A5057889423- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Infectious Diseases and Tuberculosis
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Surgical site infection prevention
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Hematological disorders and diagnostics
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Osteomyelitis and Bone Disorders Research
- Surgical Sutures and Adhesives
- Drug-Induced Adverse Reactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Rheumatoid Arthritis Research and Therapies
- Tuberculosis Research and Epidemiology
- Bone fractures and treatments
- Neutropenia and Cancer Infections
- Bacterial biofilms and quorum sensing
- Herpesvirus Infections and Treatments
- Fungal Infections and Studies
- Orthopedic Surgery and Rehabilitation
- Nosocomial Infections in ICU
Mayo Clinic
2016-2025
Mayo Clinic in Florida
2011-2024
WinnMed
2012-2023
Mayo Clinic in Arizona
2008-2022
Mayo Clinic Hospital
2021
University of Minnesota Rochester
2003-2020
Office of Infectious Diseases
2002-2017
American Academy of Orthopaedic Surgeons
2013
American Dental Association
2013
American Association of Neurological Surgeons
2013
Abstract These guidelines are intended for use by infectious disease specialists, orthopedists, and other healthcare professionals who care patients with prosthetic joint infection (PJI). They include evidence-based opinion-based recommendations the diagnosis management of PJI treated debridement retention prosthesis, resection arthroplasty or without subsequent staged reimplantation, 1-stage amputation.
Culturing of samples periprosthetic tissue is the standard method used for microbiologic diagnosis prosthetic-joint infection, but this neither sensitive nor specific. In microorganisms are typically present in a biofilm on surface prosthesis. We hypothesized that culturing obtained from prosthesis would improve infection.
Abstract These guidelines are intended for use by infectious disease specialists, orthopedists, and other healthcare professionals who care patients with prosthetic joint infection (PJI). They include evidence-based opinion-based recommendations the diagnosis management of PJI treated debridement retention prosthesis, resection arthroplasty or without subsequent staged reimplantation, 1-stage amputation.
We conducted a matched case-control study to determine risk factors for the development of prosthetic joint infection. Cases were patients with hip or knee Controls who underwent total arthroplasty and did not develop A multiple logistic regression model indicated that infection surgical site involving prosthesis (odds ratio [OR], 35.9; 95% confidence interval [CI], 8.3-154.6), National Nosocomial Infections Surveillance (NNIS) System patient index score 1 (OR, 1.7; CI, 1.2-2.3) 2 3.9;...
We recently described a sonication technique for the diagnosis of prosthetic knee and hip infections. compared periprosthetic tissue culture to implant followed by sonicate fluid shoulder infection. One hundred thirty-six patients undergoing arthroplasty revision or resection were studied; 33 had definite infections 2 probable Sonicate was more sensitive than detection infection (66.7 54.5%, respectively; P = 0.046). The specificities similar (98.0% 95.1%, 0.26). Propionibacterium acnes...
Abstract Objective Prosthetic joint infection is one of the most dreaded complications after total arthroplasty, a common procedure in patients with rheumatoid arthritis (RA). We conducted study to evaluate potential risk factors prosthetic and clarify if RA an independent predictor this complication. Methods This included all who underwent hip or knee replacement at Mayo Clinic Rochester between January 1996 June 2004. The association was examined using Cox models. A matched cohort...
ABSTRACT Periprosthetic tissue and/or synovial fluid PCR has been previously studied for prosthetic joint infection (PJI) diagnosis; however, few studies have assessed the utility of on biofilms dislodged from surface explanted arthroplasties using vortexing and sonication (i.e., sonicate PCR). We compared 16S rRNA gene real-time sequencing to culture fluid, tissue, microbiologic diagnosis PJI. sequences generating mixed chromatograms were decatenated RipSeq Mixed. fluids 135 231 subjects...
