A5063350520- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Graphene and Nanomaterials Applications
- MXene and MAX Phase Materials
- Crystallization and Solubility Studies
- Advancements in Transdermal Drug Delivery
- 2D Materials and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- COVID-19 Clinical Research Studies
- Advanced Nanomaterials in Catalysis
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Nanoparticles: synthesis and applications
- Quantum Dots Synthesis And Properties
- Carbon and Quantum Dots Applications
- CRISPR and Genetic Engineering
- Silymarin and Mushroom Poisoning
- Berberine and alkaloids research
- Dendrimers and Hyperbranched Polymers
Manipal Academy of Higher Education
2020-2025
Shri Vile Parle Kelavani Mandal
2019
Hepatocellular carcinoma (HCC) is recognized as a global health issue accounting for millions of deaths every year. Surgery, liver ablation, and embolization therapy are amongst the conventional methods treatment HCC. Chemotherapy plays major role in HCC therapy, however, owing to its pharmacotherapy limitations, it necessitates development novel therapeutic strategies. In contrast, nanomedicines have shown remarkable prospects solving these complications their high stability, controlled...
MXenes are two-dimensional transition metal carbides, nitrides, and carbonitrides that have become important materials in nanotechnology because of their remarkable mechanical, electrical, thermal characteristics. This review emphasizes how crucial MXene conjugates for several biomedical applications, especially the field cancer. These (2D) nanoconjugates with photothermal, chemotherapeutic, photodynamic activities demonstrated promise highly effective noninvasive anticancer therapy....
Topical drug delivery holds immense significance in dermatological treatments due to its non-invasive nature and direct application the target site. Organogels, a promising class of topical systems, have acquired substantial attention for enhancing efficiency. This review article aims explore advantages organogels, including enhanced solubility, controlled release, improved skin penetration, non-greasy formulations, ease application. The mechanism organogel permeation into is discussed,...
The evolution of genetic exploration tools, from laborious methods like radiationinduced mutations to the transformative CRISPR-Cas9 system, has fundamentally reshaped research and gene editing capabilities. This journey, initiated by foundational techniques such as ZFNs TALENs culminating in groundbreaking work Doudna Charpentier 2012, ushered an era precise DNA alteration profound insights into functions. CRISPR/Cas9 system uses Cas9 enzyme guides RNA (gRNA) precisely target cleave DNA,...
The present investigation emphasizes on synthesis and characterization of thiol functionalized reduced graphene oxide (TrGO) as a novel platform for loading anticancer drug methotrexate (TrGO-MTX), through amide bonding. Thiolation (GO) was achieved by transesterification process. introduction sulfur containing chemical groups the partial reduction GO to TrGO were proven analytical techniques. Thiol content found be 6.98 mM Ellman's method in quantitative manner. Furthermore, antineoplastic...
A key diterpene lactone of Andrographis paniculata, i.e., andrographolide (AG), exhibits a variety physiological properties, including hepatoprotection. The limited solubility, short half-life, and poor bioavailability limits the pharmacotherapeutic potential AG. Therefore, in this study we aimed to formulate optimize AG-loaded nanoliposomes (AGL) using Design Experiment (DOE) approach further modify surface liposomes with mannosylated chitosan enhance its oral bioavailability. Physical,...
Iron-based metal-organic frameworks (MIL (101)) have recently gained attention in materials science for biomedical applications. In the present work, MOF (MIL-101(Fe)) were coated with lactoferrin (Lf) conjugated hyaluronic acid (HA) and investigated its potential delivering 5-fluorouracil (5-FU), along assessing toxicity profile. The synthesised nanoparticles extensively characterised using spectroscopic, X-Ray, thermal electron microscopic techniques. 5-FU was loaded into MOFs,...
The unique physical and chemical properties of monometallic nanoparticles have been comprehensively explored. Analogously, the combination two metals induces alterations in system's electron density, termed as Bimetallic (BMNP's) were found to be more desirable than due improved stability, activity, selectivity, thus altering chemical, optical, electrical properties. In this review, we showcase importance context biomedical applications. article sheds light on utilising BMNP's field...
5-Fluorouracil (5-FU), a BCS class III drug, has low oral bioavailability and is cytotoxic in nature causing severe systemic side effects when administered through the intravenous route. Topical drug delivery could potentially mitigate side-effects. Microemulsions (MEs) would be an apt solution due to enhanced partitioning of skin. However, conventional methods for preparing MEs are inefficient since they not continuous very tedious time-consuming processes hence revealing need development...