doi.org/10.1021/ac00250a021research-articleACS PublicationsRequest reuse permissionsArticle...
The gas-phase deprotonation reactions of multiply protonated ubiquitin ions have been studied in a Fourier-transform ion cyclotron resonance mass spectrometer. Electrospray ionization was used to generate with attachment 7-13 protons. Rate constants were measured for the these protein four amines: n-propylamine, di-n-propylamine, tri-n-propylamine, and N,N,N',N'-tetramethyl-1,4-diaminobutane. basicities amines ranged from 210.1 kcal/mol 232.6 kcal/mol. rate found increase as charge state...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-phase reactions of transition-metal ions with methyl nitrite and nitromethaneC. J. Cassady B. S. FreiserCite this: Am. Chem. Soc. 1985, 107, 6, 1566–1573Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00292a019https://doi.org/10.1021/ja00292a019research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations65LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-phase reactions of Group VIII metal hydride ions (FeD+, CoD+, and NiD+) with hydrocarbonsT. J. Carlin, L. Sallans, C. Cassady, D. B. Jacobson, S. FreiserCite this: Am. Chem. Soc. 1983, 105, 20, 6320–6321Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/ja00358a027https://doi.org/10.1021/ja00358a027research-articleACS PublicationsRequest...
The gas-phase acidities of the 20 L-amino acids have been predicted at composite G3(MP2) level. A broad range structures neutral and anion were studied to determine lowest energy conformer. Excellent agreement is found with available experimental deprotonation enthalpies, calculated values are within error. We predict that tyrosine deprotonated CO(2)H site. Cysteine be SH but proton on shared S(-) Self-consistent reaction field (SCRF) calculations COSMO parametrization used pK(a)'s...
Protonations of α- and β-d-glucopyranose in the gas phase were investigated using ab initio molecular orbital approach at HF/6-31G* level with full geometry optimization. Minimum-energy structures three neutral six protonated species for each anomer calculated. Geometries, energies, intramolecular hydrogen bonding these are discussed. For 298 K order stability hydroxymethyl conformers is calculated to be GT > GG TG α β anomer. Protonated that least disrupt internal network considered;...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAb Initio Studies of Neutral and Protonated Triglycines: Comparison Calculated Experimental Gas-Phase BasicityKui Zhang, Carolyn J. Cassady, Alice Chung-PhillipsCite this: Am. Chem. Soc. 1994, 116, 25, 11512–11521Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ja00104a035https://doi.org/10.1021/ja00104a035research-articleACS PublicationsRequest...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExperimental and Ab Initio Studies on Protonations of Alanine Small Peptides GlycineCarolyn J. Cassady, Scott R. Carr, Kui Zhang, Alice Chung-PhillipsCite this: Org. Chem. 1995, 60, 6, 1704–1712Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/jo00111a031https://doi.org/10.1021/jo00111a031research-articleACS PublicationsRequest reuse permissionsArticle...
Collision-induced dissociation (CID) was performed on multiply deprotonated ions from three commercial peptides: hirudin (54-65), fibrinopeptide B, and oxidized insulin chain A. Ions were produced by electrospray ionization in a Fourier transform ion cyclotron resonance mass spectrometer. Each of these peptides contains multiple acidic residues, which makes them very difficult to ionize the positive mode. However, deprotonate readily making negative studies viable alternative. The CID...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-phase reactions of tantalum carbide cluster ions with deuterium and small hydrocarbonsCarolyn J. Cassady Stephen W. McElvanyCite this: Am. Chem. Soc. 1990, 112, 12, 4788–4797Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ja00168a025https://doi.org/10.1021/ja00168a025research-articleACS PublicationsRequest reuse permissionsArticle...
A new matrix-assisted laser desorption ionization (MALDI) mass spectrometry matrix is proposed for molecular and structural determination of glycans. This contains an iron oxide nanoparticle (NP) core with gluthathione (GSH) molecules covalently bound to the surface. As demonstrated monosaccharide glucose several larger glycans, spectra exhibit good analyte ion intensities signal-to-noise ratios, as well exceptionally clean background in low mass-to-charge (m/z) region. In addition, abundant...
The gas-phase basicities (GB) of histidine, lysine, and di- triglycyl peptides containing either one histidine or lysine residue have been determined. In all, 12 compounds were examined in a Fourier transform ion cyclotron resonance mass spectrometer. GBs the biomolecules evaluated by proton transfer reactions employing range reference with varying basicities. addition, determined using kinetic method collision-induced dissociation on proton-bound dimer peptide compound. both found to be...
The gas-phase deprotonation reactions of multiply protonated bovine ubiquitin, insulin chain B, and renin substrate tetradecapeptide ions have been studied in a Fourier transform ion cyclotron resonance mass spectrometer coupled with an external electrospray source. Rate constants were measured for the these peptide series reference compounds known basicities ranging from 195.6 to 232.6 kcal/mol. apparent acidities (GAapp) [M + nH](n+) determined reactions. deduced values GAapp show strong...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of the iron(1+) ion-hydroxyl and cobalt(1+) bond energies by deprotonation reactions photodissociationC. J. Cassady B. S. FreiserCite this: Am. Chem. Soc. 1984, 106, 21, 6176–6179Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://pubs.acs.org/doi/10.1021/ja00333a009https://doi.org/10.1021/ja00333a009research-articleACS PublicationsRequest reuse...
Electron transfer dissociation (ETD) and collision-induced (CID) were used to investigate underivatized, metal-cationized oligosaccharides formed via electrospray ionization (ESI). Reducing non-reducing sugars studied including the tetrasaccharides maltotetraose, 3α,4β,3α-galactotetraose, stachyose, nystose, a heptasaccharide, maltoheptaose. Univalent alkali, divalent alkaline earth, trivalent transition metal ions, boron group ion adducted non-permethylated oligosaccharides. ESI generated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduction and fragmentation of tantalum carbide cluster ionsStephen W. McElvany Carolyn J. CassadyCite this: Phys. Chem. 1990, 94, 5, 2057–2062Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/j100368a061https://doi.org/10.1021/j100368a061research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations40LEARN ABOUT THESE...
Small peptides ions consisting of a comparable number amino acid residues but varying in composition and sequence were allowed to undergo gas-phase deprotonation reactions. These multiply protonated generated by electrospray ionization analyzed Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The studied contain 11–14 included adrenocorticotropic hormone (ACTH) fragment (11–24), fibrinopeptide B (human), gastrin I (1–13) renin substrate tetradecapeptide (horse),...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-phase reactions of molybdenum oxide ions with small hydrocarbonsCarolyn J. Cassady and Stephen W. McElvanyCite this: Organometallics 1992, 11, 7, 2367–2377Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/om00043a017https://doi.org/10.1021/om00043a017research-articleACS PublicationsRequest reuse permissionsArticle Views140Altmetric-Citations38LEARN...
The gas-phase basicity (GB) of proline, which is the only imino acid and reported to play a significant role in protein folding, was determined by deprotonation reactions Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Protonated peptide ions were generated fast atom bombardment an external source. GB proline found be 213.3 kcal/mol. Among dipeptides studied, glycylproline (GlyPro) 214.8 kcal/mol, while prolylglycine (ProGly) 4.2 kcal/mol more basic (GB = 219.0...