A5046897266- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Autism Spectrum Disorder Research
- Axon Guidance and Neuronal Signaling
- Amino Acid Enzymes and Metabolism
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuropeptides and Animal Physiology
- Genetics and Neurodevelopmental Disorders
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Angiogenesis and VEGF in Cancer
- EEG and Brain-Computer Interfaces
- Pharmacological Receptor Mechanisms and Effects
- Single-cell and spatial transcriptomics
- Transcranial Magnetic Stimulation Studies
- Metabolism and Genetic Disorders
- Tryptophan and brain disorders
- Adipose Tissue and Metabolism
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2024
Fondazione Santa Lucia
2015-2024
University of Rome Tor Vergata
2011-2024
Research Network (United States)
2024
University of Lausanne
2023
University of Calabria
2009-2010
Abstract Multimodal astrocyte–neuron communications govern brain circuitry assembly and function 1 . For example, through rapid glutamate release, astrocytes can control excitability, plasticity synchronous activity 2,3 of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions 4–7 communicate fast focal they should possess an apparatus for Ca 2+ -dependent exocytosis similar neurons 8–10 However, the existence this mechanism has been questioned 11–13...
Abstract Misfolding and aggregation of α-synuclein are specific features Parkinson’s disease other neurodegenerative diseases defined as synucleinopathies. progression has been correlated with the formation extracellular release aggregates, well their spread from neuron to neuron. Therapeutic interventions in initial stages require a clear understanding mechanisms by which disrupts physiological synaptic plastic activity basal ganglia. For this reason, we identified two early time points...
The vascular endothelial growth factors (VEGFs) and their cognate receptors (VEGFRs), besides well-known involvement in physiological angiogenesis/lymphangiogenesis diseases associated to pathological vessel formation, play multifaceted functions the central nervous system (CNS). In addition shaping brain development, by controlling cerebral vasculogenesis regulating neurogenesis as well astrocyte differentiation, VEGFs/VEGFRs axis exerts essential adult both contexts. this article, after...
Abstract Background The accumulation of α‐synuclein (α‐syn) fibrils in intraneuronal inclusions called Lewy bodies and neurites is a pathological signature Parkinson's disease (PD). Although several aspects linked to α‐syn–dependent pathology (concerning its spreading, aggregation, activation inflammatory neurodegenerative processes) have been under intense investigation, less attention has devoted the real impact α‐syn overexpression on structural functional properties substantia nigra pars...
Protocol to evaluate motor coordination of rats by using the rotarod test
Protocol for the preparation of tissue punches SNpc analyses mitochondrial function
Protocol for patch-clamp recordings of SNpc dopamine neurons from midbrain slices
Protocol for the elevated plus maze test performed by rats
Protocol for the open field test performed by rats
Protocol for marble burying test performed by rats
Protocol for rat brain processing to perform parallel histological analysis in one hemisphere and high dimensional flow cytometry the other.
Protocol for analyses of mitochondrial function in SNpc with the Seahorse XFe96
Protocol to evaluate sucrose self-administration in rats
Protocol for immunohistochemistry on rat brain cryosections
Protocols for "Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications sex-biased vulnerability Parkinson’s disease".
Protocol for immunofluorescence on rat brain cryosections
Protocol for stereotaxic virus injection in the substantia nigra pars compacta of rats
Protocol for the preparation of midbrain slices electrophysiology
Protocol for quantifying TH+ fibers in rat dorsal striatum and nucleus accumbens core shell
Protocol for cell counting using StereoInvestigator software.