Debridement and retention of the prosthesis was initial treatment modality in 30 patients with 33 Staphylococcus aureus prosthetic joint infections (PJIs) who presented to Mayo Clinic between 1980 1991. Treatment failure, defined as relapse S. PJI or occurrence culture-negative during continuous antistaphylococcal therapy, occurred 21 joints. The 1-year 2-year cumulative probabilities failure were 54% (95% confidence interval [CI], 36%-71%) 69% CI, 52%-86%), respectively. A median 4...
Forty-two patients (forty-two hips) who had an infection following a hip arthroplasty were managed with open débridement, retention of the prosthetic components, and antibiotic therapy. After mean duration follow-up 6.3 years (range, 0.14 to twenty-two years), only six (14 per cent)—four nineteen early postoperative two four acute hematogenous infection—had been successfully. Of remaining thirty-six patients, three (7 cent entire group) being chronic suppression oral administration...
Selman Waksman (Figs 1, 2) came to the United States from Imperial Russia in 1910 when he was his early 20s. He entered Rutgers University New Jersey a year later and became soil microbiologist at Agriculture College there. observed that certain fungi suppressed growth of mycobacterium tuberculosis eventually workers laboratory (including co-authors on this classic article, Albert Schatz Elizabeth Bugie) isolated one proved extremely effective minimally toxic-streptomycin.Fig 1.: (right) is...
The purpose of this study was to assess the systemic safety and potential adverse effects using a high-dose antibiotic-impregnated cement spacer after resection arthroplasty an infected total knee replacement. Between October 2000 December 2002, 36 knees (34 patients) had prosthesis with placement antibiotic impregnated spacer. There were 24 men 10 women mean age 66.5 years (range, 48–84 years). All spacers placed contained average 3.4 batches dose 10.5 g vancomycin 3–16 g) 12.5 gentamicin...
The actual risk of prosthetic joint infection as a result dental procedures and the role antibiotic prophylaxis have not been defined. To examine association between with or without hip knee infection, prospective, single-center, case-control study for period 2001–2006 was performed at 1200-bed tertiary care hospital in Rochester, Minnesota. Case patients were hospitalized total infection. Control subjects who underwent arthroplasty but during same on orthopedic floor. Data regarding...
ABSTRACT Explanted orthopedic implants from 54 patients with aseptic failure and 24 prosthetic knee or hip infection were sonicated in polyethylene bags. The sensitivities of periprosthetic tissue sonicate fluid cultures for the diagnosis joint 54% 75%, whereas specificities 98% 87%, respectively. Sonication bags improved bacterial recovery surface implants; however, it lacked specificity, due to bag leakage.
C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have been shown to be useful for diagnosis of prosthetic hip knee infection. Little information is available on CRP ESR in patients undergoing revision or resection shoulder arthroplasties spine implants.We analyzed preoperative 636 subjects who underwent (n=297), (n=221) (n=64) arthroplasty, implant (n=54) removal. A standardized definition orthopedic implant-associated infection was applied. Receiver operating curve analysis...
Clinical characteristics and control of the infection patients with culture-negative (CN) prosthetic joint (PJI) have not been well assessed. Prior use antimicrobial therapy has speculated but proven as a risk factor for CNPJI.We therefore determined whether prior therapy, PJI, postoperative wound healing complications were associated CN PJI.We performed retrospective case-control study 135 PJI treated between January 1, 1985, December 31, 2000 matched culture-positive (CP) PJIs (control...
We previously showed that culture of samples obtained by prosthesis vortexing and sonication was more sensitive than tissue for prosthetic joint infection (PJI) diagnosis. Despite improved sensitivity, culture-negative cases remained; furthermore, has a long turnaround time. designed genus-/group-specific rapid PCR assay panel targeting PJI bacteria applied it to sonicating explanted hip knee prostheses, we compared the results those with sonicate fluid periprosthetic at revision or...
Two-stage reimplantation is the most accepted mode of treatment for patients with a periprosthetic infection following total knee arthroplasty. Most studies, however, do not stratify their results on basis type infecting organism. The purpose this study was to determine outcomes who had two-stage resistant organism, methicillin-resistant Staphylococcus aureus or epidermidis, at site replacement.A multicenter performed review cases all treated between 1987 and 2003 because an epidermidis...