A5020791541- Mosquito-borne diseases and control
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Malaria Research and Control
- Insect Resistance and Genetics
- HIV Research and Treatment
- Adipose Tissue and Metabolism
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Pharmacology and Obesity Treatment
- Sirtuins and Resveratrol in Medicine
- COVID-19 diagnosis using AI
- Forensic and Genetic Research
- Insect symbiosis and bacterial influences
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- COVID-19 epidemiological studies
- Liver Disease Diagnosis and Treatment
- Genetic diversity and population structure
- Antioxidant Activity and Oxidative Stress
- Delphi Technique in Research
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Diabetes and associated disorders
Universidad México Americana del Norte
2018-2024
Texas A&M University – San Antonio
2023-2024
The University of Texas Rio Grande Valley
2016-2023
Universidad Autónoma de la Ciudad de México
2013-2022
The University of Texas Health Science Center at Houston
2018-2019
Hershey (United States)
2019
Humana (United States)
2016
Center for Research and Advanced Studies of the National Polytechnic Institute
2005-2014
Instituto de Estudios Avanzados
2013
Instituto Politécnico Nacional
2006-2013
Abstract Background Culex spp. mosquitoes are considered to be the most important vectors of West Nile virus (WNV) detected in at least 34 species United States. In North America, pipiens pipiens, quinquefasciatus , and tarsalis all competent WNV, which is enzootic States has also been equines birds many states Mexico humans Nuevo Leon. There potential for WNV introduced into City by various means including infected on airplanes, migrating birds, ground transportation humans. Little known...
Abstract Background Dengue viruses (DENV) attach to the host cell surface and subsequently enter by receptor-mediated endocytosis. Several primary low affinity co-receptors for this flavivirus have been identified. However, presence of these binding molecules on does not necessarily render susceptible infection. Determination which them serve as bona fide receptors virus in vector may be relevant treating DENV infection designing control strategies. Results (1) Overlay protein assay showed...
The main vector of dengue in America is the mosquito Aedes aegypti, which infected by virus (DENV) through receptors midgut epithelial cells. envelope protein (E) binds to present on host cells its domain III that has been primarily recognized bind cell receptors. In order identify potential receptors, proteins from tissue and C6/36 were purified affinity using columns with recombinant E (rE-DIII) or DENV particles bound covalently Sepharose 4B compare evaluate their performance including...
La epidemia de COVID-19 ha modificado la cultura comunicación. solución para los problemas salud puede ser asertiva cuando es consensuada. El método Delphi una herramienta consenso que emplea rondas listas preguntas recopilar información del conocimiento un panel expertos analizan planteamientos y posibles soluciones a problemas. Se basa en premisa que, con libertad anonimato, inteligencia combinada mejora el juicio individual captura opinión colectiva experta. proceso muy flexible, pues las...
Abstract Background Dengue (DEN) is a serious cause of mortality and morbidity in the world including Mexico, where infection endemic. One states with highest rate dengue cases Oaxaca. The DEN positive-sense RNA virus, virus (DENV) that evolves rapidly increasing its variability due to absence repair mechanism leads approximately one mutational event per genome replication; which results enhancement viral adaptation, escape from host immune responses. Additionally, recombination may play...
Genetic variants have been replicated for association with type 2 diabetes mellitus (T2D) and many of them diabetes-related traits. Because T2D is highly prevalent in Mexico, this study aimed to test the CDKN2A/B, PPARGC1A, VEGFA, SIRT1 UCP2 gene polymorphisms (rs10811661, rs8192678, rs2010963, rs7896005 rs659366 respectively) metabolic traits 415 unrelated Mexican mestizos under three models inheritance.A total were genotyped by TaqMan assays. Triglycerides, cholesterol, glucose,...
Here; we have described and tested a microarray based-method for the screening of dengue virus (DENV) serotypes. This DNA assay is specific sensitive can detect dual infections with two serotypes single-serotype infections. Other methodologies may underestimate samples containing more than one serotype. technology be used to discriminate between four DENV Single-stranded targets were covalently attached glass slides hybridised labelled probes. isolates evaluate performance. Our results...
Aim Acanthosis nigricans (AN) is a strong correlate of obesity and considered marker insulin resistance (IR). AN associated with various other cardiometabolic risk factors (CMRFs). However, the direct causal relationship IR in has been debated. Therefore, we aimed to examine complex relationships among troika AN, obesity, Mexican Americans (MAs). Methods We used data from 670 non-diabetic MA children, aged 6–17 years (49% girls). (prevalence 33%) severity scores (range 0–5) were as...
Prior studies have identified various determinants of differential immune responses to COVID-19. This study focused on the Ig-G anti-RBD marker, analyzing its potential correlations with sex, vaccine type, body fat percentage, metabolic risk, perceived stress, and previous COVID-19 exposure. In this study, data (available in S1 Data) were obtained from 108 participants ESFUERSO cohort, who completed questionnaires detailing their experiences stress levels assessed through SISCO scale. IgG...
Abstract High concentrations of carotenoids are protective against cardiometabolic risk traits (CMTs) in adults and children. We recently showed non-diabetic Mexican American (MA) children that serum α-carotene β-carotene inversely correlated with obesity measures triglycerides positively HDL cholesterol they were under strong genetic influences. Additionally, we previously described a Pediatric Metabolic Index (PMI) helps the identification who at for diseases. Here, quantified lycopene...
The Rio Grande Valley (RGV) in South Texas has one of the highest prevalence obesity and type 2 diabetes (T2D) United States (US). We report for first time T2D persons with HIV (PWH) RGV interrelationship between T2D, cardiometabolic risk factors, HIV-related indices, antiretroviral therapies (ART). PWH this study received medical care at AIDS Council (VAC) clinic sites located Harlingen McAllen, Texas. Henceforth, cohort will be referred to as Cohort (VACC). Cross-sectional analyses were...
Patterns of gene flow vary greatly among Aedes aegypti populations throughout Mexico. The are panmictic along the Pacific coast, isolated by distance in northeast Mexico, and exhibit moderate across Yucatan peninsula. Nine Ae. collections from 6 cities Oaxaca, were taken to examine local patterns flow. Genetic variation was examined a 387-bp region nicotinamide adenine dinucleotide dehydrogenase subunit 4 mitochondrial (ND4) using single-strand conformation polymorphism analysis, 3...
Aims: Maya ancestry populations from Yucatan have exhibited a high prevalence of diabetes and obesity; consequently, the aim this study was to determine allelic genotype frequencies six polymorphisms associated with obesity in two populations.
CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles:A>G; G risk allele) polymorphism CCL2 cis -regulatory region increased expression vitro ex vivo, leukocyte mobilization deleterious disease outcomes. However, molecular basis for rs1024611-associated differential remains poorly characterized. It...
CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles:A>G; G risk allele) polymorphism CCL2 cis -regulatory region increased expression vitro ex vivo, leukocyte mobilization deleterious disease outcomes. However, molecular basis for rs1024611-associated differential remains poorly characterized. It...
Abstract CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles:A>G; G risk allele) polymorphism CCL2 cis -regulatory region increased expression vitro ex vivo, leukocyte mobilization deleterious disease outcomes. However, molecular basis for rs1024611-associated differential remains poorly...