A5107537939- Angiogenesis and VEGF in Cancer
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- MRI in cancer diagnosis
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- PARP inhibition in cancer therapy
- Gastric Cancer Management and Outcomes
- CRISPR and Genetic Engineering
- Carcinogens and Genotoxicity Assessment
- Effects of Radiation Exposure
- Advanced MRI Techniques and Applications
- Radiation Therapy and Dosimetry
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
University of Oxford
2015-2024
AstraZeneca (United Kingdom)
2005-2023
CRUK/MRC Oxford Institute for Radiation Oncology
2014-2023
Bioscience (China)
2023
Cancer Research UK
1991-2021
Medical Research Council
2014-2021
Wake Forest University
2020
University of Alberta
2013
The University of Texas MD Anderson Cancer Center
2007-2012
Martin Luther University Halle-Wittenberg
2011
There is no effective therapy for patients with advanced medullary thyroid carcinoma (MTC). Vandetanib, a once-daily oral inhibitor of RET kinase, vascular endothelial growth factor receptor, and epidermal receptor signaling, has previously shown antitumor activity in phase II study hereditary MTC.Patients MTC were randomly assigned 2:1 ratio to receive vandetanib 300 mg/d or placebo. On objective disease progression, could elect open-label vandetanib. The primary end point was...
G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously shown that HR facilitates telomere replication. Here, we demonstrate the efficiency of guanine-rich (G-rich) telomeric repeats is decreased significantly in cells lacking HR. Treatment with G4-stabilizing...
Camptothecin is a specific topoisomerase I poison and highly cytotoxic to eukaryotic cells. In the present study, we show, using pulse field gel electrophoresis assay, that camptothecin induces DNA double strand breaks (DSBs) specifically in newly replicated DNA. these replication associated DSBs dose-dependent manner. At levels of drug which are toxic cell, long-lived, still measurable 24 hr after treatment. Both induced cytotoxicity prevented by co-exposure with aphidicolin--a result...
Abstract Purpose: Vascular endothelial growth factor (VEGF) signaling is key to tumor angiogenesis and an important target in the development of anticancer drugs. However, VEGF receptor (VEGFR) expression human cancers, particularly relative VEGFR-2 VEGFR-3 vasculature versus cells, poorly defined. Experimental Design: VEGFR-2– VEGFR-3–specific antibodies were identified used immunohistochemical analysis primary cancers normal tissue. The vascular localization both receptors colorectal...
Abstract Purpose: The resistance to selective EGFR inhibitors involves the activation of alternative signaling pathways, and Akt VEGF induction have been described in inhibitor–resistant tumors. Combined inhibition other proteins has become a successful therapeutic approach, stimulating search for further determinants as basis novel strategies. Experimental Design: We established human cancer cell lines with various degrees expression sensitivity analyzed signal transducers under control...
Purpose There is an unmet need for biomarkers identifying patients likely to benefit from anticancer treatments, selecting dose, and understanding mechanisms of resistance. Plasma vascular endothelial growth factor (VEGF) soluble VEGF receptor 2 (sVEGFR-2) are known be modulated by pathway inhibitors. It unknown whether chemotherapy or VEGFR inhibitor/chemotherapy combinations induce changes in these other cytokines angiogenic factors (CAFs) such could markers benefit. Methods Thirty-five...
Article27 May 2019Open Access Source Data RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinoma Daniela Pankova Department of Oncology, University Oxford, UK Search for more papers by this author Yanyan Jiang Oxford Institute Radiation Maria Chatzifrangkeskou orcid.org/0000-0003-3703-491X Iolanda Vendrell TDI Mass Spectrometry Laboratory, Nuffield Medicine, Target Discovery Jon Buzzelli Anderson Ryan Cameron Brown School Chemistry, Physics Mechanical...
Abstract Purpose: ZD6126 is a novel vascular targeting agent currently undergoing clinical evaluation. It acts by destabilizing the microtubulin of fragile and proliferating neoendothelial cells in tumors. The drug leads to blood vessel congestion, selective destruction vasculature, extensive necrosis experimental aim study reported here was assess ability dynamic contrast enhanced magnetic resonance imaging (MRI) measure antivascular effects Experimental Design: work carried out mice...
Abstract Purpose: Circulating endothelial cells (CEC) comprise at least two distinct populations: bone marrow–derived circulating progenitors (CEP) and mature CECs derived from existing vasculature. We hypothesized that antiangiogenic agents may have differential effects on CEPs these changes serve as a marker of biological activity. Experimental Design: The effect angiogenesis inhibitors was evaluated by flow cytometry after vascular growth factor (VEGF)–induced mobilization in mice bearing...
Abstract Purpose: The Src family comprises a of nonreceptor intracellular tyrosine kinases that mediate variety cellular pathways. are overexpressed in human tumors, including cancer the colon, breast, and pancreas, they an integral part tumor cell signaling pathways associated with migration, proliferation, adhesion, angiogenesis. Experimental Design: We investigated whether blockade kinase by daily oral administration novel inhibitor AZM475271 [kindly provided AstraZeneca (Macclesfield,...
Abstract Patients with hereditary medullary thyroid carcinoma (MTC) associated multiple endocrine neoplasia (MEN) types 2A and 2B familial MTC (FMTC) have mutations in the RET proto-oncogene. Approximately 40 percent of patients papillary (PTC) typically either intrachromosomal or extrachromosomal rearrangements that join promoter NH2-terminal domains unrelated genes to COOH-terminal fragment RET. The point MEN2A, MEN2B, FMTC, chromosomal breakpoints translocations PTC, activate receptor...
Abstract Purpose: Resistance to VEGFR inhibitors is a major obstacle in the treatment of non–small cell lung cancer (NSCLC). We investigated cellular mechanisms mediating resistance NSCLCs tyrosine kinase inhibitors. Experimental Design: generated murine models human NSCLC and performed targeted inhibition studies with TKIs cediranib vandetanib. used species-specific hybridization microarrays compare (human) stromal (mouse) transcriptomes TKI-sensitive -resistant tumors. measured tumor...
Research Article20 July 2017Open Access Source DataTransparent process BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity Eliana MC Tacconi Department of Oncology, Genome Stability Tumorigenesis Group, The CR-UK/MRC Oxford Institute for Radiation University Oxford, UK Search more papers by this author Xianning Lai Cecilia Folio Manuela Porru Area Translational Research, Regina Elena National Cancer Institute, Rome, Italy Gijs Zonderland Sophie Badie Johanna...
Potentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeutic strategy to improve outcomes for patients with solid tumors. However, this approach risks enhancing normal tissue toxicity much tumor toxicity, thereby limiting its translational impact. Using NU5455, newly identified highly selective oral inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity, we found that it was indeed possible preferentially augment the effect...