A5082721307- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Neurogenetic and Muscular Disorders Research
- Genetics and Neurodevelopmental Disorders
- Protein Tyrosine Phosphatases
- Protein Kinase Regulation and GTPase Signaling
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Calcium signaling and nucleotide metabolism
Memorial Sloan Kettering Cancer Center
2018-2020
Icahn School of Medicine at Mount Sinai
2010-2013
Neurodegenerative diseases cause tremendous suffering for those afflicted and their families. Many of these involve accumulation mis-folded or aggregated proteins thought to play a causal role in disease pathology. Ubiquitinated are often found protein aggregates, the aggregates themselves have been shown inhibit activity proteasome. These other alterations Ubiquitin Pathway observed neurodegenerative led question whether impairment on its own can increase mortality if ongoing...
Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification differentiated tissues cancer. Rabex-5 (also called RabGEF1) inhibits by promoting mono- and di-ubiquitination. We report here that Rabex-5-mediated ubiquitination requires Tyrosine 4 (Y4), a site known phosphorylation. substitution mutants insensitive to Y4 phosphorylation did not undergo cells exhibited gain-of-function phenotypes vivo. phosphomimic...