A5053274063- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- COVID-19 Clinical Research Studies
- Health, psychology, and well-being
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
- Ion channel regulation and function
- Cannabis and Cannabinoid Research
- Apelin-related biomedical research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Alkaloids: synthesis and pharmacology
- Nicotinic Acetylcholine Receptors Study
- Wnt/β-catenin signaling in development and cancer
- Traditional and Medicinal Uses of Annonaceae
- Treatment of Major Depression
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
University of Guelph
2018-2024
EVERSANA (Canada)
2022
Abstract Background Major depressive disorder (MDD) is a recurring affective that two times more prevalent in females than males. Evidence supports immune system dysfunction as major contributing factor to MDD, notably sexually dimorphic manner. Nuclear erythroid 2-related 2 (Nrf2), regulator of antioxidant signalling during inflammation, dysregulated many chronic inflammatory disorders; however, its role depression and the associated sex differences have yet be explored. Here, we...
Major depressive disorder is a chronic illness with higher incidence in women. Dysregulated neural oscillatory activity an emerging mechanism thought to underlie major disorder, but whether sex differences these rhythms contribute the development of symptoms unknown.We exposed male and female rats unpredictable stress characterized them as stress-resilient or stress-susceptible based on behavioural output forced swim test sucrose preference test. To identify sex-specific patterns associated...
Mitragynine is the major alkaloid of Mitragyna speciosa (kratom) with potential as a therapeutic in pain management and depression. There has been debate over side effects drug including addiction risk cognitive decline.To evaluate mitragynine on neurophysiological systems function prefrontal cortex (PFC), cingulate (Cg), orbitofrontal cortex, nucleus accumbens (NAc), hippocampus (HIP), thalamus (THAL), basolateral amygdala (BLA) ventral tegmental area rats.Local field recordings were taken...
To estimate the clinical and economic benefits of lenzilumab plus standard care (SOC) compared with SOC alone in treatment hospitalized COVID-19 patients from National Health Service (NHS) England perspective.A cost calculator was developed to costs adding newly over 28 days. The LIVE-AIR trial results informed inputs: failure achieve survival without ventilation (SWOV), mortality, time recovery, intensive unit (ICU) admission, invasive mechanical (IMV) use. Base case included drug...
Abstract Major Depressive Disorder (MDD) is a chronic illness with higher incidence in women. Dysregulated neural oscillatory activity an emerging mechanism underlying MDD, however whether sex differences these rhythms contribute to the development of MDD symptoms unknown. Using unpredictable stress model, we found that stress-resilient and susceptible animals exhibited sex-specific markers prefrontal cortex, cingulate nucleus accumbens hippocampus. Resilient females were predominantly...
The methylazoxymethanol acetate (MAM) rodent model is used to study aspects of schizophrenia. However, numerous studies that have employed this only males, resulting in a dearth knowledge on sex differences brain function and behaviour. purpose was determine whether exist between male female MAM rats neuronal oscillatory within the prefrontal cortex (PFC), ventral hippocampus (vHIP) thalamus, behaviour, proteins linked schizophrenia neuropathology. We showed animals exhibited region-specific...
Cortical circuit dysfunction is thought to be an underlying mechanism of schizophrenia (SZ) pathophysiology with normalization aberrant activity proposed as a biomarker for antipsychotic efficacy. Cannabidiol (CBD) shows potential adjunctive therapy; however, sex effects in these drug interactions remain unknown. In the present study, we sought elucidate CBD coadministration atypical iloperidone (ILO) on primary cortical neuron cultures derived from rat methylazoxymethanol acetate (MAM)...
Abstract Background Major depressive disorder (MDD) is a recurring affective that two times more prevalent in females than males. Evidence supports immune system dysfunction as major contributing factor to MDD, notably sexually dimorphic manner. Nuclear erythroid 2-related 2 (Nrf2), regulator of antioxidant signaling during inflammation, dysregulated many chronic inflammatory disorders, however its role depression and the associated sex differences have yet be explored. Here we investigated...
Abstract Purpose Estimate the clinical and economic benefits of lenzilumab plus standard care (SOC) compared with SOC alone in treatment hospitalized COVID-19 patients from National Health Service (NHS) England perspective. Methods A cost calculator was developed to estimate costs adding newly over 28 days. The LIVE-AIR trial results informed inputs: failure achieve survival without ventilation (SWOV), mortality, time recovery, intensive unit (ICU) admission, invasive mechanical (IMV) use....