A5069480605- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Cancer therapeutics and mechanisms
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Computational Drug Discovery Methods
- Complement system in diseases
- Heat shock proteins research
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Hippo pathway signaling and YAP/TAZ
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Systemic Lupus Erythematosus Research
- Effects of Radiation Exposure
- CRISPR and Genetic Engineering
University of Oxford
2014-2024
CRUK/MRC Oxford Institute for Radiation Oncology
2014-2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
117th Hospital of People's Liberation Army
2022
Cancer Research UK
2016-2019
University of California, Davis
2016-2019
Medical Research Council
2016-2019
Pennsylvania State University
2019
National Natural Science Foundation of China
2018
To investigate whether autoantibodies to ion channels and other neural antigens are present in the sera of patients with epilepsy seizure-related diseases.Sera were obtained from 139 patients, including 26 preexisting autoimmune disease, 46 whom an basis was suspected, 67 drug-resistant epilepsy. The assayed for antibodies voltage-gated potassium (VGKC) calcium (VGCC) channels, glutamic acid decarboxylase (GAD), gangliosides, glutamate receptor type 3, cardiolipins, DNA, nuclear antigens;...
Article27 May 2019Open Access Source Data RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinoma Daniela Pankova Department of Oncology, University Oxford, UK Search for more papers by this author Yanyan Jiang Oxford Institute Radiation Maria Chatzifrangkeskou orcid.org/0000-0003-3703-491X Iolanda Vendrell TDI Mass Spectrometry Laboratory, Nuffield Medicine, Target Discovery Jon Buzzelli Anderson Ryan Cameron Brown School Chemistry, Physics Mechanical...
Epithelia are positioned at a critical interface to prevent invasion by microorganisms from the environment. Pattern recognition receptors important components of innate immunity because their ability interact with specific microbe-associated structures and initiate immune responses. Several distinct groups have been recognized. One these, scavenger receptors, has classified into least eight separate classes. The class A characterized presence collagen-like domain include macrophage receptor...
<b><i>Objective:</i></b> To determine the prevalence of serum antibodies to ionotropic glutamate receptor 3 (GluR3) in patients with Rasmussen encephalitis (RE), a severe epileptic disorder, and compare from control subjects intractable epilepsy (IE). <b><i>Methods:</i></b> The authors looked for immunoglobulin (Ig) G GluR3 30 RE, including two who had plasma exchange 12 been treated IV Igs varying results, 49 IE 23 healthy individuals, using ELISA GluR3B peptide, Western blot analysis...
The potential association between microbial infection and reactivation of a multiple sclerosis (MS) lesion is an important issue that remains unresolved, primarily because the absence suitable animal models imaging techniques. Here, we have evaluated this question in empirical manner using immunohistochemistry magnetic resonance (MRI), before after induction systemic inflammatory response two distinct MS. In pattern-II-type focal myelin oligodendrocyte glycoprotein-experimental autoimmune...
Potentiating radiotherapy and chemotherapy by inhibiting DNA damage repair is proposed as a therapeutic strategy to improve outcomes for patients with solid tumors. However, this approach risks enhancing normal tissue toxicity much tumor toxicity, thereby limiting its translational impact. Using NU5455, newly identified highly selective oral inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity, we found that it was indeed possible preferentially augment the effect...
// Sivan M. Bokobza 1 , Yanyan Jiang Anika Weber Aoife Devery and Anderson J. Ryan Gray Institute for Radiation Oncology & Biology, Department of Oncology, University Oxford, Old Road Campus Research Building, Headington, UK Correspondence: J Ryan, email: Keywords : EGFR, lung cancer, AKT, Chloroquine Received March 20, 2014 Accepted May 25, Published 27, Abstract Although non-small cell cancer (NSCLC) patients with EGFR mutation positive (EGFR M+) tumors initially respond well to tyrosine...
Poly(ADP-ribose) polymerase (PARP) inhibitors potentiate radiation therapy in preclinical models of human non-small cell lung cancer (NSCLC) and other types cancer. However, the mechanisms underlying radiosensitization vivo are incompletely understood. Herein, we investigated impact hypoxia on by PARP inhibitor olaparib NSCLC xenograft models.
Abstract TNF‐α has proved to be a successful target in the treatment of many peripheral inflammatory diseases, but same interventions worsen immune‐mediated CNS disease. However, anti‐TNF‐α strategies may offer promise as therapy for non‐immune injury. In this study, we have microinjected IL‐1β or lipopolysaccharide (LPS) into rat brain simple model injury and systemically administered antagonist etanercept discover whether hepatic TNF‐α, produced part acute‐phase response injury, modulates...
Vascular endothelial growth factor (VEGF) is a key stimulator of physiological and pathological angiogenesis. VEGF signals primarily through receptor 2 (VEGFR2), tyrosine kinase whose expression found predominantly on cells. The purpose this study was to determine the role VEGFR2 in NSCLC cells tissue sections were stained for by immunohistochemistry (IHC). Immunoblotting ELISA used activation inhibition its downstream signalling pathways. Five-day proliferation assays carried out presence...
Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need develop novel targeted for this subtype cancer. Inhibition heat shock protein 90 (HSP90), conserved molecular chaperone that involved regulation oncogenic client proteins, has shown be promising therapeutic approach TNBC. However, both intrinsic acquired resistance HSP90 inhibitors (HSP90i) limits their effectiveness cancer patients. We developed models HSP90i by...
Cytokines, including tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6), have been implicated in the pathogenesis of multiple sclerosis (MS). The production release these cytokines are regulated part by specific purinergic (adenosine) cell surface receptors. To determine extent to which adenosine A1 receptor influenced cytokine expression peripheral blood mononuclear cells (PBMCs) from MS control patients, we measured plasma TNFα levels, messenger RNA (mRNA) protein amounts, effects...
Abstract The majority of individuals with multiple sclerosis (MS) exhibit T‐cell‐ and macrophage‐dominated lesions (patterns I II; as opposed to III IV). These lesions, in turn, may be distinguished on the basis whether or not there are immunoglobulin complement depositions at sites active myelin destruction; such found exclusively pattern II lesions. main aim this study was determine MS distinct MRI signatures. We have used a recently described focal MOG‐induced EAE model rat brain, which...
Cardiac electrophysiology and Ca2+ handling change rapidly during the fight-or-flight response to meet physiological demands. Despite dramatic differences in cardiac electrophysiology, is highly conserved across species. In this study, we performed sympathetic nerve stimulation (SNS) while optically mapping action potentials intracellular transients innervated mouse rabbit hearts. similar heart rate responses between hearts, found notable species spatio-temporal repolarization dynamics SNS....
An immunosuppressive microenvironment causes poor tumor T cell infiltration and is associated with reduced patient overall survival in colorectal cancer. How to improve treatment responses these tumors still a challenge. Using an integrated screening approach identify cancer-specific vulnerabilities, we identified complement receptor C5aR1 as druggable target, which when inhibited improved radiotherapy, even displaying features CD8+ infiltration. While well-known for its role the immune...
Tumours can be categorised based on their stromal architecture into tumour vessel and phenotypes, the phenotypes have been suggested to define response chronic treatment with a VEGFR2 antibody. However, it is unclear whether vascular of tumours associate acute VEGFR tyrosine kinase inhibitors (TKI), or early changes in function are associated subsequent size. This study was sought address these questions by using xenograft models human non-small cell lung cancer (NSCLC) representing...