A5108029571- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- 3D Printing in Biomedical Research
University of California, Los Angeles
2021-2025
Chordomas are rare tumors of notochordal origin, most commonly arising in the sacrum or skull base. considered insensitive to conventional chemotherapy, and their rarity complicates running timely adequately powered trials identify effective treatments. Therefore, there is a need for discovery novel therapeutic approaches. Patient-derived organoids can accelerate drug development studies predict patient responses therapy. In this proof-of-concept study, we successfully established from seven...
Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder, affecting approximately in 3,500 individuals worldwide. Mutations the NF1 gene impair function of tumor suppressor protein neurofibromin, which plays crucial role regulating cell proliferation and differentiation. Alterations lead to dysregulation RAS signaling pathway uncontrolled proliferation. Approximately 90% patients develop cutaneous neurofibromas (cNFs)—benign skin tumors Although benign, cNFs cause substantial...
Abstract Neurofibromatosis Type I (NF1) is a tumor-predisposing genetic disorder driven by pathogenic variants in the NF1 gene. The development of neurofibromas, including cutaneous neurofibromas (cNFs) and plexiform (pNFs), constitutes major challenge management. Although cNFs do not carry risk malignant transformation, they are associated with significant comorbidities. Furthermore, benign pNFs have evolving into peripheral nerve sheath tumors (MPNSTs), rare type soft tissue sarcoma, ≈15%...
Abstract Pediatric sarcomas are a diverse group of malignancies accounting for ∼15% all childhood solid tumors. Osteosarcomas constitute the most common bone tumor in pediatric patient population. There about 1, 000 new cases diagnosed each year United States, with greatest incidence adolescence and sixth decade life. Overall, 5-year survival rates ∼60% as low ∼20-30% metastatic disease. In primary setting, neoadjuvant MAP chemotherapy including methotrexate, adriamycin (doxorubicin),...
Abstract Sarcomas are a family of rare malignancies composed over 100 distinct histological subtypes. The rarity sarcoma poses significant challenges in conducting clinical trials to identify effective therapies, the point that many rarer subtypes do not have standard-of-care treatment. Even for established regimens, there can be substantial heterogeneity responses. Overall, novel, personalized approaches identifying treatments needed improve patient out-comes. Patient-derived tumor...
Abstract Chordomas are rare tumors of notochordal origin, most commonly arising in the sacrum or skull base. Primary treatment chordoma is surgery, however complete resection not always feasible due to their anatomic location, and recurrence rates remain high. considered insensitive conventional chemotherapy, rarity complicates running timely adequately powered trials identify effective regimens. Therefore, there a need for discovery novel therapeutic approaches. Drug efforts have been...
Abstract Metastatic osteosarcoma is a rare and highly lethal cancer that affects children young adults. The rarity of its heterogeneous genetic composition have resulted in lack curative treatments for recurrent metastatic disease. In this study, we present the functional molecular characterization case pediatric patient with left distal femur pulmonary metastases at presentation. Through longitudinal sampling over course patient’s illness, procured tissue from initial treatment-naïve...