A5011712973- Pharmacogenetics and Drug Metabolism
- Cannabis and Cannabinoid Research
- Drug Transport and Resistance Mechanisms
- Pancreatic function and diabetes
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Effects and Toxicity Studies
- Pancreatic and Hepatic Oncology Research
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Forensic Toxicology and Drug Analysis
- Pregnancy and Medication Impact
- Chronic Lymphocytic Leukemia Research
- Respiratory and Cough-Related Research
- Computational Drug Discovery Methods
- Biomedical Ethics and Regulation
- Metabolomics and Mass Spectrometry Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Effects and risks of endocrine disrupting chemicals
- Acute Lymphoblastic Leukemia research
- Analytical Methods in Pharmaceuticals
- Ethics in Clinical Research
- Chronic Myeloid Leukemia Treatments
University of Washington
2024-2025
University of North Carolina at Chapel Hill
2021-2024
Cannabidiol (CBD) is a naturally occurring nonpsychotoxic phytocannabinoid that has gained increasing attention as popular consumer product and for its use in Food Drug Administration–approved Epidiolex (CBD oral solution) the treatment of Lennox-Gastaut syndrome Dravet syndrome. CBD was previously reported to be metabolized primarily by CYP2C19 CYP3A4, with minor contributions from UDP-glucuronosyltransferases. 7-Hydroxy-CBD (7-OH-CBD) primary active metabolite equipotent activity compared...
Cannabinoid use has surged in the past decade, with a growing interest expanding cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) applications into special populations. Consequently, increased of CBD THC raises risk drug–drug interactions (DDIs). Nevertheless, DDIs for cannabinoids, especially populations, remain inadequately investigated. While some clinical trials have explored between therapeutic drugs like antiepileptic CBD/THC, more potential to be examined. This review...
Sunitinib is an orally administered tyrosine kinase inhibitor associated with idiosyncratic hepatotoxicity; however, the mechanisms of this toxicity remain unclear. We have previously shown that cytochromes P450 1A2 and 3A4 catalyze sunitinib metabolic activation via oxidative defluorination leading to a chemically reactive, potentially toxic quinoneimine, trapped as glutathione (GSH) conjugate (M5). The goals study were determine impact interindividual variability in 1A 3A activity on...
The cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) undergo extensive oxidative metabolism in the liver. Although cytochromes P450 form primary, pharmacologically active, hydroxylated metabolites of CBD THC, less is known about enzymes that generate major vivo circulating 7-carboxy-CBD 11-carboxy-THC, respectively. purpose this study was to elucidate involved forming these metabolites. Cofactor dependence experiments with human liver subcellular fractions revealed...
Cannabidiol (CBD) is approved for treatment of seizures associated with two forms epilepsy that become apparent in infancy or early childhood. To consider an adult physiologically-based pharmacokinetic (PBPK) model pediatric scaling, we assessed vitro-derived cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT) enzyme contributions to CBD clearance human. An i.v. PBPK was constructed using physicochemical properties knowledge disposition. The datasets were used...
E-cigarette, or vaping product use-associated lung injury (EVALI), is a severe respiratory disorder that caused sudden outbreak of hospitalized young people in 2019. Using cannabis oil containing products, including vitamin E acetate contaminants, was found to be strongly associated with EVALI. However, the underlying tissue impacts condition are still largely unknown. Here, we focused on vehicle cannabinoid (CBD oil) and contaminant (VEA) effects airway epithelial cells. Primary human...
Informed consent is the process of obtaining permission from human participants to use their cells and tissues or otherwise include them in research studies. With informed consent, scientists can experiments learn more about body test new medicines. This article describes how these are obtained, ethical concerns regarding research. The story Henrietta Lacks her immortal HeLa cell line discussed, demonstrate importance showcase Henrietta’s valuable contributions modern medicine.
Aims Serum, liver and urinary bile acids are increased, hepatic transport protein levels decreased in a non‐clinical model of polycystic kidney disease. Similar changes patients with autosomal dominant disease (ADPKD) may predispose them to drug‐induced injury (DILI) drug–drug interactions (DDIs). Systemic coproporphyrin‐I (CP‐I), an endogenous biomarker for OATP1B function MRP2 substrate, is used evaluate OATP1B‐mediated DDI risk humans. In this clinical observational cohort‐comparison...
Abstract Venetoclax is a first‐in‐class orally administered B‐cell lymphoma‐2 inhibitor used to treat chronic lymphocytic leukemia (CLL). primarily metabolized in the liver by cytochrome P450 (CYP) 3A4 its major metabolite M27, via M5, and M2, M3, M4 oxidation. Although venetoclax breakthrough CLL treatment, managing drug safety toxicity remains clinical challenge. The objectives of this study were investigate how individual CYP3A activity protein expression affect hepatic metabolism vitro...
Cannabidiol (CBD) is a naturally occurring, non-psychotoxic phytocannabinoid that has gained public attention for its use as an active ingredient in many consumer products and recent FDA approval Epidiolex® (CBD oral solution) treating seizures associated with Lennox-Gastaut syndrome Dravet syndrome. been dose-dependent hepatotoxicity clinical trials, the risk increased when given valproate, another anti-epileptic drug known to cause liver injury. The mechanism of CBD-related hepatotoxicity,...
<b>Abstract ID 24159</b> <b>Poster Board 23</b> Sunitinib is a tyrosine kinase inhibitor (TKI) used to treat cancers such as imatinib-resistant gastrointestinal stromal tumors. This TKI has been associated with hepatotoxicity in some patients taking the drug, and numerous studies have conducted order test mechanisms of sunitinib. The goal this study was evaluate time- dose-dependent toxicity sunitinib using 3-D human hepatic spheroid model. Cryopreserved hepatocytes from single donor were...
Sunitinib is an orally administered tyrosine kinase inhibitor used to treat renal cell carcinoma, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. The product label for sunitinib carries a boxed warning idiosyncratic hepatotoxicity; however, the mechanisms of this toxicity remain unclear. We have previously shown that cytochrome P450 (CYP) 1A2 CYP3A4 catalyze metabolic activation via oxidative defluorination form chemically reactive, potentially toxic quinoneimine,...
Cannabidiol (CBD), a natural product derived from cannabis, was recently FDA-approved to treat epilepsy in children. CBD is extensively metabolized by hepatic cytochrome P450 (P450) enzymes form the pharmacologically active metabolite 7-hydroxy-cannabidiol (7-OH-CBD). This further converted major circulating metabolite, 7-carboxy-cannabidiol (7-COOH-CBD), prior hepatobiliary excretion. mainly eliminated of 7-COOH-CBD and related hydroxylated derivatives, plasma area under curve up 40 times...