A5006203621- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Diet and metabolism studies
- Gut microbiota and health
- Heart Failure Treatment and Management
- Biochemical Analysis and Sensing Techniques
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Congenital Heart Disease Studies
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Pharmaceutical Practices and Patient Outcomes
- Nutrition and Health in Aging
- Adenosine and Purinergic Signaling
- Breastfeeding Practices and Influences
- Sulfur Compounds in Biology
- Cardiovascular Effects of Exercise
- Milk Quality and Mastitis in Dairy Cows
- Neuroscience of respiration and sleep
- Genetic Syndromes and Imprinting
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Urinary Tract Infections Management
- Cardiac Fibrosis and Remodeling
- Obstructive Sleep Apnea Research
Cleveland Clinic
2020-2024
Cleveland Clinic Lerner College of Medicine
2020-2024
Hesco (United States)
2024
Hartford Hospital
2023
Washington State University
2012
University of Wollongong
2010
Abstract Aims Precision microbiome modulation as a novel treatment strategy is rapidly evolving and sought goal. The aim of this study to determine relationships among systemic gut microbial metabolite levels incident cardiovascular disease risks identify pathways possible targets for personalized therapeutic interventions. Methods results Stable isotope dilution mass spectrometry methods quantitatively measure aromatic amino acids their metabolites were used examine sequential subjects...
Heart failure with preserved ejection fraction (HFpEF) is a common but poorly understood form of heart failure, characterized by impaired diastolic function. It highly heterogeneous multiple comorbidities, including obesity and diabetes, making human studies difficult.
Abstract Background and Aims The pathways metabolites that contribute to residual cardiovascular disease risks are unclear. Low-calorie sweeteners widely used sugar substitutes in processed foods with presumed health benefits. Many low-calorie alcohols also produced endogenously, albeit at levels over 1000-fold lower than observed following consumption as a substitute. Methods Untargeted metabolomics studies were performed on overnight fasting plasma samples discovery cohort (n = 1157) of...
Iron deficiency is common in pulmonary hypertension, but its clinical significance and optimal definition remain unclear.
Background: Invasive hemodynamic evaluation through right heart catheterization plays an essential role in the diagnosis, categorization, and risk stratification of patients with pulmonary hypertension. Methods: Subjects enrolled PVDOMICS (Redefining Pulmonary Hypertension Vascular Disease Phenomics) program undergo extensive invasive that includes repeated measurements at rest during several provocative physiological challenges. It is a National Institutes Health/National Heart, Lung, Blood...
Although artificial and non-nutritive sweeteners are widely used generally recognized as safe by the US European Union regulatory agencies, there have been no clinical trials to assess either long-term cardiovascular disease risks or short-term disease-relevant phenotypes. Recent studies report that fasting plasma levels of erythritol, a commonly sweetener, clinically associated with heightened incident enhance thrombosis potential in vitro animal models. Effects dietary erythritol on...
Normative changes in right ventricular (RV) structure and function have not been characterized the context of treatment-associated functional recovery (RV [RVFnRec]). The aim this study is to assess clinical relevance a proposed RVFnRec definition.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. The gut microbiome has been implicated in outcomes for HCC, and microbe-derived products may serve as potential non-invasive indices early HCC detection. This study evaluated differences plasma concentrations microbiota-derived metabolites. Methods: Forty-one patients with 96 healthy controls were enrolled from surgical clinics at Cleveland Clinic 2016 to 2020. Gut circulating metabolites detectable compared...
(Abstracted from Urogynecology 2024;30:50–58 Pelvic organ prolapse can be effectively treated with the nonsurgical use of pessaries. Some minor adverse effects occur this treatment, such as bleeding, vaginal discharge, and pessary extrusion.
ABSTRACT Background Heart failure with preserved ejection fraction (HFpEF) is a significant public health concern limited treatment options. Dysregulated nitric oxide-mediated signaling has been implicated in HFpEF pathophysiology, however, little known about the role of endogenous hydrogen sulfide (H2S). Objectives This study evaluated H2S bioavailability patients and two animal models cardiometabolic assessed impact on severity through alterations production pharmacological...
Abstract Background Cardiovascular disease (CVD) remains the leading cause of death in developed countries. Elevated levels gut-microbe-associated metabolite trimethylamine-N-oxide (TMAO) have been associated with increased risk for CVD mortality many large independent studies. In fact, laboratory corporations such as Labcorp and Quest Diagnostic now offer TMAO diagnostic tests assessment a marker disease-associated dysbiosis, using samples obtained from fasting patients. Although strong...
Background: Recent reports suggest increased myocardial iNOS expression leads to excessive protein s-nitrosylation, contributing the pathophysiology of HFpEF. However, relationship between NO bioavailability, dynamic regulation s-nitrosylation by trans- and de-nitrosylases, HFpEF has not been elucidated. Here, we provide novel insights into delicate interplay bioavailability in Methods: Plasma nitrite, nitrosothiols (RsNO), 3-nitrotyrosine (3-NT) were measured patients controls. Studies WKY...
Abstract Background Normative changes in right ventricular (RV) structure and function have not been characterized the context of treatment-associated functional recovery (RVFnRec). The aim this study is to assess clinical relevance a proposed RVFnRec definition. Methods We evaluated 63 incident patients with PAH by heart catheterization cardiac MRI (CMR) at diagnosis CMR invasive cardiopulmonary exercise (CPET) following treatment (∼11 months). Sex, age, race/ethnicity matched healthy...
Importance Pessary-related adverse effects are common, and treatment options limited. Probiotics may improve pessary-related by altering the vaginal microenvironment. Objective This study aimed to evaluate effect of a probiotic suppository on microenvironment among pessary users. Study Design Women who used pessaries were randomized use versus without use. The intervention was moisturizing gel. assessed using Gram stain Nugent's criteria at baseline 3 months microbiologist blinded group